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Search Results for " pyrrolizidine "

13

抑制剂 & 化合物

22

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T125765	1,2-Epoxy-1-hydroxymethylpyrrolizidine
	1,2-Epoxy-1-hydroxymethylpyrrolizidine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125765。
T32751	Ligularidine Crotaverrine acetate
	Ligularidine is a pyrrolizidine alkaloid.
T31365	Dehydrolasiocarpine
	Dehydrolasiocarpine is a pyrrolizidine alkaloid.
T32251	Jaconine hydrochloride NSC30624,Jaconine HCl,NSC-30624,NSC 30624
	Jaconine hydrochloride is a Pyrrolizidine alkaloid.
T34391	Rosmarinine
	Rosmarinine is a non-toxic pyrrolizidine alkaloid.
T32215	Isoline Ruwenine
	Isoline is a pyrrolizidine alkaloid isolated from the traditional Chinese medicine Ligularia duciformis.
T31367	Dehydroretrorsine Retrorsine pyrrole
	Dehydroretrorsine is a pyrrolizidine alkaloid metabolite.
T34305	Retusamine
	Retusamine is a pyrrolizidine alkaloid.
T32763	Lindelofine
	Lindelofine is a pyrrolizidine alkaloid.
T30970	Clivorine J1.344.443I,Clivorine (neutral)
	Clivorine is an otonecine pyrrolizidine alkaloid from the genus Ligularia.
T40688	Fulvine
	Fulvine, a pyrrolizidine alkaloid extracted from Crotalaria fulva seeds, exhibits hepatotoxic properties and can be employed for inducing hypertensive pulmonary vascular disease in vivo.
T40706	Heliotrine N-oxide
	Heliotrine N-oxide is the pyrrolizidine alkaloid (PA) N-oxide counterpart of Heliotrine. It induces the generation of pyrrolic DNA adducts, potentially initiating PA-induced liver tumors in vivo.
T37843	Australine (hydrochloride)
	Australine is a pyrrolizidine alkaloid originally isolated fromC. australethat has enzyme inhibitory activities.1,2,3It is an inhibitor of glucoamylase (IC50= 5.8 μM) that also inhibits glucosidase I, sucrase, maltase, andA. nigerα-glucosidase (IC50s = 20, 28, 35, and 28 μM, respectively).2,3Australine is selective for these enzymes over glucosidase II, α- and β-mannosidase, and α- and β-galactosidase up to 500 μM, β-glucosidase, with only 5% inhibition at 66 μM, as well as isomaltase and trehal...

化合物

1,2-Epoxy-1-hydroxymethylpyrrolizidine

Cat.No: T125765

Cat.No: T32751

Synonym: Crotaverrine acetate

Dehydrolasiocarpine

Cat.No: T31365

Jaconine hydrochloride

Cat.No: T32251

Synonym: NSC30624,Jaconine HCl,NSC-30624,NSC 30624

Cat.No: T34391

Cat.No: T32215

Synonym: Ruwenine

Dehydroretrorsine

Cat.No: T31367

Synonym: Retrorsine pyrrole

Cat.No: T34305

Cat.No: T32763

Cat.No: T30970

Synonym: J1.344.443I,Clivorine (neutral)

Cat.No: T40688

Heliotrine N-oxide

Cat.No: T40706

Australine (hydrochloride)

Cat.No: T37843

Cat. No.	Product Name	Target	Signaling Pathways
T3S2340	Usaramine (15E)-Retrorsine,Mucronatine,光萼野百合碱,NISTC15503874	Others; Antibacterial	Microbiology/Virology; Others
	Usaramine (Mucronatine) 是从 Crolatalaria pallida 种子中分离得到的一种吡咯里嗪类生物碱。它对 Lactuca sativa var 具有植物毒性。
TN1078	Seneciphylline 千里光菲灵碱,千里光非灵	P450; GST	Metabolism; oxidation-reduction
	Seneciphylline 是一种有毒的吡咯烷核生物碱，存在于千里光植物中。它显著增加了环氧水合酶和谷胱甘肽-S-转移酶的特性，但导致细胞色素 P-450 和相关单加氧酶特性的抑制。
TN2147	Retrorsine	P450; OCT	Membrane transporter/Ion channel; Metabolism
	Retrorsine 特异性地抑制肝细胞增殖，并在肝损伤后唤起小肝细胞样祖细胞。逆转录酶可用于肝细胞损伤的研究。
TQ0192	Senecionine Aureine,Senecionan-11,16-dione, 12-hydroxy-,千里光宁,Senecionin	Others	Others
	Senecionine (Senecionin) 是一种吡咯里西啶生物碱，从Senecio vulgaris 中分离得到，它对动物和人类有毒性。
T2803	Monocrotaline 野百合碱,Crotaline	TGF-beta/Smad	Stem Cells
	Monocrotaline (Crotaline) 是一种吡咯里西啶生物碱，从猪屎豆植物的种子中提取得到，可诱导啮齿动物产生肺动脉高血压。
TN3835	Desacetyldoronine	Others	Others
	Desacetyldoronine is a hepatotoxic pyrrolizidine alkaloid.
TL0011	Adonifoline	Others	Others
	Adonifoline is a hepatotoxic pyrrolizidine alkaloid.
T20635	Senkirkin Renardin
	Senkirkin is a pyrrolizidine alkaloid with hepatotoxicity.
T40856	7-Acetylintermedine
	7-Acetylintermedine is a hepatotoxic botanical pyrrolizidine alkaloid.
T34749	Supinine AI3 51772,AI3-51772,AI351772
	Supinine is a pyrrolizidine alkaloid.
T25724	Ligularine
	Ligularine is a hepatotoxic otonecine-type pyrrolizidine alkaloid isolated from Ligularia hodgsonii, a Chinese traditional antitussive medicine.
T32198	Retrorsine N-oxide Isatidine
	Isatidine is a pyrrolizidine alkaoid.
T81273	Rinderine N-oxide
	Rinderine N-oxide，一种来源于R. graeca的吡咯里西啶生物碱。
T40519	Indicine N-oxide (+)-Indicine N-oxide,Indicine N-oxide,NSC132319
	Indicine N-oxide (NSC 132319), a pyrrolizidine alkaloid, serves as an antitumor agent in pediatric cancer and solid tumors research.
T40501	Erucifoline
	Erucifoline, a pyrrolizidine alkaloid, is present in the aerial components of Senecio aquaticus.
T38429	(+)-Intermedine
	(+)-Intermedine, a pyrrolizidine alkaloid (PA), shows remarkable cytotoxic activity against neural progenitor cells (NPCs).
T40484	Jacobine N-oxide
	Jacobine N-oxide is a pyrrolizidine alkaloid compound found in thrips-resistant Senecio hybrids.
T20524	Lasiocarpine 7-Angelyleuropine,(-)-Lasiocarpine,Europine 7-angelate,AI3-51770
	Lasiocarpine is a pyrrolizidine alkaloid, it has acute cytotoxicity in human and hepatic cell lines.
T40512	Echimidine N-oxide
	Echimidine N-oxide, a pyrrolizidine alkaloid, exhibits significant inhibitory activity against acetylcholinesterase (AChE) with an IC50 value of 0.347 mM.
T75671	Senecionine acetate
	Senecionine acetate (O-Acetylsenecionine)为吡咯烷核生物碱，通过使游离巯基失活，抑制线粒体及其区域内Ca2+的螯合。
TN2204	Seneciphylline N-oxide
	Seneciphylline N-oxide 是从 Emilia sonchifolia 中提取得到的吡咯里西啶生物碱，Senecionine N-oxide 的脱氢产物。
TN2203	Senecionine N-oxide Senecionine oxide
	Senecionine n-oxide 是千里光寻常型根部培养物中吡咯烷核生物碱生物合成的主要产物，Senecionine N-oxide (Senecionine oxide) 具有抗肿瘤活性，但可诱导肝窦阻塞综合征。Senecionine n-oxide可作为 N-氧化物螯合示踪剂。

天然产物

Cat.No: T3S2340

Synonym: (15E)-Retrorsine,Mucronatine,光萼野百合碱,NISTC15503874

Target: Others, Antibacterial

Cat.No: TN1078

Synonym: 千里光菲灵碱,千里光非灵

Target: P450, GST

Cat.No: TN2147

Target: P450, OCT

Cat.No: TQ0192

Synonym: Aureine,Senecionan-11,16-dione, 12-hydroxy-,千里光宁,Senecionin

Target: Others

Cat.No: T2803

Synonym: 野百合碱,Crotaline

Target: TGF-beta/Smad

Desacetyldoronine

Cat.No: TN3835

Target: Others

Cat.No: TL0011

Target: Others

Cat.No: T20635

Synonym: Renardin

7-Acetylintermedine

Cat.No: T40856

Cat.No: T34749

Synonym: AI3 51772,AI3-51772,AI351772

Cat.No: T25724

Retrorsine N-oxide

Cat.No: T32198

Synonym: Isatidine

Rinderine N-oxide

Cat.No: T81273

Indicine N-oxide

Cat.No: T40519

Synonym: (+)-Indicine N-oxide,Indicine N-oxide,NSC132319

Cat.No: T40501

(+)-Intermedine

Cat.No: T38429

Jacobine N-oxide

Cat.No: T40484

Cat.No: T20524

Synonym: 7-Angelyleuropine,(-)-Lasiocarpine,Europine 7-angelate,AI3-51770

Echimidine N-oxide

Cat.No: T40512

Senecionine acetate

Cat.No: T75671

Seneciphylline N-oxide

Cat.No: TN2204

Senecionine N-oxide

Cat.No: TN2203

Synonym: Senecionine oxide

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