Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TQ0084 |
lumateperone Tosylate
ITI-007,Lumateperone甲苯磺酸盐 |
Dopamine Receptor; 5-HT Receptor | GPCR/G Protein; Neuroscience |
lumateperone Tosylate (ITI-007) 是5-HT 2A 受体拮抗剂,Ki 为 0.54 nM,突触前 D2受体的部分激动剂和突触后 D2受体的拮抗剂,Ki 为 32 nM。 | |||
T21069 |
Lumateperone
ITI 722,ITI722,ITI-007,卢美哌隆,ITI007 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Lumateperone (ITI 722) 是一种 5HT2A 受体拮抗剂和多巴胺受体磷蛋白调节剂 (DPPM)。 | |||
T68190 | Carmoxirole (free base) | ||
Carmoxirole (free base) is a dopamine D2 receptor agonist with limited central activity that modulates sympathetic activation and subsequently reduces pre-load and afterload in animals. It was shown, that carmoxirole induced beneficial effects on hemodynamic and neurohumoral parameters in heart failure. In addition, experimental evidence showed that carmoxirole lowered blood pressure in various models of hypertension mainly or exclusively through inhibition of noradrenaline release from sympathe... |