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抑制剂 & 化合物

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天然产物

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Cat. No. Product Name Target Signaling Pathways
T35663 Cortistatin-29 (rat) (trifluoroacetate salt)

Cortistatin-29 is a neuropeptide that is structurally similar to somatostatin-28. It is produced by cleavage of preprocortistatin to procortistatin, which is cleaved at dibasic amino acids to form cortistatin-29 and cortistatin-14 as well as other partial cleavage products. Cortistatin mRNA is expressed in the human brain and in interneurons of the rat hippocampus and cerebral cortex. Cortistatin-29 binds to somatostatin (SST) receptors with IC50 values of 2.8, 7.1, 0.2, 3, and 13.7 nM for SST1-...
T70953 AZ5576 racemate

AZ5576 racemate is a racemic mixture of AZ5576 isomers. AZ5576 is a potent, highly selective, and orally bioavailable inhibitor of Cdk9 that inhibits Cdk9 enzyme activity with an IC50 <5nM and decreases phosphorlyation of Ser2-RNAPII in cells with an IC50 of 96nM. In the MLL-fusion containing acute myeloid leukemia (AML) line, MV411, short-term treatment with AZ5576 led to a rapid dose-dependent decrease in pSer2-RNAPII with concomitant loss of Mcl1 mRNA and protein, resulting in the cleavage a...

化合物

Cortistatin-29 (rat) (trifluoroacetate salt)
Cat.No: T35663
Synonym:
Target:
AZ5576 racemate
Cat.No: T70953
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T17143 Toyocamycin

丰加霉素,Vengicide

Apoptosis; Others; IRE1; Antibiotic; Antifungal Apoptosis; Cell Cycle/Checkpoint; Microbiology/Virology; Others
Toyocamycin (Vengicide) 是放线菌类产生的腺苷类似物,为 X 盒结合蛋白 1 (XBP1) 抑制剂,抑制 IRE1α 诱导的 ATP 依赖性 XBP1 mRNA 的断裂,IC50值为 80 nM。它还诱导凋亡。

天然产物

Toyocamycin
Cat.No: T17143
Synonym: 丰加霉素,Vengicide
Target: Apoptosis, Others, IRE1, Antibiotic, Antifungal
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