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Cat. No.	Product Name	Target	Signaling Pathways
T11344	G150	DNA; cGAS	DNA Damage/DNA Repair; Immunology/Inflammation
	G150 是高选择性h-cGAS 抑制剂，IC50值为 10.2 nM，用于抑制 dsDNA 引发的干扰素表达。
T5486	RU.521 RU320521	DNA; cGAS	DNA Damage/DNA Repair; Immunology/Inflammation
	RU.521 (RU3205217) 是选择性的环状 GMP-AMP 合成酶 (cGAS) 抑制剂，抑制 cGAS 介导的干扰素上调。它也抑制dsDNA 激活受体的活性，IC50为 700 nM。它可降低来自 Aicardi-Goutières 综合征小鼠模型的巨噬细胞中干扰素的组成型表达。
T38709	PFM39
	PFM39, a Mirin analog, is a potent and selective inhibitor of MRE11 exonuclease activity, specifically targeting the inhibition of phosphate rotation necessary for double-stranded DNA (dsDNA) exonuclease function. Importantly, PFM39 does not inhibit Thermotoga maritima Mre11 (TmMre11) or human MRE11/MRN complex endonuclease activity.
T83217	Abetimus LJP 394 free base
	Abetimus (LJP 394 free base)为一种由四个双链DNA (dsDNA) 寡核苷酸构成的免疫抑制剂，其作用机制为通过交联B细胞表面的抗dsDNA抗体，从而降低体内抗dsDNA抗体水平，具备作为系统性红斑狼疮研究工具的潜力。
T69663	G108
	G108 is a Novel h-cGAS specific inhibitor for repression of dsDNA-triggered interferon expression (IC50 of 27.5 nM and 5150 nM for h-cGAS and m-cGAS, respectively).
T82995	Antiviral agent 33
	Antiviralagent 33（化合物 1c）作为一种抗双链 DNA (dsDNA) 病毒的抑制剂，针对 VACV 和 AdV5 表现出的IC50值分别是 0.0790 µM 和 0.1572 µM，同时展现了潜在的口服给药能力。
TD0001	SYBR GREEN 1 SUPER Green I （效果同SYBR Green I）核酸染料（10,000× DMSO溶液）（电泳级）,SYBR(R) GREEN I NUCLEIC ACID GEL STAIN *10,000× concentrate in DMSO,SYBRGREENⅠ核苷酸胶体染料	Others	Others
	SYBR GREEN 1 是一种不对称花青染料，用于检测核酸。它由一个 N-烷基化的苯并噻唑或苯并恶唑环系统组成，通过一甲基桥连接到吡啶鎓或喹啉鎓环系统。 SYBR Green I 与 dsDNA 的小沟结合，在 480 nm 波长处被激发。它具有 520 nm 的峰值荧光发射。
T36985	Cyclic di-UMP (sodium salt)
	Cyclic di-UMP is a pyrimidine-containing cyclic dinucleotide (CDN).1It is produced by bacterial cGAS/DncV-like nucleotidyltransferases (CD-NTases), such as LpCdnE02 fromL. pneumophila, and binds to cGAS, in the apo or dsDNA-bound forms, with reduced affinity compared to 2'3'-cGAMP or 3'3'-cGAMP .1,2Cyclic di-UMP is intended for use as a negative control for cyclic di-GMP signaling. 1.Whiteley, A.T., Eaglesham, J.B., de Oliveira Mann, C.C., et al.Bacterial cGAS-like enzymes synthesize diverse nuc...
T37904	Gadoleic Acid
	Gadoleic acid is a monounsaturated fatty acid.1,2It inhibits the dsDNA binding activity of p53 when used at a concentration of 1.2 nM.1Hepatic levels of gadoleic acid are reduced in rats fed a high-fat or a high-fat high-cholesterol diet and increased in rats fed a high-cholesterol diet.2 1.Iijima, H., Kasai, N., Chiku, H., et al.The inhibitory action of long-chain fatty acids on the DNA binding activity of p53Lipids41(6)521-527(2006) 2.Serviddio, G., Bellanti, F., Villani, R., et al.Effects of ...
T81640	NSC15520
	NSC15520是一种小分子RPA抑制剂，特异性结合RPA的N端DNA结合域(DBD)，阻断其与p53或RAD9的相互作用。它还能够抑制双链DNA(dsDNA)寡核苷酸的螺旋不稳定性，影响DNA复制、修复、重组及损伤反应信号。
TD0003L	CelGreen nucleic acid gel stain 10,000× concentrate in DMSO
	CelGreen nucleic acid gel stain 10,000× concentrate in DMSO is a fluorescent dye with a unique involvement that binds to all dsDNA double helix sulcus regions.In the free state, the side strand and CelGreen emit weak fluorescence, but the fluorescence is greatly enhanced once they are combined with the double-stranded DNA. Therefore, the fluorescence signal strength of CelGreen is related to the amount of double-stranded DNA, and the amount of double-stranded DNA in the PCR system can be detec...
T83668	Nucleic Acid Dye Green I NucGel Green I Nucleic Acid Gel Stain,Green I Nucleic Acid Gel Stain
	Nucleic Acid Dye Green I是一种不可渗透细胞的荧光染料，通常用于双链DNA和单链DNA的定量分析。它的激发和发射峰值分别为497 nm和520 nm。Nucleic Acid Dye Green I也被用于基因表达和RT-PCR检测。
T75338	Acridine Orange base
	Acridine Orange base是细胞通透性荧光染料，可使生物体（例如细菌、寄生虫、病毒等）呈现亮橙色，而在特定条件下（pH=3.5，Ex=460 nm）则能使人类细胞显现绿色，便于用荧光显微镜检测。此外，Acridine Orange base与dsDNA结合产生绿色荧光（Ex=488, Em=520-524），与ssDNA（Ex=457, Em= 630-644）或ssRNA结合时则显红色荧光（Ex=457, Em=630-644），适用于细胞周期的测定。
TD0003	CelGreen nucleic acid gel stain 10,000× concentrate in water	Others	Others
	CelGreen 是一种具有独特参与性的荧光染料，可与所有 dsDNA 双螺旋沟区域结合。在游离状态下，侧链和 CelGreen 发出微弱的荧光，但一旦与双链DNA 结合，荧光就会大大增强。因此，CelGreen 的荧光信号强度与双链DNA 的量有关，可以根据荧光信号检测PCR 系统中双链DNA 的量。
TD0002	CelRed nucleic acid gel stain 10,000× concentrate in water
	1) Non-toxicity: The unique oiliness and high molecular weight characteristics of CelRed prevent it from penetrating cell membranes into cells, and Ames test results also show that the mutagenicity of CelRed dye is much less than EB. 2) High sensitivity:

化合物

Cat.No: T11344

Target: DNA, cGAS

Cat.No: T5486

Synonym: RU320521

Target: DNA, cGAS

Cat.No: T38709

Cat.No: T83217

Synonym: LJP 394 free base

Cat.No: T69663

Antiviral agent 33

Cat.No: T82995

Cat.No: TD0001

Synonym: SUPER Green I （效果同SYBR Green I）核酸染料（10,000× DMSO溶液）（电泳级）,SYBR(R) GREEN I NUCLEIC ACID GEL STAIN *10,000× concentrate in DMSO,SYBRGREENⅠ核苷酸胶体染料

Target: Others

Cyclic di-UMP (sodium salt)

Cat.No: T36985

Cat.No: T37904

Cat.No: T81640

CelGreen nucleic acid gel stain *10,000× concentrate in DMSO*

Cat.No: TD0003L

Nucleic Acid Dye Green I

Cat.No: T83668

Synonym: NucGel Green I Nucleic Acid Gel Stain,Green I Nucleic Acid Gel Stain

Acridine Orange base

Cat.No: T75338

CelGreen nucleic acid gel stain *10,000× concentrate in water*

Cat.No: TD0003

Target: Others

CelRed nucleic acid gel stain *10,000× concentrate in water*

Cat.No: TD0002

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