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Cat. No. | Product Name | Target | Signaling Pathways |
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T36643 |
PKI-166 hydrochloride
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Potent EGFR-kinase inhibitor (IC50 = 0.7 nM). Displays >3000-fold selectivity against a panel of serine/threonine kinases. Reduces metastasis and angiogenesis in a mouse model of pancreatic cancer. Antihypertensive and orally bioavailable. Bruns et al (2000) Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res. 60 2926 PMID:10850439 |Ulu et al (2013) Epidermal ... | |||
T16549 |
PKI-166
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
PKI-166是一种可口服的EGF-R 酪氨酸激酶抑制剂(IC50 : 0.7 nM),具有有效性和选择性。PKI-166能有效抑制包括胰腺癌在内的多种人类癌细胞的生长和转移。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T3020 |
Sclareol
|
Apoptosis; Others | Apoptosis; Others |
Sclareol 是一种从快乐鼠尾草中分离出来的拉丹型二萜,对多种人类 Y 细胞系具有生长抑制和细胞毒活性,诱导细胞凋亡。 |