Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7378 |
BRD9539
|
Histone Methyltransferase | Chromatin/Epigenetic |
BRD9539 是一种组蛋白甲基转移酶G9a 抑制剂,IC50为 6.3 μM,还抑制PRC2活性。 | |||
T1923 |
BRD4770
|
Histone Methyltransferase | Chromatin/Epigenetic |
BRD4770 是组蛋白甲基转移酶G9a 抑制剂,可激活共济失调毛细血管扩张突变途径并诱导细胞衰老。它可抑制H3K9的二甲基和三甲基化,EC50为 5 µM。 | |||
T37450 |
SSK1
|
p38 MAPK | MAPK |
SSK1 是一种选择性杀死衰老细胞的化合物,是一种针对 β-galactosidase 的前体,可减轻机体炎症反应。SSK1 可激活衰老细胞中 p38 MAPK 和 MKK3/MKK6 的磷酸化水平,促使衰老细胞线粒体 DNA 损伤。 | |||
T77767L1 |
GLF16 HCl
|
Others | Others |
GLF16 HCl 是一种荧光团偶联的苏丹黑 B 类似物,可通过通过荧光显微镜和流式细胞术快速检测、分离和实时跟踪衰老细胞。 | |||
T77767L |
GLF16 FA
|
||
GLF16 FA 是一种亲水性荧光 SBB 类似物,可使用流式细胞术和活细胞分选来快速检测衰老细胞。 | |||
T36884 | BM-1244 | ||
BM-1244 is a potent Bcl-xL/Bcl-2 inhibitor with Kis of 134 and 450 nM for Bcl- xL and Bcl-2, respectively. BM-1244 inhibits senescent fibroblasts (SnCs) with an EC50 of 5 nM[1]. | |||
T77767 |
GLF16
|
||
GLF16 是一种亲水性荧光 SBB 类似物,可有效识别衰老。 它可以使用流式细胞术和活细胞分选来快速检测衰老细胞。 GLF16 适用于各种生物材料中单细胞水平的衰老细胞群的体内鉴定、分离和下游表征。 | |||
T76563 |
FOXO4-DRI
|
||
FOXO4-DRI 是一种细胞渗透性肽拮抗剂,可阻断 FOXO4和 p53的相互作用。FOXO4-DRI 是一种抗衰老多肽,可诱导衰老细胞凋亡 (apoptosis)。 | |||
T74867 | UBX1325 | ||
UBX1325 是一种Bcl-xL 抑制剂,可促进衰老细胞的凋亡 (apoptosis)。UBX1325 是一种有效的抗衰老剂,可用于与年龄相关的眼部疾病的研究,如糖尿病性黄斑水肿 (DME)、年龄相关性黄斑变性 (AMD) 和糖尿病性视网膜病变 (DR)。 | |||
T35993 |
Epitalon (acetate)
|
||
Epitalon is a synthetic tetrapeptide with anti-aging properties.1,2,3,4 Dietary administration of epitalon (0.00001% w/w) reduces levels of lipid peroxidation products in aged D. melanogaster tissue homogenates.1 Epitalon (1 μg/animal) delays age-related estrous shutdown and decreases the frequency of bone marrow cell chromosomal aberrations in female mice.2 It decreases spontaneous mammary gland and ovarian tumor development and metastasis in aged female mice.3 Epitalon also stimulates melatoni... | |||
T38043 |
Resolvin E4
|
||
Resolvin E4 (RvE4) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acid by 15-lipoxygenase (15-LO)via15(S)-HpEPE and 15S-hydroxy, 5S-HpEPE intermediatesin vitroand by isolated human M2 macrophages or polymorphonuclear (PMN) neutrophils under normoxic or hypoxic conditions. RvE4 synthesis is enhanced in M2 macrophage and neutrophil co-cultures, indicating transcellular biosynthesis by a potential 15-LO and 5-LO mechanism... |