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Search Results for " purines "

13

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T21588	Olomoucine	ERK; CDK	Cell Cycle/Checkpoint; MAPK
	Olomoucine 是 Cdk2/cyclin A、Cdc2/CyclinB、CDK2/CyclinE、CDK5/p35 和 ERK1/p44 MAP 激酶的 ATP 竞争性抑制剂，IC50 分别为 7、7、7、3 和 25 µM。 Olomoucine 调节细胞周期并表现出抗黑色素肿瘤活性。
T22409	Proguanil 氯胍,chloroguanide,chlorguanide	Others	Others
	Proguanil, a prophylactic antimalarial drug, inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of pyrimidines and purines, which are essential for DNA synthesis and cell multiplication.
TNU1134	7-benzyl-3-methylxanthine
	7-benzyl-3-methylxanthine belongs to Heterocyclic Compounds - Purines.
TNU1262	1H-Imidazo[4,5-d]pyridazin-7-amine
	1H-Imidazo[4,5-d]pyridazin-7-amine belongs to Heterocyclic Compounds - Purines; Intermediates and Building Blocks - Nucleoside bases.
TNU0909	1,9-Dihydro-9-methyl-6H-purin-6-one
	1,9-Dihydro-9-methyl-6H-purin-6-one belongs to Heterocyclic Compounds - Purines.
TNU1133	1,7-Dibenzyl-3-methylxanthine
	1,7-Dibenzyl-3-methylxanthine belongs to Heterocyclic Compounds - Purines.
TNU0907	6-Chloro-9-methyl-9H-purine
	Heterocyclic Compounds - Purines; Intermediates and Building Blocks - Electrophiles
TNU0908	9-Methyladenine
	Heterocyclic Compounds - Purines; Intermediates and Building Blocks - Nucleophiles
TNU0900	2-Amino-6-ethoxypurine
	Heterocyclic Compounds –Purines; Intermediates and Building Blocks - Nucleoside bases
TNU1104	6-Chloro-2-(trifluoromethyl)-9H-purine
	Heterocyclic Compounds - Purines; Intermediates and Building Blocks - Nucleoside bases; Multi-functional; Scaffolds and Templates
TNU0611	4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine
	Heterocyclic compound –purines, intermediate and building block; Used for modified nucleosides and nucleic acids
T35413	(6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride)
	(6R,S)-5,6,7,8-Tetrahydrofolic acid (THFA), the reduced form of folic acid, serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism. Its metabolites participate in the synthesis of thymidine for incorporation into DNA or the synthesis of purines, as well as in the formation of methionine, which can be converted to the ubiquitous methyl donor, S-adenosylmethionine . THFA has also been used to study the activation of metabolite-binding ribos...
T63240	Lometrexol disodium
	Lometrexol (DDATHF) disodium 是人丝氨酸羟甲基转移酶 1/2 (hSHMT1/2) 的有效抑制剂，也是抗嘌呤类抗叶酸 (antifolate) 药，能够降低甘氨酰胺核糖核苷酸甲酰基转移酶 (GARFT) 的活性，但不引起可检测水平的 DNA 链断裂。Lometrexol disodium 对嘌呤从头合成具有抑制作用，可造成异常的细胞增殖，凋亡 (apoptosis) 和细胞周期停滞，表现出抗癌效果。

化合物

Cat.No: T21588

Target: ERK, CDK

Cat.No: T22409

Synonym: 氯胍,chloroguanide,chlorguanide

Target: Others

7-benzyl-3-methylxanthine

Cat.No: TNU1134

1H-Imidazo[4,5-d]pyridazin-7-amine

Cat.No: TNU1262

1,9-Dihydro-9-methyl-6H-purin-6-one

Cat.No: TNU0909

1,7-Dibenzyl-3-methylxanthine

Cat.No: TNU1133

6-Chloro-9-methyl-9H-purine

Cat.No: TNU0907

9-Methyladenine

Cat.No: TNU0908

2-Amino-6-ethoxypurine

Cat.No: TNU0900

6-Chloro-2-(trifluoromethyl)-9H-purine

Cat.No: TNU1104

4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine

Cat.No: TNU0611

(6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride)

Cat.No: T35413

Lometrexol disodium

Cat.No: T63240

Cat. No.	Product Name	Target	Signaling Pathways
T4746	Purine 7H-Imidazo(4,5-d)pyrimidine,嘌呤	Others; Endogenous Metabolite	Metabolism; Others
	Purine (7H-Imidazo(4,5-d)pyrimidine) 是内源性代谢产物的一种。

天然产物

Cat.No: T4746

Synonym: 7H-Imidazo(4,5-d)pyrimidine,嘌呤

Target: Others, Endogenous Metabolite

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