Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9127 |
MYLS22
|
Others | Others |
MYLS22 是视神经萎缩 1 的选择性抑制剂。它通过影响 NFkB 活性和血管生成基因表达抑制血管生成,靶向作用于内皮细胞 OPA1 ,减少肿瘤的生长。 | |||
T63272 |
Edralbrutinib
TG-1701 |
BTK | Angiogenesis; Tyrosine Kinase/Adaptors |
Edralbrutinib (TG-1701) 是有效的BTK抑制剂,具有抗癌活性,可用于治疗肿瘤、免疫系统疾病、血液及淋巴系统疾病。Edralbrutinib可用于研究膜性肾小球肾炎和视神经脊髓炎。 | |||
T77416 |
Opicinumab
BIIB033 |
Others | Others |
Opicinumab (BIIB033) 是一种新型抗 LINGO-1 的单克隆抗体,可用于预防和延缓急性视神经炎和复发性多发性硬化。 | |||
T8644 |
Elamipretide Triacetate
Elamipretide TriTFA |
Others | Others |
Elamipretide Triacetate (Elamipretide TriTFA) 是一种芳香族阳离子四肽,可轻松穿透细胞膜并短暂定位于线粒体内膜,在此与心磷脂结合。它已用于研究 Leber 遗传性视神经病变治疗的试验。 | |||
T21509 |
CA 074
|
Cysteine Protease | Proteases/Proteasome |
CA 074 是一种高效的组织蛋白酶B (cathepsin B) 抑制剂, Ki 值为2 to 5 nM。CA 074 抑制灵长类动物缺血性海马神经元死亡,可减轻 SJL/J 小鼠诱导的实验性自身免疫性脑脊髓炎的视网膜病变和视神经炎。 | |||
T76713 |
Inebilizumab
MEDI 551,MT-0551,16C4-aFuc,VIB-0551 |
Others | Others |
Inebilizumab 是一种人源化抗 CD19 单克隆抗体,对 B 细胞具有增强的抗体依赖细胞介导的细胞毒性。Inebilizumab 可用于治疗多发性硬化和视神经脊髓炎等一些与 CD19的B细胞相关的一系列自身免疫性疾病。 | |||
T73457 |
DN-1289
|
DNA Alkylation | DNA Damage/DNA Repair |
DN-1289 是一种可口服可通过血脑屏障且具有选择性高效性的抑制剂,对双亮氨酸拉链激酶 (DLK)的 IC50 值为17 nM,对 亮氨酸拉链轴承激酶 (LZK)的 IC50 值为 40 nM。DN-1289 对小鼠模型中视神经挤压 (ONC) 诱导的 p-c-Jun 有显著的抑制作用。 | |||
T23985 |
Dextramycine
Dextramycin,(+)-Chloramphenicol,Dextromycetin,L-threo-Chloramphenicol |
||
Dextramycine is an optic isomer of chloramphenicol. | |||
T25107 |
Arginylphenylalaninamide
Rfamide,Arg-phe-NH2 |
||
Arginylphenylalaninamide, an FMRamide fragment, may be utilized as a neurotransmitter or neuromodulator by optic lobe neurons of different types. | |||
T65489 |
Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride
|
||
Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride is used as a probe for luminescent detection and quantitation of oxygen (absorption λmax=455 nm, luminescence λmax=613 nm). It is also used for fibre optic sensors. At the same time, Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride can be used in studies on oxygen in skin and skin tumors as well as measurement of oxygen flux through the skin. | |||
T69600 |
Spermidine-d6
|
||
Spermidine-d6 is intended for use as an internal standard for the quantification of spermidine by GC- or LC-MS. Spermidine is an endogenous polyamine. It is formed from putrescine by spermidine synthase. Spermidine (25 µM) inhibits the activity of the human inward-rectifying potassium channel Kir2.3 in a patch-clamp assay. It induces autophagy in HeLa cells when used at a concentration of 100 µM and increases the lifespan of D. melanogaster, yeast, and C. elegans. Spermidine (30 mM in the drinki... |