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17

抑制剂 & 化合物

1

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Cat. No.	Product Name	Target	Signaling Pathways
T61009	Complex III-IN-1
	Complex III-IN-1 (Compd 4c-2) 是 complex III 的抑制剂，具有抗真菌活性。Complex III-IN-1 对核盘菌的EC50值为 18.53 mg/L。
T60949	Complex III-IN-2
	Complex III-IN-2 (Compd 4d-2) 是complex III 的抑制剂，具有抗真菌活性，其对植物病菌立枯病菌和核盘菌的EC50值分别为29.31 mg/L 和 29.98 mg/L。
T9491	Pyraclostrobin	Antibacterial; Antifungal	Microbiology/Virology
	Pyraclostrobin 是一种球果苷杀菌剂，可诱导 3T3-L1 细胞内甘油三酯的积累，还可抑制真菌和哺乳动物细胞的线粒体复合物 III 。
T38164	MnTBAP chloride Mn(III)TBAP
	MnTBAP chloride (Mn(III)TBAP) 是一种具有细胞渗透性的超氧化物歧化酶 (SOD) 模拟物和过氧亚硝酸盐清除剂，能使SOD-大肠杆菌的加倍时间减少了2倍。 MnTBAP chloride 通过上调 BMPR-II 和抑制 NFκB 信号传导展现抗炎作用。MnTBAP chloride 是一种锰卟啉配合物，具有抗氧化性能，具有用于研究慢性肾脏疾病 (CKDs) 纤维化反应的潜力。
T68002	Naroparcil	Thrombin	Proteases/Proteasome
	Naroparcil 是一种可口服的硫代苷类化合物，是一种 4-甲基伞形 β-D-木糖苷类似物，在静脉血栓形成（颈静脉）的Wessler淤滞模型中显示出抗血栓形成作用。Naroparcil 增强了凝血酶/肝素辅因子II复合物的形成，诱导了处理兔血浆中硫酸皮肤素样物质的出现，但减少了与（125I）-人α-凝血酶孵育的血浆中的凝血酶/抗凝血酶III复合物的形成。
T27444	GSK 932121 GSK-932121,GSK932121
	GSK 932121 is a potent antimalarial agent. GSK 932121 inhibits selectively the electron-transport chain in P. falciparum at the cytochrome bc1 level (complex III).
T68508	Ametoctradin
	Ametoctradin is a new Oomycete-specific fungicide and a potent Qo site inhibitor of the mitochondrial respiration complex III.
T37498	Antimycin A4
	Antimycin A4 is an active component of the antimycin A antibiotic complex that is more polar than antimycin A1 , antimycin A2 , and antimycin A3 . Antimycin A4 inhibits ATP-citrate lyase with a Ki value of 64.8 μM. The antimycin A complex is a mixture of antimycins A1, A2, A3, and A4 that demonstrates antifungal, insecticidal, nematocidal, and piscicidal properties. It blocks mitochondrial respiration and can deplete cellular levels of ATP via inhibition of complex III of the mitochondrial elect...
TP1504	Urocortin III, mouse TFA (357952-10-4 free base) Urocortin III, mouse TFA
	Urocortin III, mouse TFA is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2. Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in th
T61869	Metyltetraprole
	Metyltetraprole is a potent fungicide that demonstrates promising efficacy against sensitive wild-type and G143A mutant strains of Zymoseptoria tritici, as indicated by its low EC50 values of 0.002 ppm. Additionally, this compound exhibits effectiveness against QoI-resistant strains. Metyltetraprole functions by inhibiting the respiratory chain through complex III [1] [2].
T76025	Urocortin III, mouse TFA
	Urocortin III, mouse TFA是CRF（促肾上腺皮质激素释放因子）相关的肽。该化合物主要通过结合并激活CRF-R2发挥作用。Urocortin III（Ucn3）是已知参与调节行为压力反应体系的组分之一。它和CRF-R2在大脑杏仁核中共同作用，从而参与调控复杂的社会动力学行为。
T74681	NecroIr2
	NecroIr2 是一种铱 (III) 复合物，是顺铂 (Cisplatin) 耐药肺癌细胞 (A549R) 的坏死诱导剂。NecroIr2 选择性积累在线粒体中，导致氧化应激和线粒体膜电位 (MMP) 的损失。NecroIr2 能够激活受体相互作用的丝氨酸苏氨酸激酶 3 (RIPK3) 和混合谱系激酶结构域样假激酶 (MLKL)，调节CDK4表达。
T74680	NecroIr1
	NecroIr1 是一种铱 (III) 复合物，是顺铂 (Cisplatin) 耐药肺癌细胞 (A549R) 的坏死诱导剂。NecroIr1 选择性积累在线粒体中，导致氧化应激和线粒体膜电位 (MMP) 的损失。NecroIr1 能够激活受体相互作用的丝氨酸苏氨酸激酶 3 (RIPK3) 和混合谱系激酶结构域样假激酶 (MLKL)，调节CDK4表达。
T79743	Caspase-3 activator 1	Pyroptosis	Apoptosis; Immunology/Inflammation
	Caspase-3 activator 1 (compound 4b) 是一种Ru(III)金属复合物，它能够有效抑制胃肿瘤细胞的生长与转移。该化合物通过介导caspase-3的活化而促进GSDME的裂解，产生GSDME-N末端，导致胃肿瘤细胞发生膜穿孔。Caspase-3 activator 1还能诱导焦亡及其引发的免疫应答，并可与地西他滨（DCT）构建成4b-DCT-Lip脂质纳米粒子，用于高效药物递送。
T83865	HP661
	HP661是一种针对线粒体复合物I（也称为NADH脱氢酶）的抑制剂，对复合物I具有选择性，以1 µM的浓度抑制其77.6%，而对复合物III抑制率为28.1%，对复合物II和IV则无抑制作用。HP661特异性降低具有高水平氧化磷酸化作用的人类肺癌细胞H460、NCI H441及对trametinib耐药的A549细胞的生存能力（IC50分别为10.6、29.7和15.1 nM），相较于氧化磷酸化水平低的NCI H358人类肺癌细胞（IC50 >10,000 nM）以及非癌性人类胰腺正常上皮细胞（HPNE）和MRC-5人类胎肺成纤维细胞（两者的IC50均>10,000 nM）。当以每天两次，每次30 mg/kg的剂量给药时，HP661在H460小鼠异种移植模型中减少肿瘤体积，并对trametinib引导的肿瘤生长减少产生加成效应。
T37851	Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)
	Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) is an inducer of ferroptosis.1 It induces ferroptosis, but not apoptosis or necroptosis, in NB1 cancer cells when used at a concentration of 3 μM.1 Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) inhibits proliferation of BJAB, NALM-6, Jurkat, MelHO, and MCF-7 cancer cells (IC50s = 0.07, 2.5, 1.5, 3, and 5 μM, respectively), as well as NALM-6 cells resistant to daunorubicin and vincristine when used at concentrations ranging...
T35687	Collismycin A
	Collismycin A is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities, including antibacterial, antiproliferative, and neuroprotective properties. It is active against a variety of bacteria (MICs = 6.25 and 100 μg/ml) and fungi (MICs = 12.5-100 μg/ml). It inhibits proliferation of A549 lung, HCT116 colon, and HeLa cervical cancer cells (IC50s = 0.3, 0.6, and 0.3 μM, respectively) and NIH373 fibroblasts (IC50 = 56.6 μM) but not MDA-MD-231 breast canc...

化合物

Complex III-IN-1

Cat.No: T61009

Complex III-IN-2

Cat.No: T60949

Cat.No: T9491

Target: Antibacterial, Antifungal

MnTBAP chloride

Cat.No: T38164

Synonym: Mn(III)TBAP

Cat.No: T68002

Target: Thrombin

Cat.No: T27444

Synonym: GSK-932121,GSK932121

Cat.No: T68508

Cat.No: T37498

Urocortin III, mouse TFA (357952-10-4 free base)

Cat.No: TP1504

Synonym: Urocortin III, mouse TFA

Metyltetraprole

Cat.No: T61869

Urocortin III, mouse TFA

Cat.No: T76025

Cat.No: T74681

Cat.No: T74680

Caspase-3 activator 1

Cat.No: T79743

Target: Pyroptosis

Cat.No: T83865

Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)

Cat.No: T37851

Cat.No: T35687

Cat. No.	Product Name	Target	Signaling Pathways
T8433	HQNO	Mitochondrial Metabolism	Metabolism
	HQNO 是一种电子传递链抑制剂，对 complex III 的Kd 值为 64 nM，由P. aeruginosa 产生的。它是许多物种的线粒体NDH-2的有效抑制剂。

天然产物

Cat.No: T8433

Target: Mitochondrial Metabolism

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