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抑制剂 & 化合物

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天然产物

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Cat. No. Product Name Target Signaling Pathways
T36647 Trastuzumab emtansine

Others Others
Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that combines the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of DM1, a microtubule-inhibitory derivative of maytansine. This compound is utilized in the investigation of advanced breast cancer[1][2].
T18278 Mal-PEG2-VCP-Eribulin

Others Others
Mal-PEG2-VCP-Eribulin is a chemotherapeutic compound comprising an antibody-drug conjugate (ADC) linker (Mal-PEG2-VCP) and the microtubule inhibitor Eribulin[1]. This compound uniquely targets microtubules, offering a novel approach to cancer treatment. Eribulin is specifically utilized in creating targeted Eribulin-based drugs for antibody conjugates[1].
T68232 Epofolate

Epofolate is folate receptor-targeting antimitotic agent with potential antineoplastic activity. Folate receptor-targeted epothilone BMS753493 contains an epothilone moiety linked to a single folate molecule. Mediated through the folate moiety, this agent delivers the antimitotic epothilone component into cells expressing folic acid receptors, frequently upregulated in many types of tumor cells. After ligand-receptor internalization, the epothilone moiety induces microtubule polymerization and s...
T77186 Zilovertamab vedotin

Zilovertamab vedotin (VLS-101) 是一种抗体-活性分子偶联物 (ADC), 主要由人源化单克隆抗体 zilovertamab 和单甲基 vedotin 组成的抗微管细胞毒素。该药物通过与肿瘤细胞表面的ROR1结合, 触发快速内化及向溶酶体的转运, 进而裂解释放单甲基 vedotin, 诱导细胞凋亡。适用于癌症的研究领域。

化合物

Trastuzumab emtansine
Cat.No: T36647
Synonym:
Target: Others
Mal-PEG2-VCP-Eribulin
Cat.No: T18278
Synonym:
Target: Others
Epofolate
Cat.No: T68232
Synonym:
Target:
Zilovertamab vedotin
Cat.No: T77186
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T21351 Maytansine

NSC-153858,NSC153858,Maitansina,NSC 153858,Maitansine,美坦新

Microtubule Associated; Antibiotic Cytoskeletal Signaling; Microbiology/Virology
Maytansine (NSC-153858) 是从变叶美登木中分离的一种高效微管靶向天然产物,可诱导有丝分裂阻滞并在亚纳摩尔浓度杀死肿瘤细胞。

天然产物

Maytansine
Cat.No: T21351
Synonym: NSC-153858,NSC153858,Maitansina,NSC 153858,Maitansine,美坦新
Target: Microtubule Associated, Antibiotic
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