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Search Results for " ganglionic "

18

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T2141	Mecamylamine hydrochloride 盐酸美加明,Inversine,Mevasin	AChR	Neuroscience
	Mecamylamine hydrochloride (Mevasin) 是一种易穿过血脑屏障的烟碱拮抗剂，用作高血压的神经节阻滞剂，具有抗神经疾病作用。
T0296	Pempidine 潘必定,1,2,2,6,6-Pentamethylpiperidine,Perolysen,Pyrilene	Others; AChR	Neuroscience; Others
	Pempidine (1,2,2,6,6-Pentamethylpiperidine) 是一种口服具有活力的神经节阻断试剂，用于研究高血压。
TP1325L	Gastrin-Releasing Peptide, human(TFA)	Others	Others
	Gastrin-Releasing Peptide, human(TFA） (93755-85-2 free base) 是一种调节性人类肽，可引发胃泌素释放并调节胃酸分泌和肠道运动功能。支配胃G 细胞的迷走神经节后纤维释放GRP，刺激G 细胞释放胃泌素。
T62893	SM-2470	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	SM-2470 是一种α1-adrenoceptor拮抗剂，具有降压活性，可减低前神经节肾上腺神经活性和主动脉降压神经活性。SM-2470 具有降胆固醇活性，可抑制胆固醇吸收。
T30141L	Arpenal HCl Arpenal hydrochloride
	Arpenal HCl is a ganglionic blocking agent which may be useful in the treatment of bronchial asthma.
T30141	Arpenal
	Arpenal is a ganglionic blocking agent which may be useful in the treatment of bronchial asthma.
T68867	Trimethaphan camsylate
	Trimethaphan camsylate is a nicotinic antagonist that has been used as a ganglionic blocker in hypertension.
T1236	Pentolinium Tartrate Pendine,酒石酸喷托铵,Tensilest,Recuryl	AChR	Neuroscience
	Pentolinium Tartrate (Pendine) 是烟碱拮抗剂，已被用作高血压的神经节阻滞剂。
T69939	Hexamethonium tartrate
	Hexamethonium tartrate is a nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
T69022	Hexamethonium Free Base
	Hexamethonium Free Base is a nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
T68858	Chlorisondamine chloride
	Chlorisondamine chloride is a nicotinic antagonist used primarily as a ganglionic blocker in animal research. It has been used as an antihypertensive agent but has been supplanted by more specific drugs in most clinical applications.
T69120	Pempidine tartrate
	Pempidine tartrate is a nicotinic antagonist most commonly used as an experimental tool. It has been used as a ganglionic blocker in the treatment of hypertension but has largely been supplanted for that purpose by more specific drugs.
T68992	Pempidine HCl
	Pempidine HCl is a nicotinic antagonist most commonly used as an experimental tool. It has been used as a ganglionic blocker in the treatment of hypertension but has largely been supplanted for that purpose by more specific drugs.
T50109	Guanethidine
	Guanethidine 于1959年合成，被认为可以通过干扰神经节后交感神经纤维中的化学递质物质的代谢来降低血压。
TP1325	Gastrin-Releasing Peptide, human
	Gastrin-Releasing Peptide, human is a regulatory human peptide that elicits gastrin release and regulates gastric acid secretion and enteric motor function. The post-ganglionic fibers of the vagus nerve that innervate the G cells of the stomach release GRP, which stimulates the G cells to release gastrin.
T69019	Mecamylamine 美加明
	Mecamylamine 是一种具有口服活性，非选择性，非竞争性的nAChR 拮抗剂。Mecamylamine 也是一种神经节阻滞剂，可穿过血脑屏障。Mecamylamine 可用于神经疾病，高血压，抗抑郁的研究。
T36554	TMB 8 (hydrochloride)
	TMB 8 is a non-competitive antagonist of nicotinic acetylcholine receptors (nAChRs) with IC50 values of 390 and 350 nM, respectively, for human muscle-type and α3β4 subunit-containing ganglionic nAChRs expressed in TE671/RD or SH-SY5Y cells. It inhibits nicotine-induced dopamine release from rat brain synaptosomes (IC50 = 480 nM). TMB 8 also reduces calcium availability in smooth and skeletal muscle, blocking the contractile response in isolated rabbit aortic strip when used at a concentration o...
T12738	Rivanicline hemioxalate RJR-2403 hemioxalate,(E)-Metanicotine hemioxalate	Others	Others
	Rivanicline hemioxalate (RJR-2403 hemioxalate; (E)-Metanicotine hemioxalate) 是一种神经元烟碱受体 (neuronal nicotinic receptor) 激动剂，对 α4β2 亚型有高度选择性(Ki= 26 nM)，比对于 α7 受体的选择性高1000倍(Ki=3.6 μM)。

化合物

Mecamylamine hydrochloride

Cat.No: T2141

Synonym: 盐酸美加明,Inversine,Mevasin

Target: AChR

Cat.No: T0296

Synonym: 潘必定,1,2,2,6,6-Pentamethylpiperidine,Perolysen,Pyrilene

Target: Others, AChR

Gastrin-Releasing Peptide, human(TFA)

Cat.No: TP1325L

Target: Others

Cat.No: T62893

Target: Adrenergic Receptor

Cat.No: T30141L

Synonym: Arpenal hydrochloride

Cat.No: T30141

Trimethaphan camsylate

Cat.No: T68867

Pentolinium Tartrate

Cat.No: T1236

Synonym: Pendine,酒石酸喷托铵,Tensilest,Recuryl

Target: AChR

Hexamethonium tartrate

Cat.No: T69939

Hexamethonium Free Base

Cat.No: T69022

Chlorisondamine chloride

Cat.No: T68858

Pempidine tartrate

Cat.No: T69120

Cat.No: T68992

Cat.No: T50109

Gastrin-Releasing Peptide, human

Cat.No: TP1325

Cat.No: T69019

Synonym: 美加明

TMB 8 (hydrochloride)

Cat.No: T36554

Rivanicline hemioxalate

Cat.No: T12738

Synonym: RJR-2403 hemioxalate,(E)-Metanicotine hemioxalate

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T83454	13-Hydroxylupanine hydrochloride Hydroxylupanine hydrochloride
	13-Hydroxylupanine是甜羽扇豆中一种典型的生物碱。它具有阻断神经节传递、降低心肌收缩力以及收缩子宫平滑肌的作用。
TN6028	Gardneramine
	Gardneramine has a mild central depressive effect. Gardneramine and hirsutine show a local anesthetic action, they also can inhibit the ganglionic transmission of the dog urinary bladder and that the blockade of the nicotinic receptor plays a main role.

天然产物

13-Hydroxylupanine hydrochloride

Cat.No: T83454

Synonym: Hydroxylupanine hydrochloride

Cat.No: TN6028

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