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Search Results for " cyclic dinucleotide "

12

抑制剂 & 化合物

1

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Cat. No.	Product Name	Target	Signaling Pathways
T9137	SN-011 [1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-,GUN35901	STING	Immunology/Inflammation
	SN-011 (GUN35901) 是选择性 STING 抑制剂，可与环状二核苷酸 (CDN) 竞争 STING 二聚体的结合口袋，从而阻断 CDN 结合和 STING 激活。它用于 STING 驱动的自身免疫和炎症性疾病的研究，抑制 STING 信号传导的 IC50值为 76 nM。
T11596	IACS-8803	Others	Others
	IACS-8803 is a potent cyclic dinucleotide STING agonist that exhibits strong systemic antitumor efficacy.
T73939	IACS-8803 diammonium
	IACS-8803 diammonium 是一种高效环状二核苷酸的STING 激动剂，具有强大的全身抗肿瘤作用。
T73938	IACS-8803 disodium
	IACS-8803 disodium 是一种高效环状二核苷酸的STING 激动剂，具有强大的全身抗肿瘤作用。
T74727	CL845-PAB-Ala-Val-C5-MC
	CL845-PAB-Ala-Val-C5-MC 是一种可结合的 STING 配体，由专有的环状二核苷酸 CL845 合成。CL845-PAB-Ala-Val-C5-MC 可用于生物偶联。
T36985	Cyclic di-UMP (sodium salt)
	Cyclic di-UMP is a pyrimidine-containing cyclic dinucleotide (CDN).1It is produced by bacterial cGAS/DncV-like nucleotidyltransferases (CD-NTases), such as LpCdnE02 fromL. pneumophila, and binds to cGAS, in the apo or dsDNA-bound forms, with reduced affinity compared to 2'3'-cGAMP or 3'3'-cGAMP .1,2Cyclic di-UMP is intended for use as a negative control for cyclic di-GMP signaling. 1.Whiteley, A.T., Eaglesham, J.B., de Oliveira Mann, C.C., et al.Bacterial cGAS-like enzymes synthesize diverse nuc...
T39829	BPK-25
	BPK-25 is an active acrylamide compound that enhances the degradation of proteins in the nucleosome remodeling and deacetylation (NuRD) complex through a post-translational mechanism involving covalent protein interaction. Additionally, BPK-25 acts as an inhibitor of TMEM173 activation by the cyclic dinucleotide ligand cGAMP.
T36996	MSA-2 dimer
	MSA-2 dimer is a selective, orally active non-nucleotide STING agonist (Kd=145 μM) with long-term antitumor and immunogenic activity. MSA-2 dimer is bound to STING as a non-covalent dimer exhibiting higher permeability than cyclic dinucleotide[1]. MSA-2 dimer (60 mg/kg; p.o.; 50 days) inhibits tumor growth and prolongs overall survival[1]. MSA-2 dimer (40 mg/kg; s.c.; 25 days) induces complete tumor regression[1].MSA-2 dimer (60 mg/kg; p.o.; 4 hours) increases proinflammatory cytokine (IFN-β) le...
T38091	3'3'-cGAMP (sodium salt)
	3'3'-cGAMP is a second messenger produced in bacteria by specific dinucleotide cyclases. It contains canonical 3'5'-phosphodiester bonds and regulates chemotaxis, colonization, and other cellular functions. 3'3'-cGAMP shows weaker binding to the adapter protein stimulator of interferon genes (STING; Kd = 1.04 μM) than 2'2'-cGAMP and 2'3'-cGAMP but has similar binding affinity to 3'2'-cGAMP (Kd = 1.61 μM) and cyclic di-GMP . 3'3'-cGAMP induces IFN-β mRNA expression in L929 cells (EC50 = 40.5 nM).
T35654	2'2'-cGAMP (sodium salt)
	2'2'-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds. It binds to the adapter protein stimulator of interferon genes , which is a component of the innate immune response that activates the type I interferon pathway when bound to cyclic dinucleotides. 2'2-cGAMP shows weaker binding to STING than 2'3'-cGAMP but binds more strongly than 3'3'-cGAMP , cyclic di-GMP , or 3'2'-cGAMP, which bind in the micromolar range (Kds = 1.04, 1.21, or 1.61 μM, respecti...
T77253	β-Nicotinamide adenine dinucleotide reduced dipotassium
	β-Nicotinamide adenine dinucleotide reduced dipotassium 作为一种口服有效的还原型辅酶，在ADP-核糖基转移酶反应中担任ADP-核糖单元的供体及环状ADP-核糖的前体。该化合物在细胞能量代谢，包含糖酵解、β-氧化及三羧酸(TCA)循环中，发挥重要的再生电子供体角色。
T79313	BI 7446	STING	Immunology/Inflammation
	BI 7446 是一种基于环状二核苷酸 (CDN) 的高效、特异性STING (干扰素基因刺激蛋白) 激动剂。它能激活所有五种STING变体并在体外诱导肿瘤特异性的免疫介导反应，从而消除肿瘤。此化合物适用于免疫肿瘤学领域的研究。

化合物

Cat.No: T9137

Synonym: [1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-,GUN35901

Target: STING

Cat.No: T11596

Target: Others

IACS-8803 diammonium

Cat.No: T73939

IACS-8803 disodium

Cat.No: T73938

CL845-PAB-Ala-Val-C5-MC

Cat.No: T74727

Cyclic di-UMP (sodium salt)

Cat.No: T36985

Cat.No: T39829

Cat.No: T36996

3'3'-cGAMP (sodium salt)

Cat.No: T38091

2'2'-cGAMP (sodium salt)

Cat.No: T35654

β-Nicotinamide adenine dinucleotide reduced dipotassium

Cat.No: T77253

Cat.No: T79313

Target: STING

Cat. No.	Product Name	Target	Signaling Pathways
T13606L	cGAMP disodium
	cGAMP disodium 是在细菌中发现的一种环二核苷酸 (CDN) ，可作为内源性第二信使，影响干扰素的产生以响应胞浆 DNA。cGAMP disodium 通过激活干扰素基因刺激因子 (STING)使 I 型干扰素和其他免疫介质的信号产生级联现象。cGAMP disodium 是一种有效的舌下免疫佐剂，能使免疫功能（血清抗 PA 中和和气道分泌物抗 PA SIgA 反应）更好的发挥作用。

天然产物

Cat.No: T13606L

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