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Search Results for " arnt "

Targets Recommended: Others

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T81646	NPAS3-IN-1	Others	Others
	NPAS3-IN-1 是一种有效的 NPAS3-ARNT 异二聚化抑制剂，通过在细胞层面上调控NPAS3与ARNT的异二聚化来调控 NPAS3的转录。
T61822	M1002	HIF	Angiogenesis; Chromatin/Epigenetic
	M1002 是一种缺氧诱导因子-2 (HIF-2) 激动剂，可以增强HIF-2alpha和ARNT对转录激活的亲和力。M1002能够改变HIF-281alpha PAS-B结构域的Tyr2构象，与脯氨酰羟化酶结构域 (PHD) 抑制剂可发挥协同作用。
T67831	HIF-2α agonist 2	HIF/HIF Prolyl-Hydroxylase; HIF	Angiogenesis; Chromatin/Epigenetic; Metabolism
	HIF-2α agonist 2 是一种 HIF-2α 激动剂，对HIF-2α的EC50 值为 1.68 μM。HIF-2α agonist 2可以促进HIF-2a-ARNT 复合物3z 结构中ARNT A/B 环的稳定性，对 786-O-HRE-Luc 细胞无细胞毒性。HIF-2α agonist 2可用于氧代谢研究，与癌症的发生密切相关。
T7802	M1001	HIF/HIF Prolyl-Hydroxylase; HIF	Angiogenesis; Chromatin/Epigenetic; Metabolism
	M1001 是较弱的HIF-2α激动剂，直接与 HIF-2α PAS-B 结构域结合，Kd=667 nM，能够提高 HIF-2α-ARNT 复合体之间的稳定性。
T60539	KG-548
	KG-548 是一种ARNT/TACC3干扰剂以及HIF-1α抑制剂。KG-548 通过 ARNT 的 PAS-B 结构域与 TACC3 竞争性结合，直接干扰ARNT/TACC3复合物的形成。ARNT 是芳基烃受体核转运蛋白，也称为 HIF-β。
T69080	T1001
	T1001 is an antagonist of hypoxia-inducible factor-2α subunit (HIF-2α) which displaces residue M252 from inside the HIF-2α PAS-B pocket toward the ARNT subunit to weaken heterodimerization.

化合物

Target: HIF/HIF Prolyl-Hydroxylase, HIF

M1001

Cat.No: T7802

Synonym:

Target: HIF/HIF Prolyl-Hydroxylase, HIF

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00957	ARNT Protein, Human, Recombinant (His) Hypoxia-inducible factor 1-beta,Class E basic helix-loop-hel...	Human	P. pastoris (Yeast)
	ARNT Protein, Human, Recombinant (His) is expressed in Yeast.
TMPH-02379	arnT Protein, Klebsiella pneumoniae, Recombinant (His) Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase,4-amino-...	Klebsiella pneumoniae	E. coli
	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
TMPY-01709	HIF-1 alpha Protein, Human, Recombinant (His) bHLHe78,HIF-1 α,hypoxia inducible factor 1, alpha subunit (b...	Human	E. coli
	HIF-1 alpha, also known as HIF1A, contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. It is one of the two subunits of Hypoxia-inducible factor-1 (HIF1). HIF1 is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has...