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Cat. No.	Product Name	Target	Signaling Pathways
T67737	gp120-α4β7 binding inhibitor 11	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	gp120-α4β7 binding inhibitor 11是一种抗HIV 药物。gp120-α4β7 binding inhibitor 11干扰HIV 相关糖蛋白gp12G 与整合素α4β7的结合（IC50=1.64nM）。
T60871	gp120-IN-1
	gp120-IN-1 (compound 4e) 是 HIV-1 gp120蛋白的有效抑制剂，CC50值为 100.90 μM，IC50值为 2.2 μM。gp120-IN-1 抑制 gp120 蛋白介导的病毒进入细胞。gp120-IN-1 具有抗 HIV-1 活性。gp120-IN-1 在 SUP-T1 细胞中具有剂量依赖性细胞毒性。
T60714	gp120-IN-2
	gp120-IN-2 (compound 4i) 显示出抗 HIV-1 活性。它是 HIV-1 gp120的有效抑制剂，IC50值为 7.5 μM，CC50值为 112.93 μM。gp120-IN-2 在癌细胞 SUP-T1 中表现出剂量依赖性的细胞毒性。
T16276	NBD-556	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	NBD-556是一种 CD4 模拟物，识别 HIV-1 包膜蛋白 gp120 并诱导 gp120 重组，类似于 CD4 结合，可阻断 gp120-CD4 的相互作用。
T76537	GP120, HIV-1 MN
	GP120，HIV-1MN 是一种肽。GP120,HIV-1MN 可用于 HIV 感染的研究。
T6418	BMS-378806 BMS378806,BMS-806,1-[(2R)-4-苯甲酰基-2-甲基-1-哌嗪基]-2-(4-甲氧基-1H-吡咯并[2,3-B]吡啶-3-基)-1,2-乙二酮	gp120/CD4; HIV Protease	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	BMS-378806 (BMS-806) 是一种 HIV-1 抑制剂，可选择性抑制 HIV-1 gp120 结合到 CD4 受体，EC50为 0.85-26.5 nM。
TP1785L	Peptide T acetate(106362-32-7 free base)	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Peptide T acetate(106362-32-7 free base) 是一种来自 HIV-1 gp120 V2 区域的八肽。它是一种合成八肽，其可能的作用机制是 gp120 对 CD4 受体的竞争性抑制以及与血管肠肽受体的结合和抑制细胞因子作用。
T4665	Temsavir BMS626529	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Temsavir (BMS626529) 是一种新型附着抑制剂，靶向 HIV-1 gp120 并阻止其与 CD4+ T 细胞结合。
T71665	INCB-9471	HIV Protease; CCR	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	INCB-9471 是一种 CCR5 拮抗剂，具有抗HIV活性，抑制 HIV-1 gp120 之间的相互作用。
T10570	Fostemsavir Tris BMS-663068 Tris	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Fostemsavir Tris (BMS-663068 Tris) 是一种 HIV-1附着抑制剂。
T3523	Fostemsavir BMS-663068,磷坦姆沙韦	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Fostemsavir (BMS-663068) 是 BMS-626529 的原药，可抑制 HIV-1 与细胞 CD4 受体的结合，能结合gp120。
T23108	Ophiobolin C	Others	Others
	inhibitor of human CCR5 binding to HIV-1 gp120
T80580	Zinlirvimab 10-1074
	Zinlirvimab是一种IgG1-λ2类人源化HIV中和抗体，专一性靶向HIV-1 gp120包膜糖蛋白(IIIB gp120 V3环)。
T30532	BMS-585248 CHEMBL236995,CIO2TZZ9H1,BMS 585248,UNII-CIO2TZZ9H1
	BMS-585248 is a highly effective HIV-1 adhesion inhibitor that targets the viral envelope protein gp120.
TP2401	Peptide T amide D-Ala(1)-peptide T amide
	Peptide T amide is an octapeptide segment of HIV envelope gp120 and is used in AIDS therapy.
T72099	Carbomethoxycarbonyl-D-Pro-D-Phe-OBzl
	Carbomethoxycarbonyl-D-Pro-D-Phe-OBzl (化合物 (CPF(LL)) 是一种 HIV-1抑制剂。Carbomethoxycarbonyl-D-Pro-D-Phe-OBzl 能与 gp120相互作用以阻断 gp120与 CD4的结合，并保留 CD4依赖的 T 细胞功能。
T69371	BMS 378806
	BMS-378806 is an orally bioavailable HIV-1 inhibitor that interferes with gp120-CD4 interaction.
T62340	NBD-14189
	NBD-14189 是一种有效的 HIV-1 进入拮抗剂，能够作用于 HIV-1HXB2 假病毒 (IC50: 89 nM)。NBD-14189 能够结合 HIV-1 gp120，并具有显著的抗病毒作用 (EC50<200 nM)。
T71094	CD4 (81-92)
	CD4 (81-92) is a peptide that was previously found to inhibit gp120 binding, HIV-1 infectivity, and syncytium formation.
TP1785	Peptide T
	Peptide T is an octapeptide from the V2 region of HIV-1 gp120. Peptide T is a synthetic octapeptide whose possible mechanism of action is the competitive inhibition of gp120 to the CD4 receptor as well as binding to vasointestinal peptide receptors and in
T81295	Retrocyclin-1
	Retrocyclin-1是一种θ防御素，具有识别并结合含碳水化合物表面分子的能力，能够保护细胞抵御HIV-1感染。该化合物对胎球蛋白、gp120（Kd=35.4 nM）、CD4（Kd=31 nM）以及半乳糖神经酰胺（Kd=24.1 nM）展现出高度亲和性。
T62299	NBD-14270
	NBD-14270 是一种有效的 HIV-1 进入拮抗剂，能够作用于 50 株 HIV-1 假型病毒 (IC50: 89 nM)。NBD-14270 是一种吡啶类似物，细胞毒性低 (CC50>100 μM)。NBD-14270 能够结合 HIV-1 gp120 并表现出显著的抗病毒活性 (EC50<200 nM)。
TP1873	Peptide T TFA
	Peptide T (TFA) is an octapeptide derived from the V2 region of HIV-1 gp120. It serves as a ligand for the CD4 receptor, effectively inhibiting the binding of HIV to the CD4 receptor.
T68789	N-(3-Phenyl-2-propenyl)-1-deoxynojirimycin
	The effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin (ppDNM) on the lectin binding to HIV-1 glycoprotein was analyzed by using biotinylated lectins of various sugar specificities as probes. ppDNM potentially inhibited HIV-1-induced syncytium formation and viral infectivity of HIV-1 without cytotoxicity. The lectin binding assay showed that ppDNM treatment reduced Con A binding to gp120 of HIV-1.
TP1910	CALP1
	Cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site; produces CaM-dependent activation of phosphodiesterase. Also binds to cytoplasmic sites on other Ca2+ channels, including NMDA and HIV-1 gp120-activated channels, inhibit
T68842	Complestatin
	Complestatin is a compound extracted from Streptomyces lavendulae mycelia; on acid hydrolysis yields D-4-hydroxyphenylglycine & D-3,5-dichloro-4-hydroxyphenylglycine & acidic chromophore; inhibits gp120-CD4 binding. It is isolated from the culture broth of Streptomyces and has anti-HIV-1 activity. It has a role as a metabolite, an antimicrobial agent and an anti-HIV-1 agent.
T7624	DAPTA DAPTA(TFA),D-Ala-peptide T-amide,Adaptavir	HIV Protease; CCR	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	DAPTA (Adaptavir) 是一种合成肽，是 CCR5抑制剂，有抗 HIV 的活性。
T77792	HIV Peptide T
	HIV Peptide T（Peptide T），这种合成的八肽是HIV感染治疗中的一种抗病毒药物，其主要通过竞争性抑制gp120（HIV表面蛋白）与CD4受体的相互作用，同时与血管肠肽（vasointestinal peptide, VIP）受体同源结合并且阻断细胞因子的产生与作用来发挥功效。
T36185	Globotriaosylceramides (hydroxy) (porcine)
	Globotriaosycleramides are glycosphingolipids found in mammalian cell membranes that are synthesized from lactosylceramides . They act as receptors for Shiga and Shiga-like toxins in vitro and in vivo. Globotriaosylceramides accumulate in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease, a lysosomal storage disorder characterized by a deficiency in the enzyme α-galactosidase A. G...
T36186	Globotriaosylceramides (porcine)
	Globotriaosycleramides are glycosphingolipids found in mammalian cell membranes that are synthesized from lactosylceramides . They act as receptors for Shiga and Shiga-like toxins in vitro and in vivo. Globotriaosylceramides accumulate in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease, a lysosomal storage disorder characterized by a deficiency in the enzyme α-galactosidase A. G...
T37874	Feglymycin
	Feglymycin is a 13-amino acid peptide originally isolated from Streptomyces that has antibacterial and antiviral activities. It is active against Gram-positive bacteria (MICs = 32-64 μg/ml) and inhibits HIV viral replication in H9 cells (IC50 = ~5 μM). Feglymycin is also active against clinical isolates of HIV-1 from clades A-D, A/E, and G (EC50s = 0.5-6.7 μM). It interacts with gp120 and inhibits HIV-1 NL4.3 binding to human soluble CD4 (EC50 = 4.4 μM) and to CD4+ SupT1 T cells by 74.5% when us...
T38103	Defensin HNP-3 (human) (trifluoroacetate salt)
	Defensin HNP-3 is a peptide secreted by human polymorphonuclear leukocytes (PMNs) that has antimicrobial properties. It induces lysis of mammalian cells when used at a concentration of 25 μg/mL. It also inhibits growth of E. faecalis (ED50 = 100 nM) and clinical isolates of P. aeruginosa (MIC90 = 4 μM). HNP-3 binds to recombinant HIV-1 envelope glycoprotein (gp120) and human CD4 (Kds = 52.8 and 34.9 nM, respectively). It also binds to recombinant, immobilized human surfactant protein D (SP-D; Kd...

化合物

gp120-α4β7 binding inhibitor 11

Cat.No: T67737

Target: HIV Protease

Cat.No: T60871

Cat.No: T60714

Cat.No: T16276

Target: HIV Protease

GP120, HIV-1 MN

Cat.No: T76537

Cat.No: T6418

Synonym: BMS378806,BMS-806,1-[(2R)-4-苯甲酰基-2-甲基-1-哌嗪基]-2-(4-甲氧基-1H-吡咯并[2,3-B]吡啶-3-基)-1,2-乙二酮

Target: gp120/CD4, HIV Protease

Peptide T acetate(106362-32-7 free base)

Cat.No: TP1785L

Target: Others, HIV Protease

Cat.No: T4665

Synonym: BMS626529

Target: HIV Protease

Cat.No: T71665

Target: HIV Protease, CCR

Fostemsavir Tris

Cat.No: T10570

Synonym: BMS-663068 Tris

Target: HIV Protease

Cat.No: T3523

Synonym: BMS-663068,磷坦姆沙韦

Target: HIV Protease

Cat.No: T23108

Target: Others

Cat.No: T80580

Synonym: 10-1074

Cat.No: T30532

Synonym: CHEMBL236995,CIO2TZZ9H1,BMS 585248,UNII-CIO2TZZ9H1

Peptide T amide

Cat.No: TP2401

Synonym: D-Ala(1)-peptide T amide

Carbomethoxycarbonyl-D-Pro-D-Phe-OBzl

Cat.No: T72099

Cat.No: T69371

Cat.No: T62340

Cat.No: T71094

Cat.No: TP1785

Cat.No: T81295

Cat.No: T62299

Cat.No: TP1873

N-(3-Phenyl-2-propenyl)-1-deoxynojirimycin

Cat.No: T68789

Cat.No: TP1910

Cat.No: T68842

Cat.No: T7624

Synonym: DAPTA(TFA),D-Ala-peptide T-amide,Adaptavir

Target: HIV Protease, CCR

Cat.No: T77792

Globotriaosylceramides (hydroxy) (porcine)

Cat.No: T36185

Globotriaosylceramides (porcine)

Cat.No: T36186

Cat.No: T37874

Defensin HNP-3 (human) (trifluoroacetate salt)

Cat.No: T38103

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