Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8506 |
THPP-1
|
PDE | Metabolism |
THPP-1 是一种 SGC 推荐的化学探针, 是一种口服具有活性的磷酸二酯酶10A 抑制剂,其对人和大鼠的Ki 分别为 1 nM 和 1.3 nM。它的药理学特性良好。 | |||
T5474 |
D159687
D 159687 |
PDE | Metabolism |
D159687 是一种PDE4D 选择性抑制剂。 | |||
T16816 |
S 18986
|
GluR | Neuroscience |
S 18986是一种选择性、可口服活性、能渗透大脑的AMPA型受体阳性异构体调节剂,在啮齿动物中展示出增强认知的特性。它在大鼠海马体内诱导去甲肾上腺素和乙酰胆碱的释放,从而提高了对象识别记忆能力。 | |||
T27195 |
DNS-8254
|
||
DNS-8254 is a potent and selective Phosphodiesterase 2 (PDE2) inhibitor for the treatment of Memory Disorders (hPDE2a IC50 = 8 nM, Rat Cl-int = 25.6 uL/min/mg). DNS-8254 demonstrated significant memory enhancing effects in a rat model of novel object reco | |||
T36639 | Donecopride (fumarate hydrate) | ||
Donecopride is a partial agonist of the serotonin (5-HT) receptor subtype 5-HT4E(Ki= 8.5 nM) and an inhibitor of acetylcholinesterase (AChE; IC50= 16 nM).1It is selective for AChE over butyrylcholinesterase (BChE; IC50= 3,530 nM) but does bind to 5-HT2Band sigma-2 (σ2) receptors (Ki= 1.6 nM for both) in a panel of 42 neurotransmitter receptors and transporters. Donecopride induces release of soluble amyloid precursor protein-α (sAPP-α) in COS-7 cells transiently expressing 5-HT4with an EC50value... | |||
T81335 |
PZ-1922
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
PZ-1922(Compound 16),是能穿透大脑屏障的5-HT6R/5-HT3R拮抗剂,其Ki值分别为17 nM和0.45 nM。该化合物还能可逆地抑制MAO-B(pIC50:8.93)。在大鼠的新物体识别(NOR)测试中,PZ-1922逆转了Scopolamine (SCOP)诱导的记忆缺陷;同样,在T迷宫测试中,它防止了Aβ诱发的记忆衰退。 | |||
T75137 | BAY-747 | ||
BAY-747 (BAY 1165747) 为一种通过口服生效且具有脑渗透性的sGC刺激剂。它能可逆地逆转L-NAME所诱导的记忆障碍并在大鼠中增强认知功能。BAY-747还可在有意识状态下降低正常血压及自发性高血压大鼠(SHR)的血压。此外,BAY-747在mdx/mTRG2小鼠模型中改善了与Duchenne肌营养不良症(DMD)相关的骨骼肌功能。 | |||
T37370 |
Amyloid-β (25-35) Peptide (human) (trifluoroacetate salt)
|
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Amyloid-β (25-35) (Aβ (25-35)) is an 11-residue fragment of the Aβ protein that retains the physical and biological characteristics of the full length peptide. It forms fibrils that react to thioflavin T and Congo red and are organized in a cross-β arrangement of β-strands similar to Aβ (1-40) and Aβ (1-42) fibrils. Aggregated Aβ (25-35) decreases the viability of rat adrenal PC12 cells. It also decreases the viability of primary rat cortical neurons at concentrations ranging from 1 nM to 30 μM.... |