Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5045 |
GSK4112
1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate,SR6452 |
Autophagy | Autophagy |
GSK4112 (SR6452) 是一种 Rev-erbα 激动剂,EC50 为 0.4 μM。它也是一种用于核血红素受体 Rev-erbα 的细胞生物学的小分子化学探针。 | |||
T60033 |
SBI993
|
Others | Others |
SBI993 是 SBI-477 的类似物,可用作生物标志物来确认 MondoA 靶基因在体内表达的预期作用。 SBI993 降低肌肉 TAG 水平和肝脂肪变性。 | |||
T39273 |
Lumasiran
ALN-G01 |
||
Lumasiran (ALN-G01), a siRNA product, inhibits hepatic oxalate production by targeting glycolate oxidase. By silencing the gene encoding glycolate oxidase, Lumasiran depletes this enzyme and thereby prevents the synthesis of oxalate, the toxic metabolite directly linked to the clinical manifestations of Primary hyperoxaluria type 1 (PH1). | |||
T79603 |
3,7-DMF
|
TGF-beta/Smad | Stem Cells |
3,7-DMF作为一种口服活性抑制剂,有效抑制了TGF-β1诱导的HSC活化,并通过诱导抗氧化基因及淬灭ROS为研究肝纤维化提供了潜在应用。 | |||
T83721 |
Hexafluoropropylene Oxide Dimer Acid
FRD-903,Perfluoro-2-propoxypropanoic Acid,PFPrOPrA,HFPO-DA |
||
Hexafluoropropylene oxide dimer acid (HFPO-DA)作为一种全氟烷基醚羧酸(PFECA),于HepG2细胞中以250 µM的浓度使用时,可诱导凋亡并增加活性氧种类(ROS)的水平。HFPO-DA以每个蛋4 mg/kg的剂量,会减少孵化鸡右心室壁厚度,增加心率,并诱导肝脏脂肪积累,这些效应可通过敲除过氧化物酶体增殖物激活受体α(Ppara)基因编码实现预防。它减少了斑马鱼胚胎的存活百分比(LC50 = 7,651 mg/L)。在孕妇大鼠给药下,HFPO-DA(250 mg/kg)降低了新生大鼠的平均出生体重、存活时间和血清葡萄糖水平,并增加了血清胆固醇和甘油三酯水平。它已经被发现污染海水和河水。 | |||
T36629 | Givinostat | ||
Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF3056. At 25, 50, and 100 nM, Givinostat reduced IL-1β secretion more than 70%. Givinostat (ITF-2357) suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18. IL-6 secretion decreases to 50% at 50 nM Givinostat, but at 1... |