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33

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1125	Insulin(cattle) 牛胰岛素,Insulin from bovine pancreas,胰岛素	IGF-1R	Tyrosine Kinase/Adaptors
	Insulin cattle (Insulin from bovine pancreas) 是一种在胰腺 β 细胞中产生的两链多肽激素，在很多哺乳动物细胞培养体系中用作生长因子。
T76423	Neuropeptide AF (cattle)
	Neuropeptide AF (cattle)是一种RFamide家族的酰胺化十八肽，主要作用于Mas相关基因受体A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR))和MrgprC11，其EC50分别约为60 nM和300 nM。此外，该化合物还能激活G蛋白偶联受体NPFF1 (Neuropeptide Y Receptor) 和NPFF2，EC50范围分别为25-325 nM和1-5 nM。Neuropeptide AF (cattle)具有显著的抗阿片及疼痛调节功能。
T83102	Antiarrhythmic peptide (cattle atrium)
	Antiarrhythmic peptide (cattle atrium)是一种具有保护作用的六肽，能对抗活性分子诱导的心律不齐。
T76495	16-38-Thymosin β4 (cattle)
	16-38-Thymosin β4 (cattle) 是一种具有高亲和力的非 Ca2+依赖性MLCK 激活剂。
T80088	16-38-Thymosin β4 (cattle) (TFA)	Myosin	Cytoskeletal Signaling
	16-38-Thymosin β4 (cattle) TFA 是高亲和力非 Ca2+依赖性MLCK激活剂。
T20137	Dimethoate Rogor,Phosphamid,Lurgo,L395,乐果,L 395,L-395	Others	Others
	Dimethoate (L-395) 是一种系统性和接触性杀虫剂，用于控制牛蛴螬和农场动物的某些其他害虫。
T4267	Tulathromycin A CP 472295,Draxxin,Tulathromycin,托拉菌素 A	Antibacterial; Antibiotic	Microbiology/Virology
	Tulathromycin A (CP 472295) 是一种大环内酯类抗生素，靶向细菌核糖体抑制蛋白质合成 (IC50=0.26 µM)，具有免疫调节作用。它可研究牛和猪的呼吸道疾病。
T14953	Chloroquinoxaline sulfonamide NSC-339004,Chloroquinoxaline	Topoisomerase	DNA Damage/DNA Repair
	Chloroquinoxaline sulfonamide is a topoisomerase II alpha/beta poison. It is used to control coccidiosis in poultry, rabbit, sheep, and cattle.
T3361	Cambendazole 坎苯达唑,Bonlam,MK-905,Novazole	Others	Others
	Cambendazole (Novazole) 是治疗人类圆线虫病最有效的一种药物。
T15272	Febantel	Parasite	Microbiology/Virology
	Febantel 是一种用于家禽和家畜的蛔虫、绦虫感染的驱虫剂。
T22439	Tilmicosin phosphate 磷酸替米考星,替米考星磷酸盐	Antibacterial; Antibiotic	Microbiology/Virology
	Tilmicosin phosphate 是一种抗生素，可研究曼氏杆菌和巴氏杆菌相关的牛羊呼吸系统疾病。
T16952	Sulfabrom Sulfabromomethazine,N 3517	Anti-infection; Antibacterial	Microbiology/Virology
	Sulfabrom (Sulfabromomethazine) 是一种长效长效磺酰胺药物，用于家禽，猪和牛中的球虫病和各种细菌感染的研究。
T22415	Resorantel	Parasite	Microbiology/Virology
	Resorantel 是一种驱虫剂，用于研究牛和羊的寄生虫病，也被用于研究G. aegypticus。
T37514	Hydroxy Dimetridazole	Drug Metabolite	Metabolism
	Hydroxy Dimetridazole 是Dimetridazol 的羟基化代谢产物。Dimetridazol 是一种硝基咪唑类药物，可用于对抗原生动物感染。
T20590	Zilpaterol hydrochloride
	Zilpaterol hydrochloride is a agonist of β-adrenergic receptor (AR). It is used to increase the feeding efficiency and the size of cattle.
T20772	Crufomate Ruelene,M 1261,M1261,Crufomatum,M-1261
	Crufomate, an insecticide, is used extensively for the control of hornflies, cattle grubs and cattle lice.
T34781	Tameridone R 51 163,R 51163
	Tameridone is a sedative used for cattle.
T20869	Flunixin Sch14714,Flunixinum,Flunixine,Sch 14714,Flunixino,Sch-14714
	Flunixin is a nonsteroidal anti-inflammatory drug (NSAID), antipyretic, and analgesic used in pigs, horses, and cattle.
T20818	Propetamphos Deadmag,Safrotin S 200
	Propetamphos, an organophosphate pesticide, can effectively control cockroaches, flies, mosquitoes, and other pests. It is also effective for cattle lice.
T37849	Butafosfan
	Butafosfan is an organic phosphorus supplement that is given, most commonly with cyanocobalamin, to cattle, swine, horses, and poultry for the prevention or treatment of deficiencies. When given with cyanocobalamin, butafosfan alters lipid metabolism, serving to decrease the prevalence of subclinical ketosis.
T21539	Zilpaterol
	Zilpaterol 是一种有作用的ß-激动剂，可以使牛的脂肪减少和肌肉增加。
TP2378	Diamfenetide NSC-291838,NSC291838,NSC 291838
	Diamfenetide is used in sheep and cattle for the treatment of liver fluxobacteria infections.
T40573	Hydroxymetronidazole Hydroxymetronidazole,Metronidazole-OH
	Hydroxymetronidazole (Metronidazole-OH) is a nitroimidazole compound that functions as a metabolite of Metronidazole. It is commonly employed in poultry research to investigate bacterial and protozoal diseases, as well as in the study of swine dysentery and genital trichomoniasis in cattle.
T19697	Norgestomet SC21009,Norprogesterone, Syncro-Mate B,SC-21009,SC 21009
	Norgestomet is a steroidal progestin of the 19-norprogesterone group used in veterinary medicine to control estrus and ovulation in cattle. In addition to the progesterone receptor, norgestomet possesses a weak (micromolar) affinity for the glucocorticoid
T2214	Flumethrin	Others	Others
	Flumethrin 是一种拟除虫菊酯类杀虫剂。外用在兽药中，用于防治牛、绵羊、山羊、马和狗身上的寄生虫和蜱，以及治疗蜜蜂群中的寄生虫。
T35808	C18:1 Ceramide (d18:1/18:1(9Z)) Cer(d18:1/18:1(9Z))
	C18:1 Ceramide is a naturally occurring ceramide.[1][2][3] Levels of C18:1 ceramide are elevated in overweight and insulin-resistant mice and cattle.[1][2] C18:1 Ceramide is also increased in the plasma and ovarian tissue of patients with advanced ovarian cancer. [3]
T37255	12-methyl Myristic Acid methyl ester
	12-methyl Myristic acid methyl ester is a methylated fatty acid methyl ester that has been found in vermicomposts of cattle manure, carica papaya leaves, and cuticular wax of K. africana. It is a volatile compound in lipid-lowering granulated tea. Levels of 12-methyl myristic acid methyl ester are decreased in T. cruzi treated with nifurtimox compared to non-treated controls.
T35804	C16 Lactosylceramide (d18:1/16:0)
	C16 Lactosylceramide is an endogenous bioactive sphingolipid. It forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors (GPCRs), suggesting a role in cell signaling. Plasma levels of C16 lactosylceramide are elevated in insulin-resistant cattle. C16 Lactosylceramide is also upregulated in a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder.
T37230	(+)-5-trans Cloprostenol
	Cloprostenol is a synthetic derivative of prostaglandin F2α that is used in veterinary medicine as a luteolytic agent for the induction of estrus and in the treatment of reproductive disorders in cattle, swine, and horses. (+)-5-trans Cloprostenol is a minor impurity produced in the synthesis of (+)-cloprostenol. The (+)-5-trans isomer is 20-fold less active than the 5-cis form in terminating pregnancy in the hamster.
T69306	Lubabegron fumarate
	Lubabegron, also known as LY591281; LY488756 fumarate, is a veterinary drug used to reduce ammonia emissions from animals and their waste. Ammonia emissions are a concern in agricultural production because of detrimental effects on the environment, human health, and animal health. Lubabegron was approved by the U.S. Food and Drug Administration in 2018 for use in feedlot cattle. Lubabegron is a beta-adrenergic receptor agonist that has the effect of increasing the breakdown of fats and increasin...
T37231	(+)-Cloprostenol methyl ester
	(+)-Cloprostenol is a synthetic analog of prostaglandin F2α (PGF2α). It is an FP receptor agonist and a potent luteolytic agent in rats and hamsters. It is 200 times and 100 times more potent than PGF2α in terminating pregnancy in hamsters and rats, respectively, without the side effects associated with PGF2α. Cloprostenol is also used in veterinary medicine as a luteolytic agent for the induction of estrus and the treatment of reproductive disorders in cattle, swine, and horses. (+)-Cloprosteno...
T66029	3,4-Dehydro-L-proline
	The leguminous shrub,Leucaena leucocephala(Leucaena) is wide‐spread in tropical and subtropical agricultural systems and provides a ready source of protein for livestock. However, the presence of mimosine, a non‐protein, amino acid comprising about 12% of the dry matter in growing tips ofLeucaena, is toxic to animals. Mimosine is degraded rapidly in the rumen to produce 3,4‐dihydroxypyridine (3,4‐DHP) and 2,3‐dihydroxypyridine (2,3‐DHP), both of which remain toxic to animals[1]. 3,4-DHP, as a de...
T71055	Albendazole-d7
	Albendazole-d7 is intended for use as an internal standard for the quantification of albendazole by GC- or LC-MS. Albendazole is an orally bioavailable benzimidazole anthelmintic that is active against a variety of helminths, including liver flukes, tapeworms, and roundworms. It eliminates Trichostrongylus in the fourth stomach of cattle and sheep when orally administered at doses ranging from 2.5 to 10 mg/kg as well as other species in the fourth stomach and the small and large intestine. Alben...

化合物

Insulin(cattle)

Cat.No: TP1125

Synonym: 牛胰岛素,Insulin from bovine pancreas,胰岛素

Target: IGF-1R

Neuropeptide AF (cattle)

Cat.No: T76423

Antiarrhythmic peptide (cattle atrium)

Cat.No: T83102

16-38-Thymosin β4 (cattle)

Cat.No: T76495

16-38-Thymosin β4 (cattle) (TFA)

Cat.No: T80088

Target: Myosin

Cat.No: T20137

Synonym: Rogor,Phosphamid,Lurgo,L395,乐果,L 395,L-395

Target: Others

Tulathromycin A

Cat.No: T4267

Synonym: CP 472295,Draxxin,Tulathromycin,托拉菌素 A

Target: Antibacterial, Antibiotic

Chloroquinoxaline sulfonamide

Cat.No: T14953

Synonym: NSC-339004,Chloroquinoxaline

Target: Topoisomerase

Cat.No: T3361

Synonym: 坎苯达唑,Bonlam,MK-905,Novazole

Target: Others

Cat.No: T15272

Target: Parasite

Tilmicosin phosphate

Cat.No: T22439

Synonym: 磷酸替米考星,替米考星磷酸盐

Target: Antibacterial, Antibiotic

Cat.No: T16952

Synonym: Sulfabromomethazine,N 3517

Target: Anti-infection, Antibacterial

Cat.No: T22415

Target: Parasite

Hydroxy Dimetridazole

Cat.No: T37514

Target: Drug Metabolite

Zilpaterol hydrochloride

Cat.No: T20590

Cat.No: T20772

Synonym: Ruelene,M 1261,M1261,Crufomatum,M-1261

Cat.No: T34781

Synonym: R 51 163,R 51163

Cat.No: T20869

Synonym: Sch14714,Flunixinum,Flunixine,Sch 14714,Flunixino,Sch-14714

Cat.No: T20818

Synonym: Deadmag,Safrotin S 200

Cat.No: T37849

Cat.No: T21539

Cat.No: TP2378

Synonym: NSC-291838,NSC291838,NSC 291838

Hydroxymetronidazole

Cat.No: T40573

Synonym: Hydroxymetronidazole,Metronidazole-OH

Cat.No: T19697

Synonym: SC21009,Norprogesterone, Syncro-Mate B,SC-21009,SC 21009

Cat.No: T2214

Target: Others

C18:1 Ceramide (d18:1/18:1(9Z))

Cat.No: T35808

Synonym: Cer(d18:1/18:1(9Z))

12-methyl Myristic Acid methyl ester

Cat.No: T37255

C16 Lactosylceramide (d18:1/16:0)

Cat.No: T35804

(+)-5-trans Cloprostenol

Cat.No: T37230

Lubabegron fumarate

Cat.No: T69306

(+)-Cloprostenol methyl ester

Cat.No: T37231

3,4-Dehydro-L-proline

Cat.No: T66029

Cat.No: T71055

Cat. No.	Product Name	Target	Signaling Pathways
T22293	Chondroitine sulfate Chondroitine sulfate (From cattle)	Others	Others
	Chondroitine sulfate 是软骨的重要结构成分，已被用作治疗关节不适的膳食补充剂。
T1157	Moxidectin milbemycin B,CL301423,莫昔克丁,莫西菌素	GluCls; Antibiotic; Parasite	Microbiology/Virology
	Moxidectin (CL301423) 是可用于预防和控制心丝虫和蛔虫的一种驱虫剂。
TMO2681	Xanthosine 9-Beta-D-Ribofuranosylxanthine,黄嘌呤核苷,Xanthine riboside	Others; Endogenous Metabolite	Metabolism; Others
	Xanthosine (9-Beta-D-Ribofuranosylxanthine) 是黄嘌呤核苷，它能够提高山羊和牛的乳腺干细胞数量和产奶量。
T5625	Zearalenone 玉米,Mycotoxin F2,玉米烯酮,RAL,F2 toxin,Toxin F2	Others	Others
	Zearalenone (F2 toxin) 是真菌毒素，主要由食物和饲料中的 Fusarium 产生。它会引起幼龄母猪乳房发育早熟或其它雌激素效应。它在猪、牛、羊体内具有雌激素活性，急性毒性低。

天然产物

Chondroitine sulfate

Cat.No: T22293

Synonym: Chondroitine sulfate (From cattle)

Target: Others

Cat.No: T1157

Synonym: milbemycin B,CL301423,莫昔克丁,莫西菌素

Target: GluCls, Antibiotic, Parasite

Cat.No: TMO2681

Synonym: 9-Beta-D-Ribofuranosylxanthine,黄嘌呤核苷,Xanthine riboside

Target: Others, Endogenous Metabolite

Cat.No: T5625

Synonym: 玉米,Mycotoxin F2,玉米烯酮,RAL,F2 toxin,Toxin F2

Target: Others

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