Cat. No. | Product Name | Target | Signaling Pathways |
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T36012 |
p38α inhibitor 2
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p38α inhibitor 2 is a highly potent and selective p38α MAPK inhibitor, with a pIC50 of 9.6. p38α inhibitor 2 inhibits the hERG ion channel (IC50=27 μM) and shows a promising selectivity profile when tested in a panel of 51 other protein kinases (<30% inhibition at 10 μM concentration) and a panel of 141 other biological targets[1]. [1]. Raubo P, et al. The discovery and evaluation of 3-amino-2(1H)-pyrazinones as a novel series of selective p38α MAP kinase inhibitors [published online ahead of pr... | |||
T79145 |
CK1-IN-2
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Casein Kinase | Metabolism; Stem Cells |
CK1-IN-2 (compound Nr.4) 作为CK1抑制剂展现出高效性,其对CK1a、CK1d、CK1e、p38a的IC50值依次为123、19.8、26.8、74.3 nM。 |