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4

抑制剂 & 化合物

1

天然产物

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Cat. No. Product Name Target Signaling Pathways
T14064 8-Bromo-cGMP sodium

Calcium Channel; PKA Membrane transporter/Ion channel; Metabolism; Tyrosine Kinase/Adaptors
8-Bromo-cGMP sodium 是一种 PKG 激活剂, 是 cGMP 的膜渗透性类似物。8-Bromo-cGMP sodium 具有缓解疼痛和血管舒张作用,可显着抑制 Ca2+ 宏观电流,抑制高 K+ 刺激的胰岛素释放。
T11038 Dibutyryl-cGMP sodium

Bt2cGMP sodium

Others Others
Dibutyryl-cGMP sodium (Bt2cGMP sodium) is a cell-permeable cGMP analog. Dibutyryl-cGMP sodium preferentially activates cGMP-dependent protein kinase (PKG). Dibutyryl-cGMP sodium inhibits [3H]-arachidonic acid release in human platelets stimulated by gamma
T15670 KT5823

Apoptosis; PKA Apoptosis; Tyrosine Kinase/Adaptors
KT5823 是一种具有选择性和有效性的 cGMP 依赖性蛋白激酶 (PKG) 抑制剂,对 PKA 和 PKG 有抑制作用。KT5823 在甲状腺细胞中通过调节碘化钠交感蛋白的表达和活性来增加甲状腺刺激激素诱导的 (Na+/I- symporter) NIS 表达和碘离子摄取。 KT5823 诱导细胞凋亡。
T71141 Fenspiride-d5

Fenspiride-d5 is intended for use as an internal standard for the quantification of fenspiride by GC- or LC-MS. Fenspiride is an antagonist of histamine H1 receptors and a non-steroidal anti-inflammatory drug (NSAID). It inhibits histamine-induced contraction of isolated guinea pig trachea but not histamine-induced inotropy of isolated guinea pig heart. It also inhibits phosphodiesterase 4 (PDE4), PDE5, and PDE3 (IC50s = 69, ~158, and 363 µM, respectively, in isolated human bronchi derived from ...

化合物

8-Bromo-cGMP sodium
Cat.No: T14064
Synonym:
Target: Calcium Channel, PKA
Dibutyryl-cGMP sodium
Cat.No: T11038
Synonym: Bt2cGMP sodium
Target: Others
KT5823
Cat.No: T15670
Synonym:
Target: Apoptosis, PKA
Fenspiride-d5
Cat.No: T71141
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T5065 GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD

Monosodium-GMP,cGMP sodium salt,鸟苷-3',5'-环磷酸一钠盐,Cyclic GMP

PKA Tyrosine Kinase/Adaptors
GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD (cGMP sodium salt) 也称为 cGMP,是一种细胞调节剂,被描述为第二信使。它的水平随着各种激素的增加而增加,包括乙酰胆碱、胰岛素和催产素。 cGMP 激活蛋白激酶 G(PKG) 并调节离子通道电导,信号传导影响多种过程,包括平滑肌松弛和增殖、光转导和能量稳态。

天然产物

GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD
Cat.No: T5065
Synonym: Monosodium-GMP,cGMP sodium salt,鸟苷-3',5'-环磷酸一钠盐,Cyclic GMP
Target: PKA
TargetMol Loading
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