Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9111 |
8-Azaadenosine
|
Adenosine deaminase | Metabolism |
8-Azaadenosine 是 ADAR1抑制剂和是 A-to-I 编辑抑制剂。它可阻断 RNA 编辑并抑制甲状腺癌细胞的增殖、3D 生长、侵袭和迁移。 | |||
T40153 |
BAMEA-O16B
BAMEA-O16B |
||
BAMEAO16B is a lipid nanoparticle that incorporates disulfide bonds for efficient delivery of Cas9 mRNA and sgRNA into cells. In the intracellular environment, BAMEAO16B responds to reduction by releasing RNA, facilitating genome editing. This compound is valuable for gene editing research purposes. | |||
T79763 |
UNC9512
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
UNC9512是一种针对甲基赖氨酸读取器p53结合蛋白1 (53BP1) 的有效拮抗剂, 适用于探究53BP1在DNA修复、基因编辑及肿瘤发生等生物学过程的功能。 | |||
T74879 | 306-N16B | ||
306-N16B 是一种脂质纳米颗粒,可实现 Cas9 mRNA 和 sgRNA 的系统性协同递送。306-N16B 可将 mRNA 转运至肺内皮细胞。306-N16B 可用于基因组编辑疗法的研究。 | |||
T60520 | Cas9-IN-3 | ||
Cas9-IN-3 是一种有效的Cas9抑制剂,IC50值为28 μM。CRISPR/Cas 系统彻底改变了多个物种的基因编辑。 | |||
T38320 |
93-O17S
93-O17S |
||
93-O17S is a chalcogen-containing cationic lipidoid.1It has been used in the synthesis of lipid nanoparticles (LPNs) for the delivery of Cre recombinase and ribonucleoproteins for genome editing in mice. LPNs containing 93-O17S have been used for the intratumoral delivery of cGAMP to enhance cross-presentation of tumor antigens and stimulation of interferon genes (STING) activation in a B16/F10 murine melanoma model.2 1.Li, Y., Yang, T., Yu, Y., et al.Combinatorial library of chalcogen-containin... | |||
T74445 | ZA3-Ep10 | ||
ZA3-Ep10是一种两性离子的脂质,用于合成脂质纳米颗粒,用于体内 RNA 传递和非病毒 CRISPR/Cas 基因编辑。 | |||
T38319 |
93-O17O
93-O17O |
||
93-O17O is a chalcogen-containing cationic lipidoid.1,2It has been used in the generation of lipid nanoparticles (LPNs). LPNs containing 93-O17O localize to the spleen after intravenous injection into mice.1LPNs containing 93-O17O have been used for the delivery of Cre recombinase and ribonucleoproteins for genome editing in mice and for the intratumoral delivery of cGAMP to enhance cross-presentation of tumor antigens.3,2 1.Zhao, X., Chen, J., Qiu, M., et al.Imidazole-based synthetic lipidoids ... | |||
T72764 |
8-Azanebularine
|
||
8-Azanebularine是通过将C6位的氨基替换为氢的化合物,能在高浓度(IC50=15 mM)下抑制ADAR2活性。该化合物在人类ADAR2识别的RNA结构中插入,展示出高亲和力(KD=2 nM)。因此,8-Azanebularine可应用于研究ADAR催化的RNA编辑过程。 |