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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T36043	17(R)-Protectin D1 17(R)-Protectin D1
	17(R)-Protectin D1 is an aspirin-triggered epimer of the specialized pro-resolving mediator protectin D1 .1It decreases leukotriene B4-induced transendothelial migration of human polymorphonuclear (PMN) neutrophils when used at concentrations ranging from 0.1 to 10 nM. 17(R)-Protectin D1 (0.01-10 ng) reduces the recruitment of neutrophils in a mouse model of TNF-α-induced peritonitis. 1.Serhan, C.N., Fredman, G., Yang, R., et al.Novel proresolving aspirin-triggered DHA pathwayChem. Biol.18(18)97...
T37379	Protectin D1 Neuroprotectin D1,NPD1	Akt; PI3K	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Protectin D1 (Neuroprotectin D1) 是神经细胞产生的神经保护素，是一种潜在的心脏保护剂。Protectin D1 通过调节 PI3K/AKT 信号通路缓解心肌缺血/再灌注损伤，抑制咪喹莫特诱导的银屑病样皮肤炎症。
T12684	Radioprotectin-1 5-chloro-2-[4-(1,3-dioxobenzo[de]isoquinolin-2-yl)butylsulfamoyl]benzoic acid	LPA Receptor	GPCR/G Protein
	Radioprotectin-1 是特异性的 LPA2 激动剂，对小鼠 LPA2 GPCR 的 EC50 为 25 nM，具有辐射保护和辐射缓解作用。
T25148	beta-Neuroprotectin Ala-asp-leu-ile-ala-tyr-leu-NH2
	beta-Neuroprotectin is a (3H)TCP binding inhibitor and provides protection against NMDA mediated neuronal cell death at low concentration.
T37300	PCTR1 PCTR1
	Protectin conjugates in tissue regeneration 1 (PCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is then converted to PCTR1 by glutathione S-transferase. PCTR1 levels increase during resolution of acute microbial-induced peritonitis in mice. PCTR1 (30 ng, i.p.) administration 12 hours post-infection increases macrophage numbers and activity and shortens the resolution phase of inflammation by 57%. It als...
T37488	10(S),17(S)-DiHDHA
	Protectin D1 (also known as neuroprotectin D1 when produced in neuronal tissues) is a DHA-derived dihydroxy fatty acid that exhibits potent protective and anti-inflammatory activities. 10(S),17(S)-DiHDHA is a DHA metabolite, also referred to as protectin DX (PDX). It is produced by an apparent double lipoxygenase (LO)-mediated reaction in murine peritonitis exudates, in suspensions of human leukocytes, or by soybean 15-LO incubated with DHA. It differs from protectin D1 with respect to the stere...
T37301	PCTR2
	Protein conjugates in tissue regeneration 2 (PCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to PCTR1 by glutathione S-transferase and to PCTR2 via γ-glutamyl transpeptidase. PCTR2 is found in resolving mouse exudate and in both M1 and M2 macrophages differentiated from isolated human monocytes.
T36999	7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
	Novel oxylipins, referred to as docosanoids, have been derived from C22polyunsaturated fatty acids 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic acid (7(S),17(S)-hydroxy DPA) is a DPA-derived analog of the 17(S)-dihydroxy series of docosanoids known as protectins. Protectin D1, a DHA-derived dihydroxy fatty acid, exhibits potent anti-inflammatory activities.1,2,3Potentially, 7(S),17(S)-hydroxy DPA demonstrates similar properties; however, its biological activity has yet to b...
T37302	PCTR3
	Protein conjugates in tissue regeneration 3 (PCTR3) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to PCTR1 by glutathione S-transferase and to PCTR2 and PCTR3 via peptidases. PCTR3 is found in infected mouse spleens and resolving exudate as well as isolated human spleen and septic plasma. It is also found in both M1 and M2 macrophages differentiated from isolated human monocytes.
T37166	RCTR1
	Resolvin conjugate in tissue regeneration 1 (RCTR1) is a specialized pro-resolving mediator (SPM) biosynthesized from docosahexaenoic acid by isolated human macrophages and apoptotic polymorphonuclear (PMN) neutrophils.1It has been found in human spleen and bone marrow.2RCTR1 is produced via lipoxygenase-mediated oxidation of DHA to 7(S)-8-epoxy-17(S)-HDHA, which is conjugated to glutathione.1,2,3RCTR1 (10 nM) increases phagocytosis ofE. colior apoptotic neutrophils in isolated human monocyte-de...

化合物

17(R)-Protectin D1

Cat.No: T36043

Synonym: 17(R)-Protectin D1

Target:

Protectin D1

Cat.No: T37379

Synonym: Neuroprotectin D1,NPD1

Target: Akt, PI3K

Radioprotectin-1

Cat.No: T12684

Synonym: 5-chloro-2-[4-(1,3-dioxobenzo[de]isoquinolin-2-yl)butylsulfamoyl]benzoic acid

Target: LPA Receptor

beta-Neuroprotectin

Cat.No: T25148

Synonym: Ala-asp-leu-ile-ala-tyr-leu-NH2

7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02503	CD59a Protein, Mouse, Recombinant (hFc) AA987121,CD59a antigen,Cd59,protectin,RP24-297H17.1	Mouse	HEK293 Cells
	CD59a Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 35.4 kDa and the accession number is A2BI31.
TMPY-02266	CD59a Protein, Mouse, Recombinant (His) CD59a antigen,Cd59,protectin,RP24-297H17.1,AA987121	Mouse	HEK293 Cells
	CD59a Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 9.7 kDa and the accession number is A2BI31.

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CD59a Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-02503

Species: Mouse

Expression System: HEK293 Cells

CD59a Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02266

Species: Mouse

Expression System: HEK293 Cells

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