17
1
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T15598 |
Isosulfan blue
|
Others | Others |
Isosulfan blue 是用于淋巴管造影中淋巴管识别的蓝色染料,可用于乳腺癌前哨淋巴结活检,但其在乳腺癌手术中有发生过敏反应的可能性。 | |||
T76978 |
Siltuximab
CNTO-328 |
IL Receptor | Immunology/Inflammation |
Siltuximab(CNTO-328) 是一种靶向 IL-6 且具有抗肿瘤活性的单克隆抗体,可用于研究巨大淋巴结增生症 (MCD) 和 COVID-19。 | |||
T36454 |
1-Stearoyl-rac-glycerol
|
||
1-Stearoyl-rac-glycerol is a monoacylglycerol that contains stearic acid at the sn-1 position. 1-Stearoyl-rac-glycerol levels are decreased in tumor tissue in a mouse model of azoxymethane-induced colorectal carcinogenesis. Levels of 1-stearoyl-rac-glycerol are decreased in lung tissue from patients with adenocarcinoma, but are increased in the serum of patients with Buruli ulcer and in the cerebrospinal fluid of patients with the inflammatory demyelinating diseases multiple sclerosis (MS), neur... | |||
T27884 |
LY 183648
LY-183648,LY183648 |
||
LY 183648 has antiestrogenic activity. LY117018 inhibited PAIII metastasis to the gluteal (97%) and iliac lymph nodes (88%). | |||
T23898 |
Clocoumarol
Clocoumarolum,BRN 1264788,DB 112 |
||
Clocoumarol is an anticoagulant that prevents blood clotting. It also can inhibit the dilatation of the spleen and the congestion of lymph nodes. | |||
T35821 |
CAY10721
|
||
CAY10721 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (39% SIRT3 inhibition at 200 μM). Upregulation of SIRT3 transcription is associated with oral squamous cell carcinoma (OSCC) and breast cancer with lymph node involvement, while SIRT3 down-regulation inhibits the growth of OSCC cells and sensitizes them to radiation and chemotherapy. | |||
T41175 |
OB 24 hydrochloride
|
||
OB 24 hydrochloride is a potent and selective heme oxygenase 1 (HO-1) inhibitor (IC50 values are 1.9 and >100 μM for HO-1 and HO-2 respectively), reduces protein carbonylation and reactive oxygen species formation in advanced prostate cancer cells (PCA). Inhibits cell proliferationin vitroand PCA tumor growth and lymph node/lung metastasesin vivo. Synergizes with Taxol. | |||
T75154 | ATU027 | ||
ATU027, 一种可沉默血管内皮中PKN3表达的siRNA, 已在小鼠癌症模型中证明能有效抑制局部肿瘤侵袭及淋巴结和肺转移。 | |||
T79791 |
Immunosuppressant-1
|
Apoptosis | Apoptosis |
Immunosuppressant-1(Compound 31)抑制抗-CD3/抗-CD28共刺激的T细胞增殖,具备免疫抑制活性。该化合物能激活活化的淋巴结细胞中的caspase-3和PARP,从而诱导细胞凋亡(apoptosis)。 | |||
T78458 |
IR 813 tosylate
|
||
IR 813 tosylate, 一近红外(NIR)荧光染料(λex=815 nm,λem=840 nm),适用于小鼠局部淋巴结的可视化。 | |||
T81400 |
Pritumumab
|
||
Pritumumab是一种自然源的人类IgG1kappa单克隆抗体,其最初源于一位宫颈癌患者的区域淋巴结分离得到。该单抗特异性地识别波形蛋白,该蛋白在多种恶性肿瘤细胞表面展现。Pritumumab在胶质母细胞瘤的科研应用中具有潜在价值。 | |||
T1120L2 |
Dacarbazine citrate
DTIC citrate |
||
Dacarbazine citrate is an alkylating agent used to treat cancers of the lymphatic system and malignant melanoma (a type of skin cancer) in patients with certain conditions: islet cell carcinoma (part of the pancreas) Soft tissue sarcoma (cancer of muscles | |||
T60895 | JAK-2/3-IN-3 | ||
JAK-2/3-IN-3 (化合物 ST4j) 可用于研究淋巴源性疾病和白血病。JAK-2/3-IN-3 以时间和剂量依赖性的方式抑制JAK2的自磷酸化并诱导细胞凋亡。JAK-2/3-IN-3 是 JAK2/3 的有效抑制剂,对JAK2和JAK3的IC50值分别为 13.00 和 14.86 nM。 | |||
T37548 |
azido-FTY720
azido-FTY720 |
||
FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5). Down-regulation of S1P1 recept... | |||
T78451 |
Patent Blue V
Acid blue 1 |
||
Patent Blue V(Acid blue 1)是一款应用于眼科的新型生物染料,特别是在进行视网膜切除手术时,用以染色以便去除内限制膜(ILM)。该染料在玻璃体视网膜手术中确保了对视网膜结构的有效标记,从而实现精确去除。光谱分析揭示,Patent Blue V在450 nm以下和600 nm以上具有强烈的吸收特性,展现蓝绿色。此外,它亦作为淋巴管造影术中的追踪剂,在染色活检手术中使用以助于淋巴结的切除。 | |||
T83910 |
S1PL-IN-31
Sphingosine-1-Phosphate Lyase Inhibitor 31,S1PL Inhibitor 31,S1P Lyase Inhibitor 31 |
||
S1PL-IN-31是一种鞘氨醇-1-磷酸(S1P)裂解酶的抑制剂(IC50 = 210 nM),同时也是Smoothened(Smo)受体的对抗剂(IC50 = 440 nM)。在体内,S1PL-IN-31 (每天2 mg/kg)能够防止实验性自身免疫性脑炎(EAE)模型大鼠中,由髓鞘少突胶质细胞糖蛋白(MOG)肽段MOG29-152诱发的颈部及胸部淋巴细胞渗透和神经肌肉虚弱。该化合物降低了大鼠的淋巴细胞总数及CD4+ T细胞、CD8+ T细胞和B细胞的水平。S1PL-IN-31 (每天3及10 mg/kg剂量)在雄性和雌性大鼠心脏和淋巴结中增加了S1P水平,并且在雌性大鼠中降低了心率。 | |||
T35829 | CC-90005 | ||
CC-90005 is a potent, selective and orally active inhibitor of protein kinase C-θ (PKC-θ), with an IC50 of 8 nM. CC-90005 shows selectivity for PKC-θ over PKC-δ (IC50=4440 nM). CC-90005 can inhibit T cell activation by IL-2 expression[1]. CC-90005 shows the exquisite selectivity of CC-90005, with IC50s for all other family members of >3 μM[1].CC-90005 is a moderate inhibitor of both CYP2C9 (IC50=8 μM) and CYP2C19 (IC50=5.9 μM) in human liver microsomes[1].CC-90005 inhibits IL-2 expression in LRS... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5S1550 |
Cinnamyl alcohol
肉桂醇,肉桂醇;beta-苯丙烯醇,Cinnamic Alcohol,Styryl Carbinol |
PPAR | DNA Damage/DNA Repair; Metabolism |
Cinnamyl alcohol (Styryl Carbinol) 是从板栗花中分离得到的一种活性成分,抑制增加的 PPARγ表达,具有抗肥胖作用。 |