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Search Results for " catalase "

13

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T40612	Manganese(salen) chloride EUK-8	Others	Others
	Manganese(salen) chloride (EUK-8) 是超氧化物歧化酶和过氧化氢酶的一种模拟物，具有氧自由基清除性能。它可减轻内毒素血症猪的急性肺损伤。
T6495	EUK-134 EUK 134,乙基双亚氨基甲基愈创木酚锰氯化物	Beta Amyloid	Neuroscience
	EUK-134 是合成的超氧化物歧化酶和过氧化氢酶模拟物，可保护大鼠肾脏免受缺血再灌注引起的损伤。它作用于 H9C2 细胞，降低NF-κB 表达、MDA 水平和蛋白质羰基化。它是具有过氧化氢酶活性的超氧化物歧化酶 (SOD) 模拟物 (SODm)。它是保护有丝分裂的抗氧化剂。
T9734	InhA-IN-2	CDK	Cell Cycle/Checkpoint
	InhA-IN-2直接抑制 InhA，不需要过氧化氢酶过氧化物酶 KatG 的激活。
T1374	2-Pyridinecarbohydrazide 2-吡啶甲酰肼,2-Picolinyl hydrazide	Dehydrogenase; CAT	Metabolism; oxidation-reduction
	2-Pyridinecarbohydrazide (2-Picolinyl hydrazide) 是 Catalase-peroxidase-NAPDH 的有效抑制剂。它普遍用于各种合成领域的砌块。
T68342	BTA-EG6
	BTA-EG6 is a novel catalase-amyloid interaction inhibitor, penetrating the blood-brain barrier and protecting cells from Aβ-induced toxicity.
T81120	SP4f	PPAR	DNA Damage/DNA Repair; Metabolism
	SP4f为PPAR-γ激活剂，其在HK-2细胞中EC50值为826 nM。在瑞士白化病小鼠中，SP4f能够降低血糖和脂质过氧化水平，同时提升谷胱甘肽含量和过氧化氢酶活性。
T69365	HMS607P03
	HMS607P03 is an activator of SIRT1 which induces autophagic cell death via the AMPK-mTOR-ULK complex and induces mitophagy by the SIRT1-PINK1-Parkin pathway. HMS607P03 downregulates 14-3-3γ, catalase, profilin-1, and HSP90α.
T78517	Dapsone hydroxylamine DDS-NOH	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Dapsone hydroxylamine (DDS-NOH) 诱导高铁血红蛋白血症，同时抑制过氧化氢酶 (CAT) 活性及活性氧生成，且展现出抗炎活性。
T37613	Ibuprofen Carboxylic Acid
	Ibuprofen carboxylic acid is a major metabolite of ibuprofen . It prevents fructose-, cyanate-, and prednisolone-induced inactivation of catalase and fructose- and cyanate-induced inactivation of fumarase when used at a concentration of 2 mM and penetrates into the lens of isolated bovine eyes. Ibuprofen carboxylic acid has been found in bank filtrate and surface water, as well as influent and effluent wastewater, and is considered a micropollutant.
T67498	3-Amino-1,2,4-triazole Amitrole,3-AT,1H-1,2,4-Triazol-5-amine,Trapidil impurity B	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	3-Amino-1,2,4-triazole (Trapidil impurity B) 是一种过氧化氢酶抑制剂，能够诱导过氧化氢解毒的补偿机制。该机制涉及增加谷胱甘肽过氧化物酶和谷胱甘肽还原酶的活性。
T81121	SP4e	PPAR	DNA Damage/DNA Repair; Metabolism
	SP4e是一种PPAR-γ激活剂，其在HK-2细胞中展现出的EC50为739 nM。在瑞士白化病小鼠模型中，SP4e能有效降低血糖和脂质过氧化水平，并提升谷胱甘肽含量及过氧化氢酶的活性。
T36057	Diallyl Tetrasulfide ICD-1585
	Diallyl tetrasulfide is an organosulfur compound that has been found in A. sativum and has diverse biological activities, including antimicrobial, antioxidant, and anticancer properties.[1],[2],[3],[4] It is active against the bacteria S. aureus and methicillin-resistant S. aureus (MRSA; MICs = 0.5 and 2 mg/L, respectively), as well as the fungi C. albicans, C. krusei, C. glabrata, A. niger, A. flavus, and A. fumigatus (MICs = 0.5, 4, 2, 1, 2, and 4 mg/L, respectively).[1] It reduces cadmium-ind...
T36176	AMK (hydrochloride)
	AMK is an active metabolite of the neurohormone melatonin .1,2,3,4It is formed from melatoninviathe metabolic intermediate AFMK that is then deformylated by catalase or formamidase.5,6AMK scavenges singlet oxygenin vitrowhen used at a concentration of 200 μM.1It inhibits the epinephrine- and arachidonic acid-induced production of prostaglandin E2and PGD2in ovine seminal vesicle microsomes in a concentration- and time-dependent manner, as well as LPS-induced increases in COX-2 levels in RAW 264.7...

化合物

Manganese(salen) chloride

Cat.No: T40612

Synonym: EUK-8

Target: Others

Cat.No: T6495

Synonym: EUK 134,乙基双亚氨基甲基愈创木酚锰氯化物

Target: Beta Amyloid

Cat.No: T9734

Target: CDK

2-Pyridinecarbohydrazide

Cat.No: T1374

Synonym: 2-吡啶甲酰肼,2-Picolinyl hydrazide

Target: Dehydrogenase, CAT

Cat.No: T68342

Cat.No: T81120

Target: PPAR

Cat.No: T69365

Dapsone hydroxylamine

Cat.No: T78517

Synonym: DDS-NOH

Target: Reactive Oxygen Species

Ibuprofen Carboxylic Acid

Cat.No: T37613

3-Amino-1,2,4-triazole

Cat.No: T67498

Synonym: Amitrole,3-AT,1H-1,2,4-Triazol-5-amine,Trapidil impurity B

Target: Reactive Oxygen Species

Cat.No: T81121

Target: PPAR

Diallyl Tetrasulfide

Cat.No: T36057

Synonym: ICD-1585

AMK (hydrochloride)

Cat.No: T36176

Cat. No.	Product Name	Target	Signaling Pathways
T19229	Catalase	Others	Others
	Catalase 是重要的抗氧化酶,在清除 ROS 及维持氧化还原状态的平衡方面发挥着重要作用。Catalase 与肿瘤的发生,发展关系密切。有潜力用于肿瘤的预防研究。
T4455	DL-3-Phenyllactic acid DL-3-苯乳酸,3-Phenyllactic acid,2-Hydroxy-3-phenylpropanoic acid	Others; Endogenous Metabolite; Antibacterial	Metabolism; Microbiology/Virology; Others
	DL-3-Phenyllactic acid (3-Phenyllactic acid) 是广谱抗菌化合物，对细菌和真菌具有活性。
TJS1382	Taraxerone 蒲公英赛酮	Dehydrogenase	Metabolism
	Taraxerone 是分离自景天的天然产物。它可以增强乙醇脱氢酶和乙醛脱氢酶活性，EC50分别为 512.42 μM 和 500.16 μM。
T4707	3-Hydroxyanthranilic acid 3-HYDROXY-2-AMINOBENZOIC ACID,3-羟基-2-氨基苯甲酸	Others; Endogenous Metabolite	Metabolism; Others
	3-Hydroxyanthranilic acid (3-HYDROXY-2-AMINOBENZOIC ACID) 是犬尿氨酸途径中的色氨酸代谢物。它已在人类表皮和膀胱组织中发现，并且在多种生物体液中也已检测到，例如尿液和血液。在细胞内，它主要位于细胞质中。它存在于从酵母到人类的所有真核生物中。

天然产物

Cat.No: T19229

Target: Others

DL-3-Phenyllactic acid

Cat.No: T4455

Synonym: DL-3-苯乳酸,3-Phenyllactic acid,2-Hydroxy-3-phenylpropanoic acid

Target: Others, Endogenous Metabolite, Antibacterial

Cat.No: TJS1382

Synonym: 蒲公英赛酮

Target: Dehydrogenase

3-Hydroxyanthranilic acid

Cat.No: T4707

Synonym: 3-HYDROXY-2-AMINOBENZOIC ACID,3-羟基-2-氨基苯甲酸

Target: Others, Endogenous Metabolite

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