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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T22106	MLS-573151	CDK; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	MLS-573151 是 GTPase Cdc42 的选择性抑制剂，EC50 为 2 μM。它通过阻止 GTP 与 Cdc42 的结合来发挥作用。
T81135	Sodium caseinates
	Sodium caseinates，作为主要乳蛋白，能诱导粒细胞增殖与活化，同时提高关键细胞因子GM-CSF与G-CSF的血清浓度。该化合物还可引起小鼠粒细胞的生成。
TP1597L	Secretoneurin, rat acetate Secretoneurin, rat acetate(149146-12-3 Free base)	Others	Others
	Secretoneurin, rat acetate 是一种 33 个氨基酸的多肽，由分泌粒蛋白 II (SgII) 的蛋白水解加工产生。它在体内和体外诱导大鼠纹状体中的多巴胺释放，它对单核细胞和嗜酸性粒细胞有很强的趋化作用，但对粒细胞没有。
T27408	Gea 3162 Gea3162,Gea-3162
	Gea 3162 is a potent inhibitor of ADP-induced platelet aggregation in platelet rich plasma (PRP). GEA 3162 stimulates cGMP production in granulocytes, platelets, and polymorphonuclear leukocytes.
T39009	CAP18 (rabbit) CAP18 (rabbit)
	CAP18 (rabbit) is a 37 amino acid antimicrobial peptide derived from rabbit granulocytes. It exhibits extensive antimicrobial activity against both Gram-positive (IC50, 130-200 nM) and Gram-negative (IC50, 20-100 nM) bacteria. Thus, CAP18 (rabbit) holds promise for the study and advancement of bacterial sepsis research.
T79597	LUF7690
	LUF7690（Compound 9）是一种针对人A3AR（hA3AR）的可点击、基于共价亲和力的探针（AfBP）。该探针被应用于识别和表征粒细胞及其他细胞中的hA3AR。
T35541	Lipoxygenin
	Lipoxygenin is an inhibitor of 5-lipoxygenase (5-LO) with an IC50value of 5 μM for inhibition of 5-LO product synthesis in isolated human granulocytes stimulated with the cation ionophore A23187 .1It inhibits hedgehog-dependent signaling in Shh-LIGHT2 cells and TGF-β-, activin A-, bone morphogenic protein (BMP)-, or Wnt-dependent signaling in HEK293T cells (IC50s = 9.3, 3.2, 8.2, 9.6, and 3.7 μM, respectively, in luciferase reporter assays). Lipoxygenin (5 and 10 μM) increases levels of troponin...
T38309	LL-37 amide (trifluoroacetate salt)
	LL-37 is a cationic and α-helical antimicrobial peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and is upregulated in psoriatic lesions. It inhibits growth of Gram-positive E. coli D21 and Gram-negative B. megatarium in a concentration-dependent manner and LL-37 expression is induced in A549 epithelial cells, alveolar macrophages, neutrophils, and monocyte-derived macrophages following M. tuberculosis infection. LL-37 binds sheep erythrocytes coated with S. ...
T14210	Amelubant BIIL 284	LTR	Immunology/Inflammation
	Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity[1]. Amelubant (BIIL 284) is a potent, oral and long acting LTB4 receptor antagonist, negligibly binds to LTB4 receptor, with Kis of 221 nM and 230 nM

化合物

Secretoneurin, rat acetate

Cat.No: TP1597L

Synonym: Secretoneurin, rat acetate(149146-12-3 Free base)

Target: Others

Gea 3162

Cat.No: T27408

Synonym: Gea3162,Gea-3162

Target:

CAP18 (rabbit)

Cat.No: T39009

Synonym: CAP18 (rabbit)

LL-37 amide (trifluoroacetate salt)

Synonym: BIIL 284

Target: LTR

Cat. No.	Product Name	Target	Signaling Pathways
TN6057	1-Methyl-2-[(Z)-6-undecenyl]-4(1H)-quinolone (Z)-1-Methyl-2-(undec-6-enyl)quinolin-4(1H)-one
	(Z)-1-Methyl-2-(undec-6-enyl)quinolin-4(1H)-one shows strong inhibitory activity on leukotriene biosynthesis in human polymorphonuclear granulocytes, and it is very effective against mycobacteria.
TN2552	1-Methyl-2-nonylquinolin-4(1H)-one	Others	Others
	1-Methyl-2-nonylquinolin-4(1H)-one has anti-inflammatory activity, it exhibits inhibitory activity on leukotriene biosynthesis in a bioassay using human polymorphonuclear granulocytes, with IC50 values of 12.1 microM.

天然产物

1-Methyl-2-[(Z)-6-undecenyl]-4(1H)-quinolone

Cat.No: TN6057

Synonym: (Z)-1-Methyl-2-(undec-6-enyl)quinolin-4(1H)-one

Target:

1-Methyl-2-nonylquinolin-4(1H)-one

Cat.No: TN2552

Synonym:

Target: Others

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