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Cat. No.	Product Name	Target	Signaling Pathways
T3489	Dasabuvir ABT-333,达塞布韦	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Dasabuvir (ABT-333) 是丙型肝炎病毒非结构蛋白 5B 的非核苷抑制剂，是一种 RNA 依赖性 RNA 聚合酶，具有抗 HCV 的潜在活性。
T15282	Filibuvir PF-00868554	HCV Protease; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	Filibuvir (PF-00868554) 是 HCV NS5B RNA 依赖性 RNA 聚合酶的选择性非共价抑制剂。 Filibuvir 抑制基因型 1a 和 1b 复制子，EC50 为 59 nM。
T6229	Daclatasvir Daklinza,达卡他韦,EBP 883,达拉他韦,BMS-790052	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Daclatasvir (EBP 883) 是一种高度选择性的 HCV NS5A 抑制剂，EC50 为 9-50 pM，适用于细胞培养中的多种 HCV 复制子基因型和 JFH-1 基因型 2a 感染性病毒。
T15573	Inarigivir soproxil SB9200	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Inarigivir soproxil (SB9200) 是一种先天免疫激动剂。它还显示出针对耐药丙型肝炎病毒 (HCV) 变体的有效抗病毒活性。在基因型 1 HCV 复制子系统细胞中， HCV 1a/1b 的 EC50 为 2.2 和 1.0 μM。
T7158	Ombitasvir 奥比他韦,ABT-267	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Ombitasvir (ABT-267) 是丙型肝炎病毒非结构蛋白 5A 的口服生物可利用的强效抑制剂。对 HCV 基因型 1 至 5 的 EC50 为 0.82 至 19.3 pM，对基因型 6a 的 EC50 为 366 pM。
T3334	Velpatasvir GS-5816,维帕他韦	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Velpatasvir (GS-5816) 是一种的 HCV NS5A 抑制剂。它也是 SARS-CoV 3CLpro 的抑制剂，IC50为 2.16 μM。
T3226	Paritaprevir ABT-450,Veruprevir,帕利瑞韦	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Paritaprevir (ABT-450) 是一种口服生物可利用的合成酰基磺酰胺抑制剂，可抑制丙型肝炎病毒 (HCV) 蛋白酶复合物，由非结构蛋白 3 和 4A (NS3/NS4A) 组成，对 HCV 基因型 1 具有潜在活性。给药后，paritaprevir 可逆地结合 HCV NS3/NS4A 蛋白酶的活性中心和结合位点，并阻止 NS3/NS4A 蛋白酶介导的多蛋白成熟。这会破坏病毒蛋白的加工和病毒复制复合物的形成，从而抑制病毒在 HCV 基因型 1 感染的宿主细胞中的复制。 NS3 是一种丝氨酸蛋白酶，对于 HCV 多蛋白内多个位点的蛋白水解切割至关重要，并且在 HCV 核糖核酸 (RNA) 复制过程中起关键作用。 NS4A 是 NS3 的激活因子。 HCV 是属于黄病毒科的一种小的、有包膜的单链 RNA 病毒，感染与肝细胞癌 (HCC) 的发展有关。
T8675	Vaniprevir	Others	Others
	Vaniprevir is a macrocyclic hepatitis C virus NS3/4a protease inhibitor and is active against both the genotype 1 and genotype 2 NS3/4a protease enzymes. vaniprevir has good plasma exposure and excellent liver exposure in multiple species.
T16715	Furaprofen 呋喃洛芬,R803	Others	Others
	Furaprofen is substantially more potent against genotype 1a and 1b replicons (EC50, ~30 nM) than against the genotype 2a replicon (EC50:1000 nM). Furaprofen is an effective HCV replication inhibitor.
T30584	BRD9092 BRD 9092,BRD-9092
	BRD9092 is an enhancer of reactive oxygen species that are nontoxic or cause genotype-selective cell death.
T24476	MK-6169 MK6169
	MK-6169 is an effective Pan-Genotype Hepatitis C Virus NS5A inhibitor. It also has Optimized Activity against Common Resistance-Associated Substitutions.
T73834	NS5A-IN-2	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	NS5A-IN-2 (Compound 33)为一种高效的NS5A抑制剂，对HCV基因型1b展现出极高效力，并对基因型3a (GT 3a) 亦具备增强活性与良好的代谢稳定性。
T19627	Ciluprevir BILN 2061ZW,BILN 2061,BILN-2061ZW,BILN-2061,BILN2061ZW,BILN2061
	Ciluprevir is an effective and selective HCV NS3 protease inhibitor with proven antiviral effect in humans. Ciluprevir may be an antiviral agent for individuals infected with non-genotype-1 HCV. In vitro sensitivity studies with Ciluprevir showed a decrea
T73223	NS5A-IN-3	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	NS5A-IN-3 (Compound 15) 为高效NS5A抑制剂，对HCV基因型1b显示出高效力，并对基因型3a (GT 3a) 活性提升以及展现出良好的代谢稳定性。NS5A-IN-3相较于daclatasvir，对基因型1b具有更高的耐药门槛。
T35043	Vedroprevir GS9451,GS 9451,GS-9451
	Vedroprevir, also known as GS9451, is a selective hepatitis C virus (HCV) NS3 protease inhibitor in the development of the treatment of genotype 1 (GT1) HCV infection.
T27461	GSK2336805 GSK 2336805,GSK-2336805,JNJ-56914845,GSK-805,GSK805
	GSK-2336805 is a HCV NS5A inhibitor. GSK2336805 retained activity on chimeric replicons containing NS5A patient sequences from genotype 1 and patient and consensus sequences for genotypes 4 and 5 and part of genotype 6.
T15631	JTK-853	Others	Others
	JTK-853 is a novel, non-nucleoside inhibitor of Hepatitis C Virus (HCV) polymerase. It also displays effective antiviral activity in HCV replicon cells (EC50s: 0.38 and 0.035 µM in genotype 1a H77 and 1b Con1 strains, respectively).
T75241	Ledipasvir hydrochloride GS-5885 hydrochloride
	Ledipasvir (GS-5885) hydrochloride 是抗HCV NS5A 的高效抑制剂，对GT1a 和 GT1b 复制子抑制作用显著，其EC50值仅为34 pM 和 4 pM。此外，Ledipasvir hydrochloride 还能抑制 SARS-CoV 3CLpro， IC50 为1.62 μM。
T21456	Grazoprevir hydrate Grazoprevir,MK5172,MK 5172,MK-5172
	Grazoprevir, a second generation hepatitis C virus protease inhibitor acting at the NS3/4a protease targets, has good activity against a range of hepatitis C virus genotype variants, including some that are resistant to most currently used antiviral medic
T30581	BRD5459 BRD-5459,BRD 5459
	BRD5459 is a kind of reactive oxygen species enhancer that is non-toxic or leads to genotype selective cell death. Brd5459 can selectively kill cancer cells in various in vitro and in vivo models.
T70846	Deleobuvir sodium
	Deleobuvir sodium is the salt form of Deleobuvir, also known as BI207127, a non-nucleoside hepatitis C virus NS5B polymerase inhibitor for the treatment of hepatitis C. Deleobuvir was tested in combination regimens with pegylated interferon and ribavirin, and in interferon-free regimens with other direct-acting antiviral agents including faldaprevir. Deleobuvir showed that a triple combination of deleobuvir, faldaprevir, and ribavirin performed well in HCV genotype 1b patients. Efficacy fell b...
T74625	HCV-IN-41
	HCV-IN-41 (compound 4) 是一种高效的丙肝病毒 (HCV)抑制剂，对 HCV1b、2a、3a 和 4a 的 EC50分别为 0.006762 nM、5.183 nM、1.365 nM 和 142.2 nM。HCV-IN-41 能降低 HCVRNA 的复制。
T63593	Dasabuvir sodium
	Dasabuvir (ABT-333) sodium 是非核苷丙型肝炎病毒 (HCV) 聚合酶抑制剂。Dasabuvir sodium 对 HCV NS5B 基因编码的 RNA 依赖性 RNA 聚合酶 (RNA polymerase) 表现出抑制作用。Dasabuvir sodium 能够抑制基因型 1a (菌株 H77) 复制子 (EC50: 7.7 nM) 和 1b (菌株 Con1) 复制子 (EC50: 1.8 nM)。
T38131	(E)-10-Hydroxynortriptyline
	(E)-10-Hydroxynortriptyline (E-10-OH-NT) is a metabolite of Nortriptyline . Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1]. [1]. Shimoda K, et al. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. J Clin Psychopharmacol. 2002 Aug;22(4):371-8. [2]. Shimoda K, et al. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology ...

化合物

Cat.No: T3489

Synonym: ABT-333,达塞布韦

Target: HCV Protease

Cat.No: T15282

Synonym: PF-00868554

Target: HCV Protease, DNA/RNA Synthesis

Cat.No: T6229

Synonym: Daklinza,达卡他韦,EBP 883,达拉他韦,BMS-790052

Target: HCV Protease

Inarigivir soproxil

Cat.No: T15573

Synonym: SB9200

Target: HCV Protease

Cat.No: T7158

Synonym: 奥比他韦,ABT-267

Target: HCV Protease

Cat.No: T3334

Synonym: GS-5816,维帕他韦

Target: HCV Protease, SARS-CoV

Cat.No: T3226

Synonym: ABT-450,Veruprevir,帕利瑞韦

Target: HCV Protease

Cat.No: T8675

Target: Others

Cat.No: T16715

Synonym: 呋喃洛芬,R803

Target: Others

Cat.No: T30584

Synonym: BRD 9092,BRD-9092

Cat.No: T24476

Synonym: MK6169

Cat.No: T73834

Target: HCV Protease

Cat.No: T19627

Synonym: BILN 2061ZW,BILN 2061,BILN-2061ZW,BILN-2061,BILN2061ZW,BILN2061

Cat.No: T73223

Target: HCV Protease

Cat.No: T35043

Synonym: GS9451,GS 9451,GS-9451

Cat.No: T27461

Synonym: GSK 2336805,GSK-2336805,JNJ-56914845,GSK-805,GSK805

Cat.No: T15631

Target: Others

Ledipasvir hydrochloride

Cat.No: T75241

Synonym: GS-5885 hydrochloride

Grazoprevir hydrate

Cat.No: T21456

Synonym: Grazoprevir,MK5172,MK 5172,MK-5172

Cat.No: T30581

Synonym: BRD-5459,BRD 5459

Deleobuvir sodium

Cat.No: T70846

Cat.No: T74625

Dasabuvir sodium

Cat.No: T63593

(E)-10-Hydroxynortriptyline

Cat.No: T38131

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