17
3
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4449 |
LB100
LB-100,LB 100 |
Phosphatase | Metabolism |
LB100 (LB-100) 是一种水溶性蛋白磷酸酶 2A(PP2A) 抑制剂。 | |||
T2068 |
(Rac)-LB-100
|
Phosphatase | Metabolism |
LB-100 是一种新型蛋白磷酸酶 2A (PP2A) 抑制剂,可使恶性脑膜瘤细胞对放射治疗效果敏感。 | |||
T2747 |
Endothall
|
Others | Others |
Endothall 是一种有效的蛋白磷酸酶 2A (PP2A) 抑制剂,对 PP2A 和 PP1 具有抑制作用, IC50 分别为 90 nM 和 5 µM。Endothall 具有抗癌活性,可用于癌症化疗,可用作除草剂。 | |||
T65086 |
Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride
|
Apoptosis; Phosphatase | Apoptosis; Metabolism |
Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride 可能会引起致敏作用。 Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride 促进 HepG2 (IC50= 62μM)和SK-Hep1(IC50= 151μM)细胞凋亡且对蛋白磷酸酶2A具有抑制作用。 | |||
T15082 |
DDAO
|
Others | Others |
DDAO 是有潜在用途的近红外红色荧光探针,其激发波长 (600-650 nm) 和长发射波长 (λem = 656 nm)可以调节。它可用于不同酶活性的检测,如 β-半乳糖苷酶,羧酸酯酶 2,硫酸酯酶,蛋白质磷酸酶 2A,人白蛋白和酯酶。 | |||
T35528L |
TD52 dihydrochloride
TD52 dihydrochloride(1798328-24-1 Free base),TD52 2HCl |
Others | Others |
TD52 dihydrochloride (TD52 2HCl), a derivative of Erlotinib, is a potent and orally active inhibitor of protein phosphatase 2A (CIP2A). It exhibits strong anti-cancer properties by regulating the CIP2A/PP2A/p-Akt signaling pathway, resulting in the induction of apoptosis in triple-negative breast cancer (TNBC) cells. Mechanistically, TD52 dihydrochloride disrupts the binding of Elk1 to the CIP2A promoter, effectively reducing CIP2A levels. Notably, TD52 dihydrochloride demonstrates powerful anti... | |||
T14859 |
Calyculin A
(-)-Calyculin A |
Others | Others |
Calyculin A is a potent and cell-permeable inhibitor of protein phosphatase 1 (PP1; IC50s: 2 nM). It also is a protein phosphatase 2A (PP2A) inhibitor (IC50s: 0.5-1 nM). | |||
T39239 |
TRC-766
|
||
TRC-766, a negative control of RTC-5 (TRC-382), is a compound that exhibits protein phosphatase 2A (PP2A) binding properties while lacking phosphatase activation capabilities. | |||
T10060L |
DT-061
|
Phosphatase | Metabolism |
DT-061 is an orally bioavailable protein phosphatase 2A (PP2A) activator. It could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis. | |||
T20153 |
FTY720-C2
FTY 720 C 2,FTY-720-C-2 |
||
FTY720-C2 is an FTY720 analog. It acts as an effective stimulator of the activity of the protein phosphatase 2A. | |||
T83530 | LB-100 | ||
(Rac)-LB-100为LB-100的外消旋体,系一种蛋白磷酸酶2A(PP2A)抑制剂。 | |||
T31882 |
FTY720-Mitoxy
FTY 720 Mitoxy,FTY-720-Mitoxy |
||
FTY720-Mitoxy is an FTY720 analog that can be uesd as a novel stimulator of the activity of the protein phosphatase 2A (PP2A), targeting mitochondria. | |||
T35777 |
Nodularin
|
||
The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea. Nodularin is a hepatotoxic monocylic pentapeptide produced by the N. spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026 nM, respectively. PP2B is inhibited to a lesser extent with an IC50 of 1.8 μM. No apparent inhibitory eff... | |||
T35806 |
N-Stearoylsphingosine
C(18:0)/C(18:1),Cer(d18:1/18:0),C18 Ceramide (d18:1/18:0),C18 Ceramide |
Phosphatase | Metabolism |
N-Stearoylsphingosine (Cer(d18:1/18:0)) 是一种广泛存在真核生物体内的酰胺类化合物,通过干扰PP2A与PP2A抑制剂2的结合来增强蛋白质磷酸酶2A(PP2A)活性,导致Akt去磷酸化。N-Stearoylsphingosine 可用于研究前列腺癌。 | |||
T82938 | ATUX-1215 | ||
ATUX-1215是一种蛋白磷酸酶 2A (PP2A)的激活剂,能够在BLM治疗的动物模型中降低ERK、p38、JNK和Akt的磷酸化及IL-12p70、GM-CSF与IL1α的分泌,从而有助于减缓肺纤维化的发展。 | |||
T35613 |
Cytostatin (sodium salt)
|
||
Cytostatin (sodium salt) is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 μg/ml, respectively) and B16 cells metastatic activity in mice. It induces apoptosis of FS3 mouse fibrosarcoma cells (IC50 = 3.1 μg/ml). Cytostatin (sodium salt) potently and selectively inhibits protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), while having no effect agai... | |||
T83938 |
TAT-PDHPS1
|
||
TAT-PDHPS1是一种针对Yes-associated protein (YAP) 信号的肽抑制剂。它由内源性肽PDHPS1和能穿透细胞的肽序列TAT组成。PDHPS1与蛋白磷酸酶2磷酸酶激活因子(PTPA)结合, 激活蛋白磷酸酶2A (PP2A)。该激活促进YAP的磷酸化和抑制YAP靶向基因的表达。TAT-PDHPS1能够抑制体外卵巢癌细胞的增殖和小鼠皮下异种移植肿瘤模型中的卵巢肿瘤生长。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1305 |
Ethoxysanguinarine
乙氧基血根碱,6-Ethoxydihydrosanguinarine |
Apoptosis; AChR | Apoptosis; Neuroscience |
Ethoxysanguinarine (6-Ethoxydihydrosanguinarine) 是存在于龙葵中的一种苯并菲啶生物碱天然产物,通过抑制蛋白磷酸酶 2A,可抑制结直肠癌细胞活力,诱导细胞凋亡。 | |||
T70725 | Motuporin | ||
Motuporin is an inhibitor of type-1 and type-2A protein phosphatase catalytic subunits (PP-1c and PP-2Ac). | |||
T37055 |
Cytostatin
|
||
Cytostatin is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 μg/ml, respectively) and B16 cells metastatic activity in mice. It induces apoptosis of FS3 mouse fibrosarcoma cells (IC50 = 3.1 μg/ml). Cytostatin potently and selectively inhibits protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), while having no effect against PP1, PP2B, or PP5. |