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Search Results for " positive control "

10

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T21859	ARM1	Aminopeptidase; Epoxide Hydrolase	Metabolism
	ARM1 是氨基肽酶和环氧化物水解酶抑制剂，IC50分别为为7.61 µM 和12.4 µM。
T41319	D-Saccharic acid 1,4-lactone hydrate	Others	Others
	D-Saccharic acid 1,4-lactone hydrate 是β-葡萄糖醛酸酶的有效抑制剂（IC50=48.4 μM），可用作标准药物。D-Saccharic acid 1,4-lactone hydrate 显示出抗癌、解毒和抗氧化的活性性。
T14571	Bifenazate	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Bifenazate 是 GABA 受体的正向变构调节剂。 Bifenazate 是一种杀螨剂，可在 25 ppm 的浓度下控制 100% 的螨虫。
T40296	MCA17-1 MCA17-1
	MCA17-1 exhibits superior bioactivity compared to the positive control, obeticholic acid (OCA), in the treatment of liver fibrosis.
T82398	Firefly Luciferase circRNA
	Firefly Luciferase circRNA 是一种从Photinus pyralis（萤火虫）分离的荧光素酶蛋白，适用于作为环状RNA转染的阳性对照，用于监测和优化转染效率。
T71097	DC-120
	DC-120 is an ATP competitive AKT kinase inhibitor that suppressed proliferation and induced apoptosis in liver cancer cells both in vitro and in vivo. DC120 blocked the phosphorylation of downstream molecules in the AKT signal pathway in dose- and time-dependent manners both in vitro and in vivo. DC120 inhibits AKT activity in vitro with an EC(50) of 153 nM. DC120 at 20 mg/kg/day inhibited the CNE2 xenograft tumor growth with a treated group/control group ratio of 38.1%, accompanied by increas...
T82497	eGFP circRNA
	eGFP circRNA，能够编码由Aequorea victoria水母分离得到的绿色荧光蛋白。作为哺乳动物细胞培养中的常规直接检测报告蛋白，其在509 nm波长下发出鲜明的绿光。eGFP circRNA作为环状RNA转染的首选阳性对照，对于监测及提升转染效率具有重要意义。
T35422	5'-pApA (sodium salt)
	5'-pApA is a linearized form of cyclic di-AMP, a bacterial second messenger that activates the host innate immune system through stimulator of interferon genes (STING).1,2,3,4It is a metabolite of cyclic di-AMP formedviahydrolysis by various phosphodiesterases (PDEs).55'-pApA is intended for use as a negative control for cyclic di-AMP signaling. 1.Burdette, D.L., Monroe, K.M., Sotelo-Troha, K., et al.STING is a direct innate immune sensor of cyclic-di-GMPNature478(7370)515-518(2011) 2.Parvatiyar...
T67442	CGP-53716
	The growth factors, platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) play major roles in enhanced smooth muscle cells growth in rodent blood vessels after vascular injury. Tyrosine kinase inhibition has been shown to be effective in blocking tyrosine phosphorylation at the PDGF and bFGF receptors in cultured fibroblast and vascular smooth muscle cells which in turn inhibits their proliferation[1]. CGP 53716 is a specific PDGFR tyrosine kinase inhibitor on SMC (smoo...
T36629	Givinostat
	Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF3056. At 25, 50, and 100 nM, Givinostat reduced IL-1β secretion more than 70%. Givinostat (ITF-2357) suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18. IL-6 secretion decreases to 50% at 50 nM Givinostat, but at 1...

化合物

Cat.No: T21859

Target: Aminopeptidase, Epoxide Hydrolase

D-Saccharic acid 1,4-lactone hydrate

Cat.No: T41319

Target: Others

Cat.No: T14571

Target: GABA Receptor

Cat.No: T40296

Synonym: MCA17-1

Firefly Luciferase circRNA

Cat.No: T82398

Cat.No: T71097

Cat.No: T82497

5'-pApA (sodium salt)

Cat.No: T35422

Cat.No: T67442

Cat.No: T36629

Cat. No.	Product Name	Target	Signaling Pathways
TN3056	4-O-Galloylbergenin	Others	Others
	4-O-Galloylbergenin shows significant 2,2-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging activity with EC50 7.8 uM, it shows more antioxidant activity than the positive control vitamin C (EC50 = 28.3 uM).
TN5154	Torilolone	Others	Others
	Torilin and torilolone show hepatoprotective effects on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells,the EC50 values are 20.6 +/- 1.86 and 3.6 +/- 0.1 microM, respectively; and silybin as a positive control shows an EC50 value of 69.0
TN1606	(-)-Epiafzelechin (-)-表阿夫儿茶精,表阿夫儿茶精	COX	Immunology/Inflammation; Neuroscience
	(-)-Epiafzelechin exhibits significant anti-inflammatory activity on carrageenin-induced mouse paw edema, it exhibits a dose-dependent inhibition on the COX activity with an IC50 value of 15 microM, it exhibits about 3-fold weaker inhibitory potency on th

天然产物

4-O-Galloylbergenin

Cat.No: TN3056

Target: Others

Cat.No: TN5154

Target: Others

(-)-Epiafzelechin

Cat.No: TN1606

Synonym: (-)-表阿夫儿茶精,表阿夫儿茶精

Target: COX

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