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Search Results for " cytoskeletal "

13

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T11394	GFB-8438	TRP/TRPV Channel	Membrane transporter/Ion channel
	GFB-8438 是有效的TRPC5选择性抑制剂，对 hTRPC5 和 hTRPC4 的IC50分别为 0.18 和 0.29 μM。它对 TRPC6、其他 TRP 家族成员、NaV1.5 具有良好的选择性，对 hERG 通道的活性也有限。它对小鼠足细胞的保护作用。
T2011	RKI1313 RKI 1313,RKI-1313	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	RKI1313 (RKI-1313) 是一种选择性抑制剂，可抑制 ROCK 依赖性信号传导、细胞骨架变化、不依赖锚定的集落形成、迁移和侵袭。
T69436	Endosidin7
	Endosidin7 is a specific inhibitor for plant callose deposition during cytokinesis without affectting endomembrane trafficking during interphase or cytoskeletal organization.
T25009	AK 275 AK275,AK-275
	AK 275 is a calpain inhibitor that prevents degradation of cytoskeletal and myelin proteins in spinal cord in vitro.
T68317	VJ115
	VJ115 is a novel chemical entity that inhibits the enzyme ENOX1, a NADH oxidase. Genetic and small molecule inhibition of ENOX1 inhibits endothelial cell tubule formation and tumor-mediated neo-angiogenesis. Inhibition of ENOX1 radiosensitizes tumor vasculature, a consequence of enhanced apoptosis. VJ115 inhibition of ENOX1 can impact expression of proteins involved in cytoskeletal reorganization and support a hypothesis in which ENOX1 activity links elevated cellular NADH concentrations with cy...
T35827	Epsilon-V1-2 PKCε Inhibitor Peptide,Protein Kinase Cɛ Inhibitor Peptide,ɛV1-2
	Protein kinase C (PKC ) is a calcium-independent, phospholipid- and diacylglycerol-dependent serine/threonine kinase involved in diverse signaling pathways, including those involved in neuronal signaling, cytoskeletal function, and inflammation.[1] PKC inhibitor peptide is a synthetic peptide corresponding to an amino acid sequence found in the amino terminal C2 domain of most mammalian forms of PKC .[2] It selectively and reversibly inhibits the translocation of PKC to intracellular membrane...
T63984	PF-3758309 dihydrochloride
	PF-3758309 dihydrochloride 是一种有效的、可逆的、口服具有活力的、 ATP 竞争性的 PAK4 抑制剂，其 Kd 值为 2.7 nM，Ki 值为 18.7 nM。PF-3758309 dihydrochloride 显示出 PAK4 抑制剂的预期细胞功能，能够抑制锚定独立生长、诱导凋亡、细胞骨架重塑和抑制增殖。
T38336	W140 (trifluoroacetate salt) W140 (trifluoroacetate salt)
	Sphingosine-1-phosphate (S1P) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It exerts its activity by binding to five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. W140 is an inactive enantiomer of W146, a selective S1P1 antagonist (Ki = 77 nM), that binds to the S1P1 receptor with a Ki of 4.6 μM (2a = W146; 2b = W...
T37028	PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt) PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt)
	The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin α and the Akt-family of GTPase activating proteins are examples of PtdIns-(3,4,5)-P3-binding proteins. Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal ...
T35459	Glycyl H-1152 hydrochloride
	Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. Glycyl-H-1152 is a selective and potent ROCK inhibitor (IC50 = 11.8 nM for ROCK-II). It is a glycylated isoquinoline compound derived from the therapeutically-important ROCK inhibitor HA-1077 (Fasudil) and exhibits bett...
T83661	17(R,S)-Benzo-Resolvin D1 17(R,S)-Benzo-RvD1,Benzo-RvD1
	17(R,S)-Benzo-resolvin D1 (benzo-RvD1) 是专门的分辨介质 (SPM) RvD1 的衍生物。在10和100 nM的浓度下，它能减少PDGF-BB诱导的人类血管平滑肌细胞 (VSMCs) 的细胞骨架变化，并抑制PDGF诱导的这些细胞的迁移。Benzo-RvD1 (10 nM) 抑制人脐静脉内皮细胞 (HUVECs) 中的p65核转位。它还提高了RAW 264.7对S. aureus和zymosan颗粒的吞噬作用。
T35491	3,5-dimethyl PIT-1
	PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. Protein binding to PIP3 is important for cytoskeletal rearrangement and membrane trafficking and initiates an intricate signaling cascade that has been implicated in cancer. 3,5-dimethyl PIT-1 is a dimethyl analog of PIT-1, the selective inhibitor of PIP3/Akt PH domain binding, that is designed for more favorab...
T36939	PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt) PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)
	The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3, also known as PIP3, is resistant to cleavage by PI-specific phospholipase C (PLC). Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. PIP3 can serve as an anchor for the binding of signal transd...

化合物

Cat.No: T11394

Target: TRP/TRPV Channel

Cat.No: T2011

Synonym: RKI 1313,RKI-1313

Target: ROCK

Cat.No: T69436

Cat.No: T25009

Synonym: AK275,AK-275

Cat.No: T68317

Cat.No: T35827

Synonym: PKCε Inhibitor Peptide,Protein Kinase Cɛ Inhibitor Peptide,ɛV1-2

PF-3758309 dihydrochloride

Cat.No: T63984

W140 (trifluoroacetate salt)

Cat.No: T38336

Synonym: W140 (trifluoroacetate salt)

PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt)

Cat.No: T37028

Synonym: PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt)

Glycyl H-1152 hydrochloride

Cat.No: T35459

17(R,S)-Benzo-Resolvin D1

Cat.No: T83661

Synonym: 17(R,S)-Benzo-RvD1,Benzo-RvD1

3,5-dimethyl PIT-1

Cat.No: T35491

PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)

Cat.No: T36939

Synonym: PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)

Cat. No.	Product Name	Target	Signaling Pathways
T3864	Erianin	BCL; Antibacterial	Apoptosis; Microbiology/Virology
	Erianin 能抑制吲哚胺-2,3-双加氧酶诱导的肿瘤血管生成，可用作退烧药和止疼剂。

天然产物

Cat.No: T3864

Target: BCL, Antibacterial

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