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Search Results for " sclerostin "

3

抑制剂 & 化合物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T69486	BMD4503-2
	BMD4503-2 is an LRP5/6-sclerostin interaction inhibitor. BMD4503-2 recovers the downregulated activity of the Wnt/β-catenin signaling pathway by competitively binding to the LRP5/6-sclerostin complex.
T81173	Setrusumab BPS 804
	Setrusumab (BPS 804)是一种针对sclerostin的全人源单克隆抗体，具有提升骨骼强度的效能，常用于研究成骨不全症(OI)及癌症治疗。
T78278	Blosozumab
	Blosozumab (LY2541546)为针对人sclerostin (SOST)的单克隆抗体。它能促进骨生成，同时抑制骨吸收，可应用于骨质疏松症相关研究。

化合物

Cat.No: T69486

Cat.No: T81173

Synonym: BPS 804

Cat.No: T78278

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01633	SOST Protein, Rat, Recombinant (His) sclerostin	Rat	HEK293 Cells
	SOST Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23 kDa and the accession number is A6HJF6.
TMPY-00925	SOST Protein, Human, Recombinant (His) VBCH,sclerostin,DAND6,CDD,SOST1	Human	HEK293 Cells
	SOST Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.5 kDa and the accession number is Q9BQB4-1.
TMPJ-01294	SOST Protein, Mouse, Recombinant (His) Sost,Sclerostin	Mouse	HEK293 Cells
	Sclerostin (SOST) is a member of the cerberus/DAN family, a group of secreted glycoproteins characterized by a cysteine-knot motif. Cerberus/DAN family members are putative BMP antagonists, and include Dan, Cerberus, Gremlin, PRDC, and Caronte. While the overall sequence identity between members of the family is low, they have conserved spacing of six cysteine residues. Cerberus and Dan have an additional cysteine residue used for dimerization; however, SOST does not and is secreted as a monomer...
TMPY-05113	SOST Protein, Human, Recombinant (His), Biotinylated VBCH,SOST1,DAND6,sclerostin,CDD	Human	HEK293 Cells
	SOST Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.5 kDa and the accession number is Q9BQB4-1.
TMPK-01293	SOST Protein, Cynomolgus, Recombinant (His) VBCH,SOST1,sclerostin,DAND6,SOST,CDD,VBCHsclerosteo...	Cynomolgus	HEK293 Cells
	SOST, also known as sclerostin, is a member of the cerberus/DAN family, a group of secreted glycoproteins characterized by a cysteine-knot motif. SOST is negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. SOST Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 22.58 kDa and the accession number is XP_005584428.2.
TMPK-00103	SOST Protein, Human, Recombinant (His & Avi), Biotinylated VBCH,DAND6,VBCHsclerosteosis,sclerostin,SOST1,CDD,S...	Human	HEK293 Cells
	SOST, also known as sclerostin, is a member of the cerberus/DAN family, a group of secreted glycoproteins characterized by a cysteine-knot motif. SOST is negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. SOST Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 24.2 kDa and the accession number is Q9BQB4-1.
TMPK-00102	SOST Protein, Human, Recombinant (His & Avi) VBCHsclerosteosis,SOST1,sclerostin,SOST,CDD,DAND6,V...	Human	HEK293 Cells
	SOST, also known as sclerostin, is a member of the cerberus/DAN family, a group of secreted glycoproteins characterized by a cysteine-knot motif. SOST is negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. SOST Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 24.2 kDa and the accession number is Q9BQB4-1.
TMPK-00740	LRP-5 Protein, Human, Recombinant (mFc) LRP7,EVR1,LR3VBCH2,HBM,LRP5,EVR4,VBCH2,OPS,BMND1OPTA1,LR3,OP...	Human	HEK293 Cells
	A role for low-density lipoprotein-related receptor 5 (LRP5) in human bone was first established by the identification of genetic alterations that led to dramatic changes in bone mass. Shortly thereafter, mutations that altered the function of the sclerostin (SOST) gene were also associated with altered human bone mass. Subsequent studies of LRP5 and sclerostin have provided important insights into the mechanisms by which these proteins regulate skeletal homeostasis. LRP-5 Protein, Human, Recomb...
TMPK-00739	LRP-5 Protein, Human, Recombinant (hFc) EVR1,BMND1,BMND1OPTA1,LRP5,LRP7,OPPG,EVR4,OPTA1,OPS,HBM,VBCH...	Human	HEK293 Cells
	A role for low-density lipoprotein-related receptor 5 (LRP5) in human bone was first established by the identification of genetic alterations that led to dramatic changes in bone mass. Shortly thereafter, mutations that altered the function of the sclerostin (SOST) gene were also associated with altered human bone mass. Subsequent studies of LRP5 and sclerostin have provided important insights into the mechanisms by which these proteins regulate skeletal homeostasis. LRP-5 Protein, Human, Recomb...

重组蛋白

SOST Protein, Rat, Recombinant (His)

Cat.No: TMPY-01633

Species: Rat

Expression System: HEK293 Cells

SOST Protein, Human, Recombinant (His)

Cat.No: TMPY-00925

Species: Human

Expression System: HEK293 Cells

SOST Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01294

Species: Mouse

Expression System: HEK293 Cells

SOST Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-05113

Species: Human

Expression System: HEK293 Cells

SOST Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01293

Species: Cynomolgus

Expression System: HEK293 Cells

SOST Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00103

Species: Human

Expression System: HEK293 Cells

SOST Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00102

Species: Human

Expression System: HEK293 Cells

LRP-5 Protein, Human, Recombinant (mFc)

Cat.No: TMPK-00740

Species: Human

Expression System: HEK293 Cells

LRP-5 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00739

Species: Human

Expression System: HEK293 Cells

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