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Search Results for " neuraminidase "

39

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T76172	Neuraminidase
	Neuraminidase（Exo-α-sialidase）为一种常用于生化研究的外唾液酸酶，能够在唾液酸（N-acetylneuraminic）与临近糖残基间切断α-酮甙键（α-ketosidic）。该酶源自黏膜病原体，作为一种调整宿主感染反应的毒力因子。
T8555	Neuraminidase-IN-1 Novel NA Inhibitor,Compound Y-1	Others; Influenza Virus	Microbiology/Virology; Others
	Neuraminidase-IN-1 (Compound Y-1) 是一种神经氨酸酶抑制剂，其IC50值为 0.21 μM，具有抗H1N1流感病毒的活性。
T62346	Neuraminidase-IN-7
	Neuraminidase-IN-7 (compound 4b) 是一种噻吩衍生物，是一种神经氨酸酶 (neuraminidase) 的有效抑制剂 (IC50: 0.03 μM)。Neuraminidase-IN-7 对 A/chicken/Hubei/327/2004 (H5N1-DW) 表现出显著的抗病毒作用 (EC50: 1.59 μM)。Neuraminidase-IN-7 具有潜力进行流感的研究。
T61509	Neuraminidase-IN-8
	Neuraminidase-IN-8 (Compound 6d) 是一种有效的神经氨酸酶 (neuraminidase) 抑制剂，其IC50值为 0.027 μM。Neuraminidase-IN-8 具有抗流感活性。
T74774	Neuraminidase-IN-16
	Neuraminidase-IN-16 (Compound 43b) 是一种有效的神经氨酸酶 (neuraminidase) 抑制剂，对 H5N1、H5N8、H1N1、H3N2、H5N1–H274Y 和 H1N1–H274Y 的神经氨酸酶抑制作用的 IC50分别为 0.031、0.15、0.25、0.60、0.63 和 10.08 μM。
T78675	Neuraminidase-IN-13	Influenza Virus	Microbiology/Virology
	Neuraminidase-IN-13 (Compound 10) 为神经氨酸酶抑制剂，展现抗病毒功效及低细胞毒性。该化合物显著抑制Vero细胞中NDV感染，其作用机制为阻断病毒颗粒从受感染细胞的释放。
T74766	Neuraminidase-IN-12
	NDV-IN-1 是一种具有高神经氨酸酶抑制活性的抗病毒剂。 NDV-IN-1 对新城疫病毒 (NDV) 具有体外抑制活性。NDV-IN-1 通过阻止病毒颗粒从感染细胞中释放出来，显著抑制 Vero 细胞的 NDV 感染。
T60939	Neuraminidase-IN-6
	Neuraminidase-IN-6 (Compound 5c) 是1,3,4-triazole-3-acetamide 的衍生物。Neuraminidase-IN-6 是神经氨酸酶的有效抑制剂，IC50值为 0.11 μM。神经氨酸酶 (NA) 是抗流感药物开发的理想靶点。
T63233	Neuraminidase-IN-10
	Neuraminidase-IN-10 是神经氨酸酶 (neuraminidase) 抑制剂，表现出抗流感作用，能够作用于 H1N1 (IC50: 2.6 nM)、H5N1 (IC50: 5.1 nM) 和 H5N8 (IC50: 1.65 nM)。
T63175	Neuraminidase-IN-3
	Neuraminidase-IN-3 (compound 23d) 是一种流感神经氨酸酶 (NA) 的有效抑制剂，能够作用于 H1N1 (IC50: 0.73 nM)、H5N1 (IC50: 0.26 nM) 和 H5N8 NAs (IC50: 0.63 nM)。
T63754	Neuraminidase-IN-9
	Neuraminidase-IN-9 (Compound 6l) 是流感病毒神经氨酸酶 (influenzaneuraminidase) 的有效抑制剂，能够作用于 H5N1 (IC50: 0.12 μM)、H5N2 (IC50: 0.049 μM) 和 H5N6 (IC50: 0.16 μM)。
T62345	Neuraminidase-IN-4
	Neuraminidase-IN-4 (Compound 4b) 是一种 neuraminidase 的有效抑制剂 (EC50: 1.59 μM)。神经氨酸酶（NA）是治疗流感的重要靶点。Neuraminidase-IN-4 对 A/chicken/Hubei/327/2004 (H5N1-DW) 表现出显著的抗病毒作用。
T64274	Neuraminidase-IN-11
	Neuraminidase-IN-11 (15e) 是一种选择性的、有效的神经氨酸酶 (NA) 抑制剂，能够作用于 H1N1 病毒的神经氨酸酶 (IC50: 4.7 nM)、H5N1 病毒的神经氨酸酶 (IC50: 8.46 nM) 和 H5N8 病毒的神经氨酸酶 (IC50: 1.5 nM)。
T61394	Neuraminidase-IN-5
	Neuraminidase-IN-5 (Compound 5b) 是一种有效的 neuraminidase 抑制剂，IC50为 0.02 μM。神经氨酸酶（NA）是开发抗流感药物的有希望的靶点。Neuraminidase-IN-5 是一种二氢呋喃香豆素衍生物化合物。
T9124	Laninamivir octanoate 辛酸拉尼米韦,CS-8958	Influenza Virus	Microbiology/Virology
	Laninamivir octanoate (CS-8958) 是一种长效流感神经氨酸酶抑制剂，是Laninamivir 的前药，具有优异的抗流感病毒活性。
T5186	Oseltamivir acid GS 4071,oseltamivir carboxylate,奥斯他伟酸,Ro 64-0802	Influenza Virus; Drug Metabolite	Metabolism; Microbiology/Virology
	Oseltamivir acid (GS 4071) 是Oseltamivir phosphate 的活性代谢产物，是一种有效的流感病毒神经氨酸酶抑制剂和 GS4071 的前药。
T21339	Peramivir RWJ 270201,BCX1812,BCX 1812,帕拉米韦,RWJ270201
	Peramivir, a neuraminidase inhibitor, acts as a transition-state analogue inhibitor of influenza neuraminidase and thereby preventing new viruses from emerging from infected cells. It is used as an antiviral drug for the treatment of influenza.
T2522	Peramivir Trihydrate RWJ-270201,帕拉米韦三水合物,S-021812,BCX-1812,RWJ 270201 trihydrate,BCX 1812 trihydrate	Influenza Virus	Microbiology/Virology
	Peramivir Trihydrate (RWJ-270201) 是一种高效、选择性和口服有效的流感病毒神经氨酸酶(NA)抑制剂，对 9 个亚型 NA 抑制作用的IC50值为 0.9-4.3 nM。它是一种环戊烷衍生物，具有抗甲型和乙型流感病毒的活性。
T2529	Zanamivir 扎那米韦,GG167	Influenza Virus; Antibiotic	Microbiology/Virology
	Zanamivir (GG167) 是神经氨酸酶抑制剂，对于流感病毒 A 和B 的IC50值分别为0.95 nM 和2.7 nM。
T21486	X-NeuNAc X-Neu5Ac,5-Bromo-4-chloro-3-indolyl-alpha-D-N-acetylneuraminic acid sodium salt	Others	Others
	X-NeuNAc (5-Bromo-4-chloro-3-indolyl-alpha-D-N-acetylneuraminic acid sodium salt) 是细菌表达系统中神经氨酸酶活性的一种新的显色测定底物。
T15707	Laninamivir (4S,5R,6R)-5-乙酰氨基-4-胍基-6-((1R,2R)-2,3-二羟基-1-甲氧基丙基)-5,6-二氢-4H-吡喃-2-甲酸,R 125489	Influenza Virus	Microbiology/Virology
	Laninamivir (R 125489) 是一种流感神经氨酸酶抑制剂，对流感病毒 H12N5 NA (N5)，pH1N1 N1 NA (p09N1) 和 A/RI/5+/1957 H2N2 N2 (p57N2) 的 IC50值分别为 0.90 nM、1.83 nM 和 3.12 nM。
T27797	Laninamivir Octanoate Monohydrate CS8958,CS-8958,CS 8958,Inavir
	Laninamivir Octanoate Monohydrate is a neuraminidase inhibitor.
T28209	NSC65847
	NSC65847 is a novel dual inhibitor of viral and Streptococcus pneumoniae neuraminidase.
T38120	4-MUNANA 4-Methylumbelliferyl-N-acetyl-α-D-Neuraminic Acid sodium salt
	4-MUNANA(4-Methylumbelliferyl-N-acetyl-α-D-Neuraminic Acid sodium salt) 是用于神经氨酸酶 (neuraminidase) 活性测定的荧光底物，是神经氨酸酶底物类似物。
T68964	Neuraminin
	Neuraminin inhibits viral but not bacterial neuraminidase.
T2529L	Zanamivir hydrate D01937,J1.917.534K
	Zanamivir hydrate is neuraminidase inhibitors. It is used worldwide for the treatment and prophylaxis of influenza caused by influenza A and B viruses.
T40140	Zanamivir-Cholesterol Conjugate
	Zanamivir-cholesterol conjugate is an extended-duration neuraminidase inhibitor highly effective against drug-resistant influenza strains.
T37510	Oseltamivir-acetate
	Oseltamivir-acetate, an impurity of Oseltamivir, is a recommended neuraminidase inhibitor for both the treatment and prophylaxis of influenza A and B[1][2].
T61557	Influenza A virus-IN-4
	Influenza A virus-IN-4 (compound 23b), a derivative of Oseltamivir, is a highly effective neuraminidase inhibitor. It exerts potent inhibitory effects on influenza viruses [1].
T25618	Laninamivir trifluoroacetate
	Laninamivir trifluoroacetate 是一种抗病毒化合物，用于治疗和预防甲型流感病毒和乙型流感病毒。它是一种通过鼻吸入给药的长效神经氨酸酶抑制物。
T62197	Influenza virus-IN-4
	Influenza virus-IN-4 (compound 11e) 是一种流感病毒神经氨酸酶的有效抑制剂，能够作用于 H5N1 (IC50: 3.4 μM)、H5N2 (IC50: 0.094 μM)、H5N6 (IC50: 0.79 μM)、H5N8 (IC50: 0.077 μM)。Influenza virus-IN-4 能够抑制 NA（神经氨酸酶），并具有低细胞毒性(CC50>200 μM)。Influenza virus-IN-4 在1500 mg/kg 时，对小鼠没有明显的毒性。
T60663	Oseltamivir acid methyl ester	Others	Others
	Oseltamivir acid methyl ester 是Oseltamivir acid 的前体形式，可通过羧酸酯酶1 (CES1) 转化为Oseltamivir acid。Oseltamivir acid 是神经氨酸酶抑制剂和抗病毒剂。
T73347	BCX-1898
	BCX-1898 是一种环戊烷衍生物，是口服有效的，选择性的流感病毒神经氨酸酶 (influenza virus neuraminidase) 抑制剂。BCX-1898 具有抗病毒活性，对 MDCK 细胞中的甲型流感病毒 (H1N1、H3N2、H5N1) 和乙型流感病毒复制的 EC50值为 <0.01-21 μM。BCX-1898 显示出对小鼠流感模型的保护作用。
T76415L	Asp-Asp-Asp-Asp-Asp-Asp TFA
	Asp-Asp-Asp-Asp-Asp-Asp TFA，一种以聚天冬氨酸形式出现的化合物，与流感病毒神经氨酸酶的催化位点和抗原位点具有特异性关联，此关联取决于特定氨基酸的数量。
T76415	Asp-Asp-Asp-Asp-Asp-Asp
	Asp-Asp-Asp-Asp-Asp-Asp是一种聚天冬氨酸，其特性关键在于流感病毒神经氨酸酶的催化位点及抗原位点的特异性与特殊氨基酸数量的相关性。
T62837	Influenza virus-IN-3
	Influenza virus-IN-3 (compound 9) 是一种选择性流感病毒的有效抑制剂，能够作用于 H5N1 (IC50: 0.88 μM)、H5N2 (IC50: 0.10 μM)、H5N6 (IC50: 5.5 μM)、H5N8 (IC50: 0.51 μM)。Influenza virus-IN-3 具有抗病毒和 NA (神经氨酸酶) 抑制作用，且细胞毒性低 (CC50>200 μM)。
T38118	Zanamivir-13C,15N2 Zanamivir-13C,15N2
	Zanamivir-13C,15N2is intended for use as an internal standard for the quantification of zanamivir by GC- or LC-MS. Zanamivir is a sialic acid analog that inhibits neuraminidase release of newly replicated influenza virus particles.1It has been shown to selectively inhibit the growth of influenza A and B viruses in plaque reduction assays with IC50values ranging from 5 to 14 nM and to directly inhibit influenza A and B virus neuraminidases with IC50values ranging from 0.6 to 7.9 nMin vitro. Intra...
T70207	Pimodivir tosylate
	Pimodivir, also known as VX-787, JNJ-872, is a novel inhibitor of influenza virus replication that blocks the PB2 cap-snatching activity of the influenza viral polymerase complex. VX-787 binds the cap-binding domain of the PB2 subunit with a KD (dissociation constant) of 24 nM as determined by isothermal titration calorimetry (ITC). The cell-based EC50 (the concentration of compound that ensures 50% cell viability of an uninfected control) for VX-787 is 1.6 nM in a cytopathic effect (CPE) assay...
T37295	Ganglioside GM1 Asialo Mixture
	Ganglioside GM1 asialo is a component of cellular lipid rafts and can be formed by the cleavage of the sialic acid residue from ganglioside GM1 by neuraminidase. Ganglioside GM1 asialo is a glycolipid receptor for P. aeruginosa flagellin and stimulates defensive responses in host cells, including extracellular ATP release, calcium mobilization, and ERK1/2 phosphorylation when stimulated by flagellin and an anti-ganglioside GM1 asialo antibody. The percentage of ganglioside GM1 asialo-positive na...

化合物

Neuraminidase

Cat.No: T76172

Neuraminidase-IN-1

Cat.No: T8555

Synonym: Novel NA Inhibitor,Compound Y-1

Target: Others, Influenza Virus

Neuraminidase-IN-7

Cat.No: T62346

Neuraminidase-IN-8

Cat.No: T61509

Neuraminidase-IN-16

Cat.No: T74774

Neuraminidase-IN-13

Cat.No: T78675

Target: Influenza Virus

Neuraminidase-IN-12

Cat.No: T74766

Neuraminidase-IN-6

Cat.No: T60939

Neuraminidase-IN-10

Cat.No: T63233

Neuraminidase-IN-3

Cat.No: T63175

Neuraminidase-IN-9

Cat.No: T63754

Neuraminidase-IN-4

Cat.No: T62345

Neuraminidase-IN-11

Cat.No: T64274

Neuraminidase-IN-5

Cat.No: T61394

Laninamivir octanoate

Cat.No: T9124

Synonym: 辛酸拉尼米韦,CS-8958

Target: Influenza Virus

Oseltamivir acid

Cat.No: T5186

Synonym: GS 4071,oseltamivir carboxylate,奥斯他伟酸,Ro 64-0802

Target: Influenza Virus, Drug Metabolite

Cat.No: T21339

Synonym: RWJ 270201,BCX1812,BCX 1812,帕拉米韦,RWJ270201

Peramivir Trihydrate

Cat.No: T2522

Synonym: RWJ-270201,帕拉米韦三水合物,S-021812,BCX-1812,RWJ 270201 trihydrate,BCX 1812 trihydrate

Target: Influenza Virus

Cat.No: T2529

Synonym: 扎那米韦,GG167

Target: Influenza Virus, Antibiotic

Cat.No: T21486

Synonym: X-Neu5Ac,5-Bromo-4-chloro-3-indolyl-alpha-D-N-acetylneuraminic acid sodium salt

Target: Others

Cat.No: T15707

Synonym: (4S,5R,6R)-5-乙酰氨基-4-胍基-6-((1R,2R)-2,3-二羟基-1-甲氧基丙基)-5,6-二氢-4H-吡喃-2-甲酸,R 125489

Target: Influenza Virus

Laninamivir Octanoate Monohydrate

Cat.No: T27797

Synonym: CS8958,CS-8958,CS 8958,Inavir

Cat.No: T28209

Cat.No: T38120

Synonym: 4-Methylumbelliferyl-N-acetyl-α-D-Neuraminic Acid sodium salt

Cat.No: T68964

Zanamivir hydrate

Cat.No: T2529L

Synonym: D01937,J1.917.534K

Zanamivir-Cholesterol Conjugate

Cat.No: T40140

Oseltamivir-acetate

Cat.No: T37510

Influenza A virus-IN-4

Cat.No: T61557

Laninamivir trifluoroacetate

Cat.No: T25618

Influenza virus-IN-4

Cat.No: T62197

Oseltamivir acid methyl ester

Cat.No: T60663

Target: Others

Cat.No: T73347

Asp-Asp-Asp-Asp-Asp-Asp TFA

Cat.No: T76415L

Asp-Asp-Asp-Asp-Asp-Asp

Cat.No: T76415

Influenza virus-IN-3

Cat.No: T62837

Zanamivir-13C,15N2

Cat.No: T38118

Synonym: Zanamivir-13C,15N2

Pimodivir tosylate

Cat.No: T70207

Ganglioside GM1 Asialo Mixture

Cat.No: T37295

Cat. No.	Product Name	Target	Signaling Pathways
TL0005	3,5-O-Dicaffeoylquinic acid Isochlorogenic Acid A,(-)-3,5-二咖啡酰奎宁酸,(-)-3,5-Dicaffeoyl quinic acid,3,5-Dicaffeoylquinic Acid	Others	Others
	3,5-O-Dicaffeoylquinic acid (Isochlorogenic Acid A) 能够改善由三甲基锡诱导的学习和记忆缺陷。
TN2176	Sanggenol A	Influenza Virus; Antifection	Microbiology/Virology
	Sanggenol A 抑制甲型流感病毒和肺炎球菌神经氨酸酶，因此可作为双重作用的抗感染试剂。
T72732	Massarilactone H
	Massarilactone H 是一种聚酮化合物，是神经氨酸酶抑制剂，IC50值为 8.18 µM。
T81020	Tenaxin I
	Tenaxin I，一种从黄芩提取物中鉴定出的成分，具有神经氨酸酶抑制活性。
TN1066	Filixic acid ABA	Influenza Virus	Microbiology/Virology
	Filixic acid ABA exhibits inhibitory effects on neuraminidase of influenza virus H5N1 with IC50 as 29.57 ± 2.48 μM, it may have anti-influenza virus activity.
TN3995	Erythrabyssin II	Antifection	Microbiology/Virology
	Erythrabyssin II actives against several strains of Staphylococcus and Streptococcus with an MIC range of 0.78-1.56 microg/ml. It inhibits bacterial neuraminidase in a dose-dependent manner with significant inhibition (IC(50)=0.09-3.25 μM).
TN4392	Koaburaside	IL Receptor; TNF; Influenza Virus	Apoptosis; Immunology/Inflammation; Microbiology/Virology
	Koaburaside exhibits antioxidant activity with an IC50 value of 9.0μM, it shows weak inhibitory activity against influenza A neuraminidase. Koaburaside may have anti-allergic inflammatory activity, it can suppress histamine release from mast cells.
TN4108	Ganoderic acid Z	Antifection	Microbiology/Virology
	The binding affinities of ganoderic acid DM and ganoderic acid Z (ÎGbind, -16.83 and-10.99 kcal mol-1) are comparable to that of current commercial drug oseltamivir (-23.62 kcal mol-1);Ganoderic acid DM is a potential source of anti-influenza ingredient, with novel binding pattern and advantage over oseltamivir, it has steric hindrance on the 150 cavity of N1 protein, and exerts activities across the H274Y and N294S mutations, is the attractive candidates of novel neuraminidase (NA) inhibitors....

天然产物

3,5-O-Dicaffeoylquinic acid

Cat.No: TL0005

Synonym: Isochlorogenic Acid A,(-)-3,5-二咖啡酰奎宁酸,(-)-3,5-Dicaffeoyl quinic acid,3,5-Dicaffeoylquinic Acid

Target: Others

Cat.No: TN2176

Target: Influenza Virus, Antifection

Massarilactone H

Cat.No: T72732

Cat.No: T81020

Filixic acid ABA

Cat.No: TN1066

Target: Influenza Virus

Erythrabyssin II

Cat.No: TN3995

Target: Antifection

Cat.No: TN4392

Target: IL Receptor, TNF, Influenza Virus

Ganoderic acid Z

Cat.No: TN4108

Target: Antifection

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