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Search Results for " pneumoniae "

70

抑制剂 & 化合物

14

天然产物

2

同位素

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Cat. No.	Product Name	Target	Signaling Pathways
T79088	Chlamydia pneumoniae-IN-1	Antibacterial	Microbiology/Virology
	Chlamydia pneumoniae-IN-1 是一种对衣原体有抑制作用的苯并咪唑类化合物，在低浓度下即可对肺炎衣原体产生抑制作用。Chlamydia pneumoniae-IN-1 具有抗菌活性，对CV-6菌株的 MIC 为12.6 μM，可用于研究肺部感染。
T40417	Ethylhydrocupreine hydrochloride Optochin hydrochloride,乙氢去甲奎宁盐酸盐；奥普托欣盐酸盐	Antibacterial; Parasite	Microbiology/Virology
	Ethylhydrocupreine hydrochloride (Optochin hydrochloride) 是奎宁的一种衍生物，具有抗菌作用，可抑制肺炎链球菌的活性。Ethylhydrocupreine hydrochloride 具有抗疟活性，对 Plasmodium falciparum 的IC50为 25.75 nM。Ethylhydrocupreine hydrochloride 是Gallus gallus2 受体 (ggTas2r1，ggTas2r2和ggTas2r7) 激动剂。
T9318	TP0586532	Others	Others
	TP0586532 是有效的non-hydroxamate LpxC 抑制剂 (IC50=0.101 μM)。TP0586532具有低心血管风险的特点，对肺炎克雷伯菌有效，包括耐药菌株。
T11876	LpxH-IN-AZ1	Antibacterial	Microbiology/Virology
	LpxH-IN-AZ1 是一种有效的 UDP-2,3-二酰基葡糖胺焦磷酸水解酶LpxH 抑制剂，也是磺酰基哌嗪化合物。LpxH-IN-AZ1 具有抗菌活性，对肺炎克雷伯菌具有抑制作用，IC50 为 0.36 μM。
T60092	CHEMBL1276927 N-[3-(1H-benzimidazol-2-yl)phenyl]-3-methylbenzamide,N-(3-(1H-benzo[d]imidazol-2-yl)phenyl)-3-methylbenzamide,N-[3-(1H-苯并[d]咪唑-2-基)苯基]-3-甲基苯甲酰胺	Antibacterial; Parasite	Microbiology/Virology
	CHEMBL1276927 (N-(3-(1H-benzo[d]imidazol-2-yl)phenyl)-3-methylbenzamide) 对肺炎衣原体和多诺瓦尼利什曼原虫具有抗菌和抗寄生虫活性。
T77551	6'-hydroxydihydrocinchonidine	Antibiotic; Drug Metabolite	Metabolism; Microbiology/Virology
	6'-hydroxydihydrocinchonidine 是奎宁的代谢产物,具有抗菌和抗肿瘤活性，对布氏锥虫和肺炎链球菌有抑制作用。
T0331L	Moxifloxacin Avelox,Moxeza,莫西沙星	Others; Antibacterial; Antibiotic	Microbiology/Virology; Others
	Moxifloxacin (Avelox) 是一种8-甲氧基喹诺酮类口服有效抗菌药物，用于急性细菌性鼻窦炎，慢性支气管炎的急性细菌性加重和感染性肺炎的研究。
T2331	Solithromycin 索利霉素,OP-1068,CEM-101	Antibacterial; Antibiotic	Microbiology/Virology
	Solithromycin (OP-1068) 是口服可生物利用的抗菌剂，抑制肺炎链球菌、葡萄球菌、金黄色葡萄球菌和流感嗜血杆菌的细胞活力、蛋白质合成和生长速率， IC50 值分别为 7.5 ng/mL、40 ng/mL 和 125 ng/mL。它可与核糖体的大 50S 亚基结合抑制蛋白质生物合成。
T4063	Delafloxacin ABT492,WQ-3034,德拉沙星,RX-3341	Antibacterial; Antibiotic	Microbiology/Virology
	Delafloxacin (WQ-3034) 是一种广谱氟喹诺酮类抗生素，抑制耐药性的金黄色葡萄球菌，肺炎链球菌和肺炎克雷伯菌。
T38137	3,5-Dimethylbenzaldehyde	Endogenous Metabolite; Antifungal	Metabolism; Microbiology/Virology
	3,5-Dimethylbenzaldehyde 具有广谱的抗菌活性，对枯草芽孢杆菌、白假丝酵母菌、大肠杆菌、铜绿假单胞菌、金黄色葡萄杆菌和肺炎链球菌具有抑制作用。
T11265	Faropenem daloxate 法罗培南酯,Faropenem medoxil	Antibacterial; Antibiotic	Microbiology/Virology
	Faropenem daloxate (Faropenem medoxil) 是β-内酰胺类口服抗生素。
T41275	PF-04753299	Others	Others
	PF-04753299 是一种有效的、选择性的LpxC 抑制剂。PF-04753299 对淋球菌分离株具有杀菌作用，对大肠杆菌、铜绿假单胞菌和肺炎菌株的抑制的MIC90值分别为 2 μg/ml、4 μg/ml 和 16 μg/ml。PF-04753299 用于革兰氏阴性菌感染的研究。
T35449	α-(difluoromethyl)-DL-Arginine DFMA,RMI 71897,α-(difluoromethyl)-DL-Arginine	Others	Others
	α-(difluoromethyl)-DL-Arginine (RMI 71897) 是一种酶激活的、不可逆的大肠杆菌(Ki = 800 μM)、铜绿假单胞菌和肺炎克雷伯菌精氨酸脱羧酶抑制剂。在0.01 mM 时，它已被证明可以防止渗透胁迫诱导的燕麦叶片细胞精氨酸脱羧酶活性和腐胺合成的增加。当α-(difluoromethyl)-DL-Arginine 与多种多胺类似物联用时，能在10 mM 的最低浓度下抑制克氏锥虫在哺乳动物宿主细胞中的生长，并在T 细胞受体α缺陷小鼠模型中阻止小锥虫的生长。
T28209	NSC65847	Others	Others
	NSC65847 is a novel dual inhibitor of viral and Streptococcus pneumoniae neuraminidase.
T62773	OX11	Others	Others
	OX11 是一种 S. pneumoniae、P. aeruginosa 和 E. coli 细菌的选择性抑制剂。
T70835	（4R，9S)-AG 205
	AG-205 is a potent inhibitor of FabK, the enoyl-ACP reductase in Streptococcus pneumoniae.
T5189L	Omadacycline mesylate PTK 0796,PTK-0796,PTK0796	Others	Others
	Omadacycline is an aminomethylcycline antibiotic. Omadacycline demonstrated net cidal activity in relation to the initial burden against four strains of Streptococcus pneumoniae.
T40088	TP0586352	Others	Others
	TP0586352 is a potent inhibitor of LpxC, exhibiting efficacy against carbapenem-resistant strains of Klebsiella pneumoniae without inducing cardiovascular risks.
T72330	Antibacterial agent 19	Others	Others
	Antibacterial agent 19 是一种有效的抗菌剂。Antibacterial agent 19 对K. pneumoniae，(M-R)S. aureus 和 (M-R,V-R)S. aureus 具有抗菌活性, 其 MIC 值为 0.022, 0.022 和 0.045 mg/mL。
T80385	K11
	K11是一种具有针对MDR/XDR K. pneumoniae活性的抗菌肽（MIC: 8-512 μg/mL），能够抑制该细菌的生物膜的形成。它还可以与多种抗生素（如Chloramphenicol、Meropenem、Rifampicin等）产生协同效应，增强对耐药K. pneumoniae的抗性。此外，K11显示出良好的高温稳定性和在宽pH范围内的稳定性。
T37721	Dihydronovobiocin	Others	Others
	Dihydronovobiocin is a coumarin antibiotic and derivative of novobiocin .1It is active against the bacteriaS. aureus,S. haemolyticus,D. pneumoniae,S. typhosa,K. pneumoniae, andP. multocida(MICs = 0.6, 2, 0.6, 10, 10, and 3 μg/ml, respectively).2Dihydronovobiocin inhibits DNA gyrase subunit B with an IC50value of 64.5 nM.3 1.Berger, J., and Batcho, A.D.Coumarin - glycoside antibioticsJ. Chromatogr. Lib.15101-158(1978) 2.Hoeksema, H.Dihydronovobiocin and derivatives thereof3,175,9441-9(1965) 3.Gev...
T38559	Competence-Stimulating Peptide-2 (CSP-2)
	Competence-Stimulating Peptide-2 (CSP-2) is a quorum sensing signal peptide synthesized by Streptococcus pneumoniae. ComD2, a compatible receptor of CSP-2, exhibits an EC 50 value of 50.7 nM.
T63695	Antibacterial agent 90
	Antibacterial agent 90 (6n) 是抗细菌 (antibacterial) 的 pleuromutilin 衍生物，对 Gram-positive pathogens (GPPs) 和Mycoplasma pneumoniae 表现出抗菌活性。
T75516	Seconeolitsine	Others	Others
	Seconeolitsine，一种抗生素，是一种靶向拓扑异构酶 I(TopA)的抑制剂。Seconeolitsine 也是一种新的抗菌剂，可以抑制 S. pneumoniae 的生长。Seconeolitsine 具有抑制 TopA 的活性，其 b>IC50值为 17 μM。Seconeolitsine 可用于对其他抗生素耐药的肺炎链球菌感染的研究。
T80411	Bactenecin 5
	Bactenecin 5是一种具有抗菌活性的牛抗菌肽，能够针对Escherichia coli、Salmonella typhimurium和Klebsiella pneumoniae. T发挥作用，其最小抑菌浓度（MIC）介于12-25 μg/mL之间。
T39758	ARX-1796 ARX-1796,AV-006	Others	Others
	ARX-1796 (AV-006), an Avibactam prodrug, is an orally bioavailable β-lactamase inhibitor. Avibactam has a spectrum of inhibition of class A and C β-lactamases, including ESBLs, AmpC and Klebsiella pneumoniae carbapenemase (KPC) enzymes.
T30826	Cgp 31523A Cgp-31523A,Cgp31523A
	CGP 31523a is a new type of aminothiazolyl cephalosporin, which can inhibit Escherichia coli, Klebsiella pneumoniae, Pseudomonas mirabilis, Clostridium diving, Klebsiella acidogenes, Pseudomonas Stuart, Salmonella, and Shigella.
T25767	Lysobactin Katanosin A, 7-L-isoleucine-,Katanosin B
	Lysobactin, also known as katanosin B, is an effective antibiotic with in vivo efficacy against Staphylococcus aureus and Streptococcus pneumoniae. It was previously shown to inhibit peptidoglycan (PG) biosynthesis.
T63512	LpxC-IN-10	Others	Others
	LpxC-IN-10 是一种选择性的 LpxC 抑制剂，对 E. coli 和 K. pneumoniae 的 MIC 值为0.5 μg/mL，能够用于研究细菌感染。
T68438	APO-6619
	APO-6619 is an iron chelator which was shown to inhibit growth of the following bacterial strains: Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli. APO-6619 may be useful as a non-traditional treatment of bacterial infections.
T60470	KPC-2-IN-2	Others	Others
	KPC-2-IN-2 (Compound 6c) 是一种有效的 Klebsiella pneumoniae carbapenemase 碳青霉烯酶 (KPC-2) 抑制剂，Ki 值为0.038 μM。KPC-2-IN-2 可以增强表达 KPC-2 的大肠杆菌中头孢噻肟的活性。
T81737	MurF-IN-1	Others	Others
	MurF-IN-1 (Compound 7)，一种MurF抑制剂，展现了针对S. pneumoniae MurF的显著抑制活性，其pIC50值为5.19。
T38021	Obafluorin	Others	Others
	Obafluorin is a β-lactone antibiotic that has been found in P. fluorescens.1 It is active against S. aureus, S. faecalis, K. pneumoniae, and P. vulgaris (MIC = 125 μg/ml for all). \|1. Pu, Y., Lowe, C., Sailer, M., et al. Synthesis, stability, and antimicrobial activity of (+)-obafluorin and related β-lactone antibiotics. J. Org. Chem. 59(13), 3642-3655 (1994).
T30481	BK 218 BK218,BK-218
	BK 218 is a novel cephalosporin, which is active against streptococcus pneumoniae, Haemophilus influenza, and Moraxella catarrase, but has a higher MIC against penicillin-resistant strains. Bk-218 has dual administration routes and the activity spectrum m
T36032	Desotamide	Others	Others
	Desotamide is a cyclic hexapeptide antibiotic originally isolated from Streptomyces. It is active against S. aureus, S. pneumoniae, and methicillin-resistant S. epidermidis (MRSE; MICs = 16, 12.5, and 32 μg/ml, respectively).
T38334	Corynecin III
	Corynecin III is a chloramphenicol-like antibiotic originally isolated from Corynebacterium. It inhibits the growth of Gram-positive and Gram-negative bacteria, including S. faecalis, S. aureus, B. subtilis, E. coli, P. aeruginosa, P. vulgaris, S. sonnei, S. typhosa, and K. pneumoniae (MICs = 2.6-83 μg/ml).
T72532	Ethylhydrocupreine Optochin
	Ethylhydrocupreine (Optochin) 是一种具有抗菌作用的奎宁衍生物，具有抗肺炎链球菌 (S. pneumoniae) 的活性。Ethylhydrocupreine 还具有抗Plasmodiumfalciparum 的抗疟活性，IC50为 25.75 nM。Ethylhydrocupreine 是一种Gallus gallus2 受体 (ggTas2r1，ggTas2r2和ggTas2r7) 激动剂。
T37888	Desacetylcephapirin sodium
	Desacetyl cefapirin is an active metabolite of the cephalosporin antibiotic cefapirin .1 Desacetyl cefapirin is active against E. coli, K. pneumoniae, P. mirabilis, and S. aureus with MIC values of 120, 24, 34, and 0.42 μg/ml, respectively.References1. Jones, R.N., and Packer, R.R. Cefotaxime, cephalothin, and cephapirin: Antimicrobial activity and synergy studies of cephalosporins with significant in vivo desacetyl metabolite concentrations. Diagn. Microbiol. Infect. Dis. 2(1), 65-68 (1984). De...
T80372	P1
	P1是一种具有抗革兰氏阳性菌与抗革兰氏阴性菌能力的广谱抗菌肽，有效针对B. anthracis、耐碳青霉烯类细菌A. baumannii和K. pneumoniae。
T36028	Desacetylcefotaxime (potassium salt)	Others	Others
	Desacetylcefotaxime is an active metabolite of the cephalosporin antibiotic cefotaxime .1It is active against 60 clinical isolates derived from patients with meningitis, includingH. influenzae,S. pneumoniae,S. agalactiae, andN. meningitidis(MIC90s = 0.008-0.12 μg/ml). 1.Jones, R.N.Cefotaxime and desacetylcefotaxime antimicrobial interactions. The clinical relevance of enhanced activity: A reviewDiagn. Microbiol. Infect. Dis.22(1-2)19-33(1995)
T39296	DS86760016	Others	Others
	DS86760016 is a highly effective inhibitor of leucyl-tRNA synthetase (LeuRS), demonstrating potent activity against multidrug-resistant (MDR) Gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Notably, DS86760016 effectively inhibits LeuRS enzymes derived from Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii, exhibiting IC50 values of 0.38 μM, 0.62 μM, and 0.16 μM, respectively.
T38333	Corynecin I	Others	Others
	Corynecin I is a chloramphenicol-like antibiotic originally isolated from Corynebacterium. It is active against Gram-positive and Gram-negative bacteria with MIC values of 5.2-83 μg/ml for S. sonnei, P. vulgaris, K. pneumoniae, and S. aureus among others.
T39175	CSP1
	CSP1 is a highly potent and selective agonist of the ComD1 receptor, exhibiting an IC50 value of 10.3 nM. It represents a major variant of competence-stimulating peptide (CSP) and plays a crucial role in regulating the genetic transformation of S. pneumoniae through modulation of quorum sensing (QS). Additionally, CSP1 possesses antibacterial activity, further enhancing its potential as an effective antibacterial agent.
T16749	Rifalazil 利福拉齐,KRM-1648,ABI-1648	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Rifalazil is a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polymerase. Rifalazil is an antibiotic, exhibits high potency against mycobacteria, gram-positive bacteria, Helicobacter pylori, C. pneumoniae and C. trachomatis (MIC: 0.00025 to 0.0025 μg/ml).
T60797	β-Lactamase-IN-7	Others	Others
	β-Lactamase-IN-7 (compound 14) 能够有效抑制肺炎克雷伯菌，它是 VIM 型金属 β 内酰胺酶的有效抑制剂，对VIM-1和VIM-4的Ki 值分别为 1.26 μM 和 0.54 μM。
T38259	Phenelfamycin E
	Phenelfamycin E is an antibiotic originally isolated from Streptomyces. It is active against β-hemolytic Streptoccus, S. pneumoniae, C. difficile, C. perfringens, and P. magnus128 μg/ml). Phenelfamycin E (4-64 mg/kg) increases survival in a mouse model of lethal S. pyogenes infection in a dose-dependent manner. Dietary administration of phenelfamycin E increases body weight in chickens.
T84433	Doripenem hydrate

T78673	Antibacterial agent 135
	Antibacterialagent 135（示例7）是一种针对多种细菌具有抑制作用的有效抗菌剂，包括铜绿假单胞菌、鲍曼不动杆菌、大肠杆菌和肺炎克雷伯菌，其最小抑菌浓度（MIC）大于64 μg/mL。
T38608	Brilacidin tetrahydrochloride PMX 30063 tetrahydrochloride
	Brilacidin tetrahydrochloride (PMX 30063 tetrahydrochloride) is a defensin mimetic antibiotic compound, exhibiting potent anti-infective antimicrobial activity against a range of bacteria. It demonstrates MIC90 values of 1 μg/mL and 8 μg/mL against the Gram-positive bacteria Streptococcus pneumoniae and Streptococcus viridans, respectively. Additionally, it has a MIC90 value of 8 μg/mL for the Gram-negative bacteria Haemophilus influenzae and a MIC90 value of 4 μg/mL for Pseudomonas aeruginosa.
T28311	PD 116152 PD116,152,PD 116,152,PD116152,PD-116,152,PD-116152
	PD 116152 is a highly substituted phenazine with antitumor activity isolated from the culture broth of a Streptomyces sp. The antitumor activity versus murine P388 leukemia is T/C 149. PD 116152 is selectively active versus the bacterium Streptococcus pne

化合物

Chlamydia pneumoniae-IN-1

Cat.No: T79088

Target: Antibacterial

Ethylhydrocupreine hydrochloride

Cat.No: T40417

Synonym: Optochin hydrochloride,乙氢去甲奎宁盐酸盐；奥普托欣盐酸盐

Target: Antibacterial, Parasite

Cat.No: T9318

Target: Others

Cat.No: T11876

Target: Antibacterial

Cat.No: T60092

Synonym: N-[3-(1H-benzimidazol-2-yl)phenyl]-3-methylbenzamide,N-(3-(1H-benzo[d]imidazol-2-yl)phenyl)-3-methylbenzamide,N-[3-(1H-苯并[d]咪唑-2-基)苯基]-3-甲基苯甲酰胺

Target: Antibacterial, Parasite

6'-hydroxydihydrocinchonidine

Cat.No: T77551

Target: Antibiotic, Drug Metabolite

Cat.No: T0331L

Synonym: Avelox,Moxeza,莫西沙星

Target: Others, Antibacterial, Antibiotic

Cat.No: T2331

Synonym: 索利霉素,OP-1068,CEM-101

Target: Antibacterial, Antibiotic

Cat.No: T4063

Synonym: ABT492,WQ-3034,德拉沙星,RX-3341

Target: Antibacterial, Antibiotic

3,5-Dimethylbenzaldehyde

Cat.No: T38137

Target: Endogenous Metabolite, Antifungal

Faropenem daloxate

Cat.No: T11265

Synonym: 法罗培南酯,Faropenem medoxil

Target: Antibacterial, Antibiotic

Cat.No: T41275

Target: Others

α-(difluoromethyl)-DL-Arginine

Cat.No: T35449

Synonym: DFMA,RMI 71897,α-(difluoromethyl)-DL-Arginine

Target: Others

Cat.No: T28209

Target: Others

Cat.No: T62773

Target: Others

（4R，9S)-AG 205

Cat.No: T70835

Omadacycline mesylate

Cat.No: T5189L

Synonym: PTK 0796,PTK-0796,PTK0796

Target: Others

Cat.No: T40088

Target: Others

Antibacterial agent 19

Cat.No: T72330

Target: Others

Cat.No: T80385

Dihydronovobiocin

Cat.No: T37721

Target: Others

Competence-Stimulating Peptide-2 (CSP-2)

Cat.No: T38559

Antibacterial agent 90

Cat.No: T63695

Cat.No: T75516

Target: Others

Cat.No: T80411

Cat.No: T39758

Synonym: ARX-1796,AV-006

Target: Others

Cat.No: T30826

Synonym: Cgp-31523A,Cgp31523A

Cat.No: T25767

Synonym: Katanosin A, 7-L-isoleucine-,Katanosin B

Cat.No: T63512

Target: Others

Cat.No: T68438

Cat.No: T60470

Target: Others

Cat.No: T81737

Target: Others

Cat.No: T38021

Target: Others

Cat.No: T30481

Synonym: BK218,BK-218

Cat.No: T36032

Target: Others

Cat.No: T38334

Ethylhydrocupreine

Cat.No: T72532

Synonym: Optochin

Desacetylcephapirin sodium

Cat.No: T37888

Cat.No: T80372

Desacetylcefotaxime (potassium salt)

Cat.No: T36028

Target: Others

Cat.No: T39296

Target: Others

Cat.No: T38333

Target: Others

Cat.No: T39175

Cat.No: T16749

Synonym: 利福拉齐,KRM-1648,ABI-1648

Target: DNA/RNA Synthesis

β-Lactamase-IN-7

Cat.No: T60797

Target: Others

Phenelfamycin E

Cat.No: T38259

Doripenem hydrate

Cat.No: T84433

Antibacterial agent 135

Cat.No: T78673

Brilacidin tetrahydrochloride

Cat.No: T38608

Synonym: PMX 30063 tetrahydrochloride

Cat.No: T28311

Synonym: PD116,152,PD 116,152,PD116152,PD-116,152,PD-116152

Cat. No.	Product Name	Target	Signaling Pathways
T7999	7-Hydroxyflavanone	Anti-infection	Microbiology/Virology
	7-Hydroxyflavanone 对肺炎链球菌临床分离株显示出抗菌活性。
TN1203	2,3,8-Tri-O-methylellagic acid 2,3,8-三邻甲基鞣花酸	Antifection	Microbiology/Virology
	2,3,8-tri-O-Methyl ellagic acid has antimicrobial activity agaist Vibro cholera, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacillus cereus, Escherichia coli.
T69058	OM173-αA
	OM173-αA is a quinone bacterial metabolite that inhibits the growth of the bacteria M. gallisepticum, M. pneumoniae, and S. aureus. OM173-αA also inhibits the growth of the plant pathogenic fungus P. oryzae and several species of Trichophyton.
TN4634	Neocyclomorusin	Antifection	Microbiology/Virology
	Neocyclomorusin displays minimal inhibitory concentration (MIC) value of 4 ug/mL against Klebsiella pneumoniae ATCC11296, Enterobacter cloacae BM47.
T83920	4-Trehalosamine
	4-Trehalosamine是一种在Streptomyces中发现的微生物代谢产物，具有抗生素活性。在杯碟法测试中，当浓度为0.5、1和2 mg/ml时，对E. coli、K. pneumoniae和B. subtilis展现出活性。
TN4594	Murraol	Antifection	Microbiology/Virology
	Murraol shows the significant proliferative activities on osteoblast-like UMR106 cells lines at the concentration of 1 × 10-10 mol/L. It and auraptenol show 63 ug/mL MIC value against Klebsiella pneumoniae ATCC 4352 and Bacillus subtilis ATCC 9372.
T38019	Nybomycin
	Nybomycin is a fungal metabolite originally isolated from Streptomyces sp. A717 and has antibacterial activity. It is active against B. subtilis, B. cereus, B. mycoides, M. smegmatis, and K. pneumoniae (MICs = 0.025, 2, 0.8, 0.2, and 0.003 μg/ml, respectively). Nybomycin is also active against M. tuberculosis and M. bovis (MICs = 4.5 and 1 μg/ml, respectively).
T38086	Neohydroxyaspergillic Acid	Others	Others
	Neohydroxyaspergillic acid is a fungal metabolite produced by A. sclerotiorum that has antibiotic and antifungal activities. It inhibits the growth of P. aeruginosa, M. smegmatis, S. aureus, E. coli, K. pneumoniae, B. mycoides, and B. subtilis bacteria (MICs = 125-500 μg/ml). Neohydroxyaspergillic acid also inhibits the growth of G. convolute, S. consortiale, P. blakesleeanus, C. globosum, and T. mentagrophytes (MICs = 175-700 μg/ml) but not A. niger, P. notatum, M. verrucaria, or S. cerevisiae ...
TN7324	(±)-ε-Viniferin
	(±)-ε-Viniferin，ε-Viniferin的外消旋体，展现P450抑制性抗氧化、保肝及抗菌特性。该化合物对革兰氏阳性菌肺炎链球菌显示出抗菌和抗生物膜活性，最小抑制浓度（MIC）为20 μM。
T83903	Polymyxin B2 sulfate	Others	Others
	Polymyxin B2是一种抗生素，并且是从B. polymyxa分离出的阳离子脂肽抗生素polymyxin B的主要成分。该化合物对P. aeruginosa、A. baumannii、K. pneumoniae和E. cloacae菌株具有活性（MICs分别为1-2、0.5-1、0.25-0.5和0.25-1 µg/ml）。在体内实验中，以4 mg/kg剂量的Polymyxin B2能显著降低P. aeruginosa血液感染小鼠模型中的血液集落形成单位(CFUs)数量。
T35409	(+)-δ-Cadinene	Apoptosis; Antibacterial	Apoptosis; Microbiology/Virology
	(+)-δ-Cadinene 是一种从G. hirsutum 中发现的倍半萜，具有抗菌、杀虫、抗癌和抗增殖活性。它对肺炎双球菌的MIC 值为31.25 μg/ml，对 A. stephensi、A. aegypti 和 C. quinquefasciatust 三龄幼虫的LC50s 值分别8.23、9. 2和3。(+)-δ-Cadinene（10、50 和 100 μM）可诱导 OVCAR-3 人类卵巢癌细胞凋亡并抑制其增殖。
T36329	Terpendole I
	Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 145 μM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 μg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 μg/ml for all) or the fungus C. albicans (MIC = 200 μg/ml).1,2 It is cytotoxic to HeLa cells with an IC50 value of 52.6 μM.3 \|1. Tomoda, H., Tabata, N., Yang, D.-J., et al. Ter...
T83693	Magainin 2 TFA MG2	Others	Others
	Magainin 2是一种从非洲爪蟾（X. laevis）皮肤中分离出的阳离子肽，具有宿主防御和抗菌活性。该化合物对细菌E. coli、K. pneumoniae、S. epidermidis、S. aureus及真菌C. albicans表现出活性（MICs分别为5、10、10、50和80 µg/ml）。Magainin 2（20 µM）能降低猕猴桃花粉的萌发率和平均管长。在被单纯疱疹病毒1型（HSV-1）或2型（HSV-2）感染的Vero细胞中，它可减少病毒复制（EC50s分别为22.16和19.8 µM），同时不影响细胞活性，其50%细胞毒性浓度值（CC50）大于100 µM。
T35779	Oosporein
	Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectively.3Oosporin induces lethality in day-old cockerels (LD50= 6.12 mg/kg).4It inhibits Na+/K+-, Ca2+-, and Mg2+-ATPase activities by 27, 52, and 100%, respectively, in equine erythrocyte ghosts when used at a concentration of 200 μg/ml.2Oosporein inhibits herpes simplex 1 (HSV-1), ...

天然产物

7-Hydroxyflavanone

Cat.No: T7999

Target: Anti-infection

2,3,8-Tri-O-methylellagic acid

Cat.No: TN1203

Synonym: 2,3,8-三邻甲基鞣花酸

Target: Antifection

Cat.No: T69058

Neocyclomorusin

Cat.No: TN4634

Target: Antifection

4-Trehalosamine

Cat.No: T83920

Cat.No: TN4594

Target: Antifection

Cat.No: T38019

Neohydroxyaspergillic Acid

Cat.No: T38086

Target: Others

(±)-ε-Viniferin

Cat.No: TN7324

Polymyxin B2 sulfate

Cat.No: T83903

Target: Others

(+)-δ-Cadinene

Cat.No: T35409

Target: Apoptosis, Antibacterial

Cat.No: T36329

Cat.No: T83693

Synonym: MG2

Target: Others

Cat.No: T35779

Cat. No.	Product Name	Target	Signaling Pathways
T37250	Cefazolin-13C2,15N Cefazolin-13C2,15N
	Cefazolin-13C2,15N is intended for use as an internal standard for the quantification of cefazolin by GC- or LC-MS. Cefazolin is a broad-spectrum cephalosporin antibiotic that is active in vitro against various Gram-positive and Gram-negative bacteria (MICs = 0.2-12.5 μg/ml). It also inhibits the growth of clinical isolates of S. aureus, E. coli, P. mirabilis, and K. pneumoniae (MICs = 0.1-25 μg/ml). In vivo, cefazolin protects against S. aureus, E. coli, and P. mirabilis infection in mice (ED50...
T36021	Flumequine-13C3 Flumequine-13C3
	Flumequine-13C3is intended for use as an internal standard for the quantification of flumequine by GC- or LC-MS. Flumequine is a fluoroquinolone antibiotic.1It is active againstS. aureus, S. pyogenes, B. subtilis, E. coli, P. aeruginosa, S. faecalis, andK. pneumoniae(MICs = 1-100 μg/ml). Flumequine is also active against field isolates of B. hyodysenteriae (MICs = 6.25-200 μg/ml).2It inhibits DNA gyrase, disrupting supercoiling of bacterial DNA to block transcription and replication.3In vivo, fl...

同位素

Cefazolin-13C2,15N

Cat.No: T37250

Synonym: Cefazolin-13C2,15N

Flumequine-13C3

Cat.No: T36021

Synonym: Flumequine-13C3

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