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126

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T77698	hCYP3A4 Fluorogenic substrate 1	Others	Others
	hCYP3A4 Fluorogenic substrate 1 是邻苯二甲酰亚胺衍生物，对 COX 表现出低活性。
T83759	MMP-3 Fluorogenic Substrate TFA Mca-RPKPVE-Nval-WR-K(Dnp)-NH2,Matrix Metalloproteinase-3 Fluorogenic Substrate,Stromelysin-1 Fluorogenic Substrate
	MMP-3 fluorogenic substrate 是一种针对基质金属蛋白酶-3（MMP-3）的荧光底物。当被MMP-3切割后，7-甲氧基香豆素-4-乙酰基（Mca）会释放并且其荧光可用于量化MMP-3活性。Mca的激发/发射峰值分别为328/420 nm。
T37021	Enteropeptidase Fluorogenic Substrate
	Enteropeptidase fluorogenic substrate is a substrate for enteropeptidase that contains a 7-amino-4-trifluoromethylcoumarin (AFC) moiety. Enteropeptidase is a serine protease expressed in the proximal small intestine of higher animals that converts inactive trypsinogen to active trypsin by endoproteolytic cleavage. Enteropeptidase recognizes the highly specific amino acid sequence DDDDK on the fluorogenic substrate and cleaves after the lysine residue, releasing the AFC moiety. Enteropeptidase ac...
T35880	Renin Fluorogenic Substrate
	The renin fluorogenic substrate consists of the normal peptide substrate for renin which has been linked to the fluorophore EDANS at one end and to a non-fluorescent quenching molecule (Dabcyl) at the other. After cleavage by renin, the product (peptide-EDANS) is brightly fluorescent and can be easily analyzed using an excitation wavelength of 340 nm and emission wavelengths of 485-510 nm.
T37022	Enteropeptidase Fluorogenic Substrate (trifluoroacetate salt)
	Enteropeptidase fluorogenic substrate is a substrate for enteropeptidase that contains a 7-amino-4-trifluoromethylcoumarin (AFC) moiety. Enteropeptidase is a serine protease expressed in the proximal small intestine of higher animals that converts inactive trypsinogen to active trypsin by endoproteolytic cleavage.1,2Enteropeptidase recognizes the highly specific amino acid sequence DDDDK on the fluorogenic substrate and cleaves after the lysine residue, releasing the AFC moiety. Enteropeptidase ...
T78625	Z-Ala-Arg-Arg-AMC Z-ARR-AMC,Fluorogenic Proteasome Substrate	Proteasome	Proteases/Proteasome; Ubiquitination
	Z-Ala-Arg-Arg-AMC (FluorogenicProteasomeSubstrate) 作为荧光底物，专用于检测蛋白酶体中的胰蛋白酶样活性。
T18888	4-Methylumbelliferyl phosphate 4-甲基伞形酮磷酸酯,4-MUP	Others	Others
	4-Methylumbelliferyl phosphate (4-MUP) 是碱性磷酸酶的荧光底物。
TD0081	EDANS EDANS acid [5-((2-Aminoethyl)amino)naphthalene-1-sulfonic acid],EDANS酸,1,5-EDANS,EDANS acid [5-((2-Aminoethyl)amino)napht	Others	Others
	EDANS (EDANS acid [5-((2-Aminoethyl)amino)naphthalene-1-sulfonic acid]) 是新型的淬灭荧光底物 (fluorogenic substrate)，可利用共振能量转移，分析逆转录病毒蛋白酶。
T37571	4-Methylumbelliferyl-β-D-Glucopyranoside MU-GLU,4-MUG,4-MU-GLU,4-MU-β-Gluc,4-甲基伞形酮酰-Β-D-吡喃葡糖酸苷	Others	Others
	4-Methylumbelliferyl-β-D-Glucopyranoside (4-MU-GLU) 是β-glucosidase 的荧光底物，可用于β-glucosidase 活性的测定，期间释放出高荧光的 4-methylumbelliferyl (4-MU)，发射波长为 445-454 nm。4-MU 激发波长值与 pH 值有关，在 pH 值为 4.6、7.4 和 10.4 时分别为 330、370 和 385 nm。
TP1326	Ac-DEVD-AFC	Others	Others
	Ac-DEVD-AFC 是荧光底物 (λex=400 nm, λem=530 nm)。
T18912	ADHP 10-乙酰基-3,7-二羟基吩嗪,10-Acetyl-3,7-dihydroxyphenoxazine	Others	Others
	ADHP (10-Acetyl-3,7-dihydroxyphenoxazine) 是荧光过氧化物酶底物，其λex=530 nm，λem=590 nm。
T64341	H-β-Ala-AMC TFA	Others	Others
	H-β-Ala-AMC TFA 是氨基肽酶的底物之一。
T18887	4-Methylumbelliferyl-β-D-glucuronide hydrate 4-甲基伞形酮-Β-D-葡糖苷酸二水合物,MUG	Others	Others
	4-Methylumbelliferyl-β-D-glucuronide hydrate (MUG) 是一种荧光底物 (λex=362 nm，λem=445 nm)。
T11221	ERAP1-IN-1	Others	Others
	ERAP1-in-1 是一种内质网氨基肽酶 1 (ERAP1) 抑制剂，能竞争性地抑制 ERAP1 对代表性生物底物九聚物肽的作用。
T8556	Z-Gly-Gly-Arg-AMC TFA (66216-78-2 free base) Z-Gly-Gly-Arg-AMC TFA	Others	Others
	Z-Gly-Gly-Arg-AMC TFA (66216-78-2 free base) 是一种凝血酶特异性荧光底物，用于检测 PRP 和贫血小板血浆 (PPP) 中的凝血酶生成。
T37504L	Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base) Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)
	Cathepsin D and E FRET Substrate acetate 是组织蛋白酶 D 和 E 的荧光底物，但不适用于 B、H 或 L。Cathepsin D and E FRET Substrate acetate 可用于组织蛋白酶 D 和 E 研究的机理研究。
T20684	2',7'-Dichlorofluorescein diacetate Diacetyldichlorofluorescein,Leuco-dcf diacetate,Dcfh-DA,双氯荧光黄乙酸乙酯,DCFDA	Others	Others
	2',7'-Dichlorofluorescein diacetate (Diacetyldichlorofluorescein) 是一种可渗透细胞的荧光探针，可用于检测一氧化氮和活性氧以及确定总体氧化应激的程度。
T37192	4-Methylumbelliferyl-α-D-Galactopyranoside 4MU-α-Gal	Others	Others
	4-Methylumbelliferyl-α-D-Galactopyranoside (4MU-α-Gal) (4-MU-α-Gal)是α-半乳糖苷酶的荧光底物。除了用于表征新的α-半乳糖苷酶外，4-MU-α-Gal 还用于评估与法布里病相关的α-半乳糖糖苷酶活性的缺乏。
T33795	OMFP 3-OMFP
	OMFP is a fluorogenic substrate for phosphatase.
T18993	Fluorescein di(β-D-galactopyranoside) FDG	Others	Others
	Fluorescein di(β-D-galactopyranoside) is a fluorogenic substrate for β-galactosidase (λem=535 nm, λex=485 nm).
T19047	PL553	Others	Others
	PL553 is a specific and high-affinity fluorogenic substrate of Leukotriene A4 hydrolase (λmax: 210 nm; λem: 410 nm).
T18937	CUG 3-Carboxyumbelliferyl-β-D-galactopyranoside	Others	Others
	CUG is a fluorogenic substrate (λex=386, λem=445 nm, ε=32K).
T29485	7-Lysylalanyl-4-methylcoumarinamide
	7-Lysylalanyl-4-methylcoumarinamide is a Fluorogenic substrate for dipeptidyl aminopeptidase.
TP1099	M-2420 Methoxycoumarin-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys-dinitrophenyl
	M-2420 is a fluorogenic substrate designed specifically for the β-secretase site found in the Swedish mutation of the amyloid precursor protein (APP).
T39729	HIV Protease Substrate 1
	HIV Protease Substrate 1 is a fluorogenic compound that offers insights into the enzymatic activity of HIV protease, making it a valuable tool for studying this aspect.
T38933	HKYellow-AM (6/12-mixture)
	HKYellow-AM (6/12-mixture) is a fluorogenic probe, which can be used for sensitive and specific detection of peroxynitrite.
T82016	Janelia Fluor® 526, SE JF526, SE,JF526, NHS
	Janelia Fluor 526, SE (JF526,SE) 是带有 NHS 酯基的黄色荧光染料，作为荧光配体的多功能平台，适用于遗传编码的自标记蛋白以及内源性结构染色。
TP1799	Z-Gly-Gly-Arg-AMC
	Z-Gly-Gly-Arg-AMC is a specific fluorogenic substrate utilized for assessing thrombin generation in Platelet-Rich Plasma (PRP) and Platelet-Poor Plasma (PPP), with a particular focus on thrombin activity.
TP1368	Ac-Leu-Arg-AMC
	Ac-Leu-Arg-AMC is a fluorogenic peptide substrate.
T80107	Tos-Gly-Pro-Lys-AMC
	Tos-Gly-Pro-Lys-AMC为特异性类胰蛋白酶荧光肽底物，通常用于酶活性检测。
T80110	Ac-VRPR-AMC	Caspase	Apoptosis; Proteases/Proteasome
	Ac-VRPR-AMC为特异性荧光metacaspase底物，常用以测定metacaspase活性。
T76268	Mca-VDQVDGW-Lys(Dnp)-NH2
	Mca-VDQVDGW-Lys(Dnp)-NH2 是 caspase-7 的荧光底物。可用于定量 caspase-7 活性。
T36686	Ac-Arg-Gly-Lys(Ac)-AMC
	Ac-RGK(Ac)-AMC, fluorogenic substrate for assaying histone deacetylase (HDAC) activity in a two-step enzymatic reaction. The assay consists of the initial lysine deacetylation by HDAC followed by the release of the fluorescent group by trypsin.
T36363	Dnp-RPLALWRS (trifluoroacetate salt)
	Dnp-RPLALWRS is a fluorogenic substrate for matrix metalloproteinase-7 (MMP-7). The activity of MMP-7 can be quantified by measuring tryptophan fluorescence that is unquenched upon peptide hydrolysis that removes the N-terminal dinitrophenol (Dnp) group.
T40384	Mca-Ala-Pro-Lys(Dnp)-OH
	Mca-Ala-Pro-Lys(Dnp)-OH, a specific quenched fluorogenic substrate for ACE2, enables the detection of ACE2 activity in various tissues including urinary, heart, and lung.
T75107	CrBKA
	CrBKA 是SIRT6的弱活性荧光小分子底物。
T28405	Phe-Pro-Arg-PABA-Resorufin
	Phe-Pro-Arg-PABA-Resorufin is a Chromogenic and fluorogenic peptide substrate for the highly sensitive detection of proteases in biological matrices. The substrate is also applicable to the sensitive detection of the thrombin inhibitor dabigatran in human
TP2169	Boc-Leu-Gly-Arg-AMC	Others	Others
	Boc-Leu-Gly-Arg-AMC is a fluorogenic AMC substrate of the convertases used in enzymatic assays.
TP1129	Boc-Ile-Glu-Gly-Arg-AMC IEGR-AMC
	Boc-Ile-Glu-Gly-Arg-AMC (IEGR-AMC), a specific, highly fluorogenic substrate for clotting enzyme factor Xa (coagulation factor Xa). Boc-IEGR-AMC is also hydrolyzed by acrosin from the ascidian Halocynthia roretzi.
T80211	Ac-KQL-AMC
	Ac-KQL-AMC是量化蛋白酶体样活性的荧光底物，其被裂解时释放可检测的荧光信号。
T80112	Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 是一种用于检测HIV-1蛋白酶活性的荧光底物。
T35612	CytoCalcein™ Violet 500
	CytoCalcein Violet 500 is a fluorogenic dye used to assess cell viability. It is a cell-permeable dye that, upon entering cells, is cleaved by intracellular esterases. CytoCalcein Violet 500 is retained by living cells and displays excitation/emission maxima of 405/500 nm, respectively.
T37002	7-Fluoro-2,1,3-benzoxadiazole-4-sulfonate (ammonium salt)
	7-Fluoro-2,1,3-benzoxadiazole-4-sulfonate (SBD-F) is a thiol-reactive fluorogenic probe.1It has been used to quantify the levels of homocysteine, cysteine, and cysteamine in human plasma.2SBD-F displays excitation/emission maxima of 380/515 nm, respectively.1 1.Imai, K., Toyo’oka, T., and Watanabe, Y.A novel fluorogenic reagent for thiols: Ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sulfonateAnal. Biochem.128(2)471-473(1983) 2.Ichinose, S., Nakamura, M., Maeda, M., et al.A validated HPLC-fluoresc...
T76606	Ac-Trp-Glu-His-Asp-AMC
	Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) 是caspase-1的有效荧光底物。
T76607	Boc-Arg-Val-Arg-Arg-AMC hydrochloride
	Boc-Arg-Val-Arg-Arg-AMC hydrochloride (Boc-RVRR-AMC) 是一种合成的荧光底物，可被furin 蛋白酶有效裂解。
T40837	7-Acetoxy-1-methylquinolinium iodide 7-乙酰氧基-1-甲基喹啉溴化物,AMQI
	7-Acetoxy-1-methylquinolinium iodide (AMQI) serves as a fluorogenic substrate for cholinesterase, with excitation (Ex) occurring at 320 nm and emission (Em) at 410 nm. In the fluorometric flow system, the hydrolysis of this compound is employed for the detection and identification of inhibitors.
T36354	Suc-YVAD-AMC (acetate)
	Suc-YVAD-AMC is a fluorogenic substrate for caspase-1. Upon enzymatic cleavage by caspase-1, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify caspase-1 activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.
T80545	Ac-VEID-AFC	Caspase	Apoptosis; Proteases/Proteasome
	Ac-VEID-AFC为caspase-6专一的荧光底物，适用于测定caspase 6活性。
T36334	Z-VAD-AMC (acetate)
	Z-VAD-AMC is a fluorogenic substrate for caspase-1. Upon enzymatic cleavage by caspase-1, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify caspase-1 activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.
T38378	Dnp-PLAYWAR (trifluoroacetate salt)
	Dnp-PLAYWAR is a fluorogenic substrate for matrix metalloproteinase-8 (MMP-8) and MMP-26. The activity of MMP-8 and MMP-26 can be quantified by measuring tryptophan fluorescence that is unquenched upon peptide hydrolysis that removes the N-terminal dinitrophenol (Dnp) group.

化合物

hCYP3A4 Fluorogenic substrate 1

Cat.No: T77698

Target: Others

MMP-3 Fluorogenic Substrate TFA

Cat.No: T83759

Synonym: Mca-RPKPVE-Nval-WR-K(Dnp)-NH2,Matrix Metalloproteinase-3 Fluorogenic Substrate,Stromelysin-1 Fluorogenic Substrate

Enteropeptidase Fluorogenic Substrate

Cat.No: T37021

Renin Fluorogenic Substrate

Cat.No: T35880

Enteropeptidase Fluorogenic Substrate (trifluoroacetate salt)

Cat.No: T37022

Z-Ala-Arg-Arg-AMC

Cat.No: T78625

Synonym: Z-ARR-AMC,Fluorogenic Proteasome Substrate

Target: Proteasome

4-Methylumbelliferyl phosphate

Cat.No: T18888

Synonym: 4-甲基伞形酮磷酸酯,4-MUP

Target: Others

Cat.No: TD0081

Synonym: EDANS acid [5-((2-Aminoethyl)amino)naphthalene-1-sulfonic acid],EDANS酸,1,5-EDANS,EDANS acid [5-((2-Aminoethyl)amino)napht

Target: Others

4-Methylumbelliferyl-β-D-Glucopyranoside

Cat.No: T37571

Synonym: MU-GLU,4-MUG,4-MU-GLU,4-MU-β-Gluc,4-甲基伞形酮酰-Β-D-吡喃葡糖酸苷

Target: Others

Cat.No: TP1326

Target: Others

Cat.No: T18912

Synonym: 10-乙酰基-3,7-二羟基吩嗪,10-Acetyl-3,7-dihydroxyphenoxazine

Target: Others

H-β-Ala-AMC TFA

Cat.No: T64341

Target: Others

4-Methylumbelliferyl-β-D-glucuronide hydrate

Cat.No: T18887

Synonym: 4-甲基伞形酮-Β-D-葡糖苷酸二水合物,MUG

Target: Others

Cat.No: T11221

Target: Others

Z-Gly-Gly-Arg-AMC TFA (66216-78-2 free base)

Cat.No: T8556

Synonym: Z-Gly-Gly-Arg-AMC TFA

Target: Others

Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)

Cat.No: T37504L

Synonym: Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)

2',7'-Dichlorofluorescein diacetate

Cat.No: T20684

Synonym: Diacetyldichlorofluorescein,Leuco-dcf diacetate,Dcfh-DA,双氯荧光黄乙酸乙酯,DCFDA

Target: Others

4-Methylumbelliferyl-α-D-Galactopyranoside

Cat.No: T37192

Synonym: 4MU-α-Gal

Target: Others

Cat.No: T33795

Synonym: 3-OMFP

Fluorescein di(β-D-galactopyranoside)

Cat.No: T18993

Synonym: FDG

Target: Others

Cat.No: T19047

Target: Others

Cat.No: T18937

Synonym: 3-Carboxyumbelliferyl-β-D-galactopyranoside

Target: Others

7-Lysylalanyl-4-methylcoumarinamide

Cat.No: T29485

Cat.No: TP1099

Synonym: Methoxycoumarin-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys-dinitrophenyl

HIV Protease Substrate 1

Cat.No: T39729

HKYellow-AM (6/12-mixture)

Cat.No: T38933

Janelia Fluor® 526, SE

Cat.No: T82016

Synonym: JF526, SE,JF526, NHS

Z-Gly-Gly-Arg-AMC

Cat.No: TP1799

Cat.No: TP1368

Tos-Gly-Pro-Lys-AMC

Cat.No: T80107

Cat.No: T80110

Target: Caspase

Mca-VDQVDGW-Lys(Dnp)-NH2

Cat.No: T76268

Ac-Arg-Gly-Lys(Ac)-AMC

Cat.No: T36686

Dnp-RPLALWRS (trifluoroacetate salt)

Cat.No: T36363

Mca-Ala-Pro-Lys(Dnp)-OH

Cat.No: T40384

Cat.No: T75107

Phe-Pro-Arg-PABA-Resorufin

Cat.No: T28405

Boc-Leu-Gly-Arg-AMC

Cat.No: TP2169

Target: Others

Boc-Ile-Glu-Gly-Arg-AMC

Cat.No: TP1129

Synonym: IEGR-AMC

Cat.No: T80211

Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2

Cat.No: T80112

Target: HIV Protease

CytoCalcein™ Violet 500

Cat.No: T35612

7-Fluoro-2,1,3-benzoxadiazole-4-sulfonate (ammonium salt)

Cat.No: T37002

Ac-Trp-Glu-His-Asp-AMC

Cat.No: T76606

Boc-Arg-Val-Arg-Arg-AMC hydrochloride

Cat.No: T76607

7-Acetoxy-1-methylquinolinium iodide

Cat.No: T40837

Synonym: 7-乙酰氧基-1-甲基喹啉溴化物,AMQI

Suc-YVAD-AMC (acetate)

Cat.No: T36354

Cat.No: T80545

Target: Caspase

Z-VAD-AMC (acetate)

Cat.No: T36334

Dnp-PLAYWAR (trifluoroacetate salt)

Cat.No: T38378

Cat. No.	Product Name	Target	Signaling Pathways
T4820	Maleimide 马来酰亚胺,2,5-Pyrroledione	Others	Others
	Maleimide (2,5-Pyrroledione) 可用于制备荧光探针，主要用于硫醇分析物的特异性检测。它也可用于制备用于癌症研究的抗体-药物偶联物 (ADC)。

天然产物

Cat.No: T4820

Synonym: 马来酰亚胺,2,5-Pyrroledione

Target: Others

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