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7

抑制剂 & 化合物

11

天然产物

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Cat. No. Product Name Target Signaling Pathways
T35044 Velaresol

BW 12C79,BW 12C,BW-12C79,BW12C79,BW-12C

Velaresol (BW12C, BW12C79) is an oxygenated hemoglobin stabilizer that, in addition to stabilizing oxygenated hemoglobin, protects sickle cells from calcium-mediated dehydration.
T32523 Lachnanthocarpone

Lachnanthocarpone is a member of the 6-oxygenated phenylphenalenones.
T19166 8-Keto-berberine

Others Others
8-Keto-berberine is a non-naturally occurring 11, 12-oxygenated protoberberine. It is a derivative from naturally occurring 9, 10-oxygenated protoberberine.
T35918 N-Arachidonoyl Taurine

N-Arachidonoyl taurine is an arachidonoyl amino acid. It is oxygenated by 12(S)- and 15(S)-lipoxygenase and is converted to 12-HETE-taurine (12-HETE-T) in murine resident peritoneal macrophages. N-Arachidonoyl taurine is an activator of the transient receptor potential vanilloid (TRPV) channels TRPV1 and TRPV4 (EC50s = 28 and 21 μM, respectively). It increases calcium flux in HIT-T15 pancreatic β-cells and INS-1 rat islet cells when used at a concentration of 10 μM and increases insulin secretio...
T35983 Carotenoid Mixture

Carotenoid mixture is a mixture of carotenoids that contains the antioxidative and anti-inflammatory carotenoid capsanthin and the antioxidative vitamin A precursor β-carotene , as well as additional carotenoids and carotenoid esters.1,2,3,4 1.Kim, J.S., Lee, W.M., Rhee, H.C., et al.Red paprika (Capsicum annuum L.) and its main carotenoids, capsanthin and β-carotene, prevent hydrogen peroxide-induced inhibition of gap-junction intercellular communicationChem. Biol. Interact.254146-155(2016) 2.Na...
T36132 3β-OH-7-Oxocholenic Acid

3β-OH-7-Oxocholenic acid is a bile acid.1 It is also a metabolite of 7β-hydroxy cholesterol in rats. Conjugated forms of 3β-OH-7-oxocholenic acid have been found in the urine of patients with Neimann-Pick disease type C.2,3 |1. Norii, T., Yamaga, N., and Yamasaki, K. Metabolism of 7β-hydroxycholesterol-4-14C in rat. Steroids 15(3), 303-326 (1970).|2. Alvelius, G., Hjalmarson, O., Griffiths, W.J., et al. Identification of unusual 7-oxygenated bile acid sulfates in a patient with Niemann-Pick dise...
T37971 12-oxo-13-HOME

12-oxo-13-HOME is an oxylipin derived from linoleic acid .1It is formedviaa 13-HpODE intermediate that is produced by lipoxygenase-mediated metabolism of linoleic acid.2,3,112-oxo-13-HOME has been found in corn and sunflower seedlings.4 1.Ogorodnikova, A.V., Gorina, S.S., Mukhtarova, L.S., et al.Stereospecific biosynthesis of (9S,13S)-10-oxo-phytoenoic acid in young maize rootsBiochim. Biophys. Acta1851(9)1262-1270(2015) 2.Veldink, G.A., and Vliegenthart, J.F.G.The enzymic conversions of 13-hydr...

化合物

Velaresol
Cat.No: T35044
Synonym: BW 12C79,BW 12C,BW-12C79,BW12C79,BW-12C
Target:
Lachnanthocarpone
Cat.No: T32523
Synonym:
Target:
8-Keto-berberine
Cat.No: T19166
Synonym:
Target: Others
N-Arachidonoyl Taurine
Cat.No: T35918
Synonym:
Target:
Carotenoid Mixture
Cat.No: T35983
Synonym:
Target:
3β-OH-7-Oxocholenic Acid
Cat.No: T36132
Synonym:
Target:
12-oxo-13-HOME
Cat.No: T37971
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T5S1133 Ganoderic acid D

灵芝酸D,灵芝酸 D

Apoptosis; Sirtuin Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
Ganoderic acid D 是高度氧化的四环三萜,是灵芝的主要活性成分,可诱导 HeLa 人宫颈癌细胞凋亡。它上调 SIRT3的蛋白质表达并通过 SIRT3 诱导脱乙酰化的亲环蛋白 D 。它抑制结肠癌细胞的能量重编程,包括结肠癌细胞中的葡萄糖摄取,乳酸、丙酮酸和乙酰辅酶的产生。
TQ0001 1,4-Cineole

Isocineole,1,4-桉叶素

Endogenous Metabolite; TRP/TRPV Channel Membrane transporter/Ion channel; Metabolism
1,4-Cineole (Isocineole) 是天然广泛分布的含氧单萜烯,存在于桉树油中,可激活人TRPM8和TRPA1。
T5147 Polygalaxanthone XI

Others Others
Polygalaxanthone XI 是一种氧杂蒽酮糖苷,分离自 Polygala tenuifolia 皮质,可用于研究祛痰及促进精神安定类。
T72643 Saccharothrixin F

Saccharothrixin F 是一种高度氧化的糖丝菌,具有抗菌和抗炎活性。
T32549 Lamiophlomiol A

Lamiophlomiol A is a highly oxygenated iridoid isolated from the roots of Lamiophlomis rotata.
T73780 11β-Hydroxyandrosterone

11β-Hydroxyandrosterone 是 11β-hydroxyandrostenedione 的 11-氧化雄激素代谢物。
T10524 β-Cryptoxanthin

(3R)-β-Cryptoxanthin

Others Others
β-Cryptoxanthin is isolated from Satsuma mandarin orange with an anti-stress effect. It is an oxygenated carotenoid and an antioxidant.
T83584 (±)-Lavandulol

(±)-Lavandulol为一不对称的单萜醇,能由米根霉(Rhizopus oryzae)真菌转化为其对应氧化代谢产物。
TN1655 Ganoderal A

Others Others
The oxygenated sterols( 26-oxygenosterols ganoderol A, ganoderol B, ganoderal A, and ganoderic acid Y) from G. lucidum can inhibit cholesterol biosynthesis via conversion of acetate or mevalonate as a precursor of cholesterol.
T75562 Ganoderic acid GS-1

Ganoderic acid GS-1 是一种高度氧化的羊毛甾烷型三萜类化合物,具有抗 HIV-1蛋白酶活性,IC50为 58 μM。
T82338 Ganoapplanoid F

Ganoapplanoid F,一种三萜类化合物,源自Ganoderma applanatum,具有抑制脂肪细胞脂质积累的功能,适用于肥胖研究领域。

天然产物

Ganoderic acid D
Cat.No: T5S1133
Synonym: 灵芝酸D,灵芝酸 D
Target: Apoptosis, Sirtuin
1,4-Cineole
Cat.No: TQ0001
Synonym: Isocineole,1,4-桉叶素
Target: Endogenous Metabolite, TRP/TRPV Channel
Polygalaxanthone XI
Cat.No: T5147
Synonym:
Target: Others
Saccharothrixin F
Cat.No: T72643
Synonym:
Target:
Lamiophlomiol A
Cat.No: T32549
Synonym:
Target:
11β-Hydroxyandrosterone
Cat.No: T73780
Synonym:
Target:
β-Cryptoxanthin
Cat.No: T10524
Synonym: (3R)-β-Cryptoxanthin
Target: Others
(±)-Lavandulol
Cat.No: T83584
Synonym:
Target:
Ganoderal A
Cat.No: TN1655
Synonym:
Target: Others
Ganoderic acid GS-1
Cat.No: T75562
Synonym:
Target:
Ganoapplanoid F
Cat.No: T82338
Synonym:
Target:
TargetMol Loading
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