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Search Results for " p28 "

8

抑制剂 & 化合物

7

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T83680	Azurin (50-77) (P. aeruginosa) TFA Azurin p28,p28
	Azurin (50-77)是一种含铜细菌蛋白azurin的肽段，存在于P. aeruginosa中，具有细胞周期停滞、抑制癌细胞增殖和调节血管生成活性。作为VEGFR2的抑制剂（IC20约为10.7 µM），Azurin (50-77)（20 µM）能在MCF-7乳腺癌细胞中诱导G2/M期的细胞周期停滞。在50 µM的浓度下，减少MCF-7和ZR-75-1乳腺癌细胞的增殖。Azurin (50-77)以25 µM的浓度减少VEGF-A诱导的毛细管管腔形成（IC50 = 12 µM），降低人脐静脉内皮细胞（HUVECs）中与细胞膜相关的F-actin、焦点粘附激酶（FAK）和paxillin的水平，并增加胞外的血小板内皮细胞粘附分子-1（PECAM-1）的水平。在体内，Azurin (50-77)（每日10 mg/kg）在MCF-7小鼠异种移植模型中减少肿瘤体积。
T80523	Azurin p28 peptide
	Azurin p28 peptide是一种具有肿瘤穿透能力和抗肿瘤活性的肽。它通过与p53结合形成p28:p53复合物，从而降低p53在蛋白酶体中的降解，进而诱导细胞凋亡(apoptosis)或使细胞周期停滞。此外，Azurin p28 peptide通过抑制VEGFR-2、FAK和Akt的磷酸化表现出抗血管生成效果，抑制p53阳性肿瘤的生长。
T74794	USP28-IN-4	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	USP28-IN-4 是一种高效的 USP28 抑制剂，对 USP28 的 IC50 值为 0.04 μM。USP28-IN-4 具有抗癌活性，抑制 USP2、USP7、USP8、USP9x、UCHL3和UCHL5。USP28-IN-4 对人结直肠癌和肺鳞癌细胞具有细胞毒性，通过泛素-蛋白酶体系统对c-Myc的细胞水平进行剂量依赖性下调。
T74793	USP28-IN-3	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	USP28-IN-3是一种高选择性 USP28 抑制剂，对USP28的IC50 值为 0.1 μM。USP28-IN-3 具有抗癌活性，抑制 USP2、USP7、USP8、USP9x、UCHL3和UCHL5。USP28-IN-3 对人结直肠癌和肺鳞癌细胞具有细胞毒性，通过泛素-蛋白酶体系统对c-Myc的细胞水平进行剂量依赖性下调。
T83550	(Asp28)-Glucagon (1-29) (human, rat, porcine)
	'(Asp28)-Glucagon (1-29) (human, rat, porcine)' 为胰高血糖素的一种改良型结构，在第28位氨基酸残基上天冬氨酸（Asp）替换原有残基，显著提高了该化合物在生理pH条件下的溶解性，且保持了与天然胰高血糖素相同的生物活性。
T74792	USP28-IN-2
	USP28-IN-2是一种高选择性的USP28抑制剂(IC50=0.3 μM)，能够特异性作用于USP2、USP7、USP8、USP9x、UCHL3 和 UCHL5。在体外实验中，USP28-IN-2对癌细胞表现出细胞毒性，作用机制为通过泛素-蛋白酶体途径降低c-Myc蛋白水平，并能减少Ankyrase-1/2的表达。此外，USP28-IN-2能增强结直肠癌细胞对药物瑞戈非尼的敏感性。
T76587	(Asp28)-Exenatide
	(Asp28)-Exenatide 是艾塞那肽的降解产物。(Asp28)-Exenatide 可用作GLP-1R 激动剂。
T79731	MLKL-IN-6	Necroptosis	Apoptosis
	MLKL-IN-6（compound P28）是一种针对Mixed Lineage Kinase domain-like（MLKL）的混合谱系激酶抑制剂，具有抗纤维化的潜力。它能够抑制MLKL的磷酸化和寡聚化，从而抑制细胞坏死、免疫细胞死亡，并减少粘附因子的表达。MLKL-IN-6展现出低细胞毒性，并可抑制肝星状细胞的激活，从而降低肝纤维化标志物的水平。

化合物

Azurin (50-77) (P. aeruginosa) TFA

Cat.No: T83680

Synonym: Azurin p28,p28

Azurin p28 peptide

Cat.No: T80523

Cat.No: T74794

Target: DUB

Cat.No: T74793

Target: DUB

(Asp28)-Glucagon (1-29) (human, rat, porcine)

Cat.No: T83550

Cat.No: T74792

(Asp28)-Exenatide

Cat.No: T76587

Cat.No: T79731

Target: Necroptosis

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03153	IL-27 Protein, Mouse, Recombinant (His) p28,Il30,IL-27,白介素,interleukin 27,IL-27p28...	Mouse	HEK293 Cells
	IL-27 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.5 kDa and the accession number is O35228&Q8K3I6.
TMPY-03142	IL-27 Protein, Human, Recombinant (His) IL27p28,IL-27,白介素,IL27A,interleukin 27,p28...	Human	CHO Cells
	IL-27 Protein, Human, Recombinant (His) is expressed in CHO mammalian cells with His tag. The predicted molecular weight is 56 kDa and the accession number is NP_005746.2&NP_663634.2.
TMPJ-00703	Gankyrin Protein, Human, Recombinant PSMD10,Gankyrin,26S Proteasome Non-ATPase Regulatory Subunit...	Human	E. coli
	Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblastoma protein by CDK4 to enhance the ubiquitinylation of p53 by MDM2. Gankyrin is also involved in progression of esophageal squamous cell carcinoma. Gankyrin plays an oncogenic role especially in early stages of human epatocarcinogenesis.
TMPY-03343	EIF3K Protein, Human, Recombinant (His & GST) PRO1474,eukaryotic translation initiation factor 3, subunit ...	Human	Baculovirus Insect Cells
	EIF3K is a member of the eIF3 subunit K family. It is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 4S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). It stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. EIF3K i...
TMPH-01002	BCAP31 Protein, Human, Recombinant (GST) Bap31,BCAP31,p28,DXS1357E,Protein CDM,6C6-AG tumor-...	Human	E. coli
	BCAP31 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 54.5 kDa and the accession number is P51572.
TMPH-00455	OBP28 Protein, Culex quinquefasciatus, Recombinant (His)	Culex quinquefasciatus	P. pastoris (Yeast)
	N/A. OBP28 Protein, Culex quinquefasciatus, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 16.1 kDa and the accession number is B0XC79.
TMPH-00454	OBP28 Protein, Culex quinquefasciatus, Recombinant (His & Myc)	Culex quinquefasciatus	E. coli
	N/A. OBP28 Protein, Culex quinquefasciatus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 22 kDa and the accession number is B0XC79.

重组蛋白

IL-27 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-03153

Species: Mouse

Expression System: HEK293 Cells

IL-27 Protein, Human, Recombinant (His)

Cat.No: TMPY-03142

Species: Human

Expression System: CHO Cells

Gankyrin Protein, Human, Recombinant

Cat.No: TMPJ-00703

Species: Human

Expression System: E. coli

EIF3K Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03343

Species: Human

Expression System: Baculovirus Insect Cells

BCAP31 Protein, Human, Recombinant (GST)

Cat.No: TMPH-01002

Species: Human

Expression System: E. coli

OBP28 Protein, Culex quinquefasciatus, Recombinant (His)

Cat.No: TMPH-00455

Species: Culex quinquefasciatus

Expression System: P. pastoris (Yeast)

OBP28 Protein, Culex quinquefasciatus, Recombinant (His & Myc)

Cat.No: TMPH-00454

Species: Culex quinquefasciatus

Expression System: E. coli

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