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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T16481	PF-04995274	5-HT Receptor	GPCR/G Protein; Neuroscience
	PF-04995274 是强效，高亲和力，口服活性血清素 4 受体的部分激动剂。它是可脑渗透的，可用于与阿尔茨海默症相关的认知障碍的研究。
T10075	2-Methyl-5-HT 2-Methyl-5-hydroxytryptamine,2-甲基-5-羟基色氨酸盐酸	5-HT Receptor	GPCR/G Protein; Neuroscience
	2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) 是5-HT3受体的选择性激动剂，显示出抗抑郁样作用。
T10075L2	2-Methyl-5-HT hydrochloride 2-Methyl-5-hydroxytryptamine hydrochloride	5-HT Receptor	GPCR/G Protein; Neuroscience
	2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.
T10075L	2-Methyl-5-HT maleate 2-Methylserotonin maleate,2-Methyl-5-hydroxytryptamine maleate,2-Me-HT maleate	5-HT Receptor	GPCR/G Protein; Neuroscience
	2-Methyl-5-HT maleate (2-Methyl-5-hydroxytryptamine maleate) is a potent and selective 5-HT3 receptor agonist, which is shown to display anti-depressive-like effects[1].
T40778	Tyrosylleucine TFA Tyr-Leu TFA
	Tyrosylleucine (Tyr-Leu, YL) TFA is a dipeptide compound with potent antidepressant-like activity. This orally active compound demonstrates effective modulation of depressive symptoms.
T40849	C20 Ceramide N-Arachidoyl-D-sphingosine	Endogenous Metabolite	Metabolism
	C20 Ceramide (N-Arachidoyl-D-sphingosine) 是一种存在于大脑中的 20:0 神经酰胺，可穿越血脑屏障激活小胶质细胞，诱导抑郁样行为。
T71537	Tofenacin hydrochloride
	Tofenacin hydrochloride is an antidepressant drug with a tricyclic-like structure. It acts as a serotonin-norepinephrine reuptake inhibitor, and based on its close relation to orphenadrine, may also possess anticholinergic and antihistamine properties. Tofenacin is also the major active metabolite of orphenadrine and likely plays a role in its beneficial effects against depressive symptoms seen in Parkinson's disease patients.
T79229	ETAP	Monoamine Oxidase	Neuroscience
	ETAP为一种既抑制MAO-A也抑制MAO-B的化合物，展现出抗抑郁样活性，可应用于重度抑郁症的研究领域。
T70487	Tofenacin (free base)
	Tofenacin (free base) is an antidepressant drug with a tricyclic-like structure. It acts as a serotonin-norepinephrine reuptake inhibitor, and based on its close relation to orphenadrine, may also possess anticholinergic and antihistamine properties. Tofenacin is also the major active metabolite of orphenadrine and likely plays a role in its beneficial effects against depressive symptoms seen in Parkinson's disease patients.
T70174	Pirlindole-d4 HCl
	Pirlindole-d4 is intended for use as an internal standard for the quantification of pirlindole by GC- or LC-MS. Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor. It is selective for MAO-A over MAO-B. In rats, it reverses the depressive-like effects induced by chronic mild stress (CMS), increases proliferation of hippocampal neural progenitor cells, and reverses dendritic atrophy in granule neurons. Pirlindole is also an inhibitor of enterovirus-D68 and coxsackieviru...

化合物

PF-04995274

Cat.No: T16481

Synonym:

Target: 5-HT Receptor

2-Methyl-5-HT

Cat.No: T10075

Synonym: 2-Methyl-5-hydroxytryptamine,2-甲基-5-羟基色氨酸盐酸

Target: 5-HT Receptor

2-Methyl-5-HT hydrochloride

Cat.No: T10075L2

Synonym: 2-Methyl-5-hydroxytryptamine hydrochloride

Target: 5-HT Receptor

2-Methyl-5-HT maleate

Cat.No: T10075L

Synonym: 2-Methylserotonin maleate,2-Methyl-5-hydroxytryptamine maleate,2-Me-HT maleate

Target: 5-HT Receptor

Tyrosylleucine TFA

Cat.No: T40778

Synonym: Tyr-Leu TFA

Target:

C20 Ceramide

Cat.No: T40849

Synonym: N-Arachidoyl-D-sphingosine

Target: Endogenous Metabolite

Tofenacin hydrochloride

Target: Monoamine Oxidase

Tofenacin (free base)

Cat. No.	Product Name	Target	Signaling Pathways
T3933	Jatrorrhizine Yatrorizine,neprotin,药根碱	MAO; 5-HT Receptor; Antibacterial; AChE	GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Jatrorrhizine (neprotin) 是一种从黄连中分离得到的生物碱，具有抗菌、抗氧化、抗疟原虫和神经保护活性。它通过抑制 uptake-2 transporter 的活性减少血清素和去甲肾上腺素的摄取。它是一种有口服活性的乙酰胆碱酯酶制剂。
T4912	Jatrorrhizine chloride 盐酸药根碱,Yatrorhizine chloride,Neprotine chloride	Others; 5-HT Receptor; OCT; Antibacterial; AChE	GPCR/G Protein; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Others
	Jatrorrhizine chloride (Neprotine chloride) 是从黄连中分离得到的生物碱，具有神经保护、抗菌、抗氧化和抗疟原虫活性。它通过抑制摄取2转运蛋白的活性减少血清素和去甲肾上腺素的摄取。它是具有口服活性的乙酰胆碱酯酶抑制剂。

天然产物

Jatrorrhizine

Cat.No: T3933

Synonym: Yatrorizine,neprotin,药根碱

Target: MAO, 5-HT Receptor, Antibacterial, AChE

Jatrorrhizine chloride

Cat.No: T4912

Synonym: 盐酸药根碱,Yatrorhizine chloride,Neprotine chloride

Target: Others, 5-HT Receptor, OCT, Antibacterial, AChE

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