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Search Results for " antiestrogenic "

12

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8984	FLTX1	Estrogen Receptor/ERR; Estrogen/progestogen Receptor	Endocrinology/Hormones
	FLTX1 is a fluorescent derivative of Tamoxifen, designed to efficiently target and label intracellular Tamoxifen-binding sites (estrogen receptors) both under permeabilized and non-permeabilized conditions. Additionally, FLTX1 demonstrates strong antiestrogenic activity in breast cancer cells, resembling the potent antiestrogenic properties of Tamoxifen. Notably, FLTX1 does not exhibit any estrogenic agonistic effect on the uterus.
T2569	Chlorotrianisene tris(p-methoxyphenyl)chloroethylene,氯丁烯二烯,CTA,tri-p-anisylchloroethylene,氯烯雌醚,TACE	Estrogen Receptor/ERR; Estrogen/progestogen Receptor; COX	Endocrinology/Hormones; Immunology/Inflammation; Neuroscience
	Chlorotrianisene (tri-p-anisylchloroethylene) 是长效、可口服、亲脂性高的合成三苯乙烯 (TPE) 衍生物和选择性雌激素受体调节剂，有雌激素活性，也有抗雌激素活性。它还有效抑制COX-1并抑制全血中的血小板聚集。
T11200	Endoxifen (E-isomer) N-去甲-4-羟基-三苯氧胺,E-Endoxifen,Endoxifen E-isomer	Estrogen Receptor/ERR	Endocrinology/Hormones
	Endoxifen E-isomer (E-Endoxifen) 是一种 Endoxifen 的 E-异构体，是 Endoxifen Z-isomer 原料中主要的杂质。Endoxifen E-isomer 具有抗雌激素活性。
T9796	22393-62-0_peak 2
	22393-62-0_peak 2 exhibits some aspects of the antiestrogenic activity and other actions that may be connected to the estrogenic properties. A mixture of the (Z)- and (E)-isomers (Broparestrol, INN) is used in dermatology.
T27884	LY 183648 LY-183648,LY183648
	LY 183648 has antiestrogenic activity. LY117018 inhibited PAIII metastasis to the gluteal (97%) and iliac lymph nodes (88%).
T26154	RU 45144 RU45144,RU-45144
	RU 45144 is an estradiol derivative with antiestrogenic activity.
T12312	OP-1074	Estrogen/progestogen Receptor	Endocrinology/Hormones
	OP-1074 is a pure antiestrogen and a selective degrader of ER, shows specific antiestrogenic activity for ERα and ERβ.
T13415	Zuclomiphene citrate	Others	Others
	Zuclomiphene citrate is a cis isomer of Clomiphene citrate, and has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer.
T61161	HIF-1α-IN-3
	HIF-1α-IN-3, also known as Compound (S)-3f, is a hypoxia-selective inhibitor of HIF-1α. It exhibits potent antiestrogenic activity [1].
T39259	Arzoxifene LY353381,Arzoxifene,SERMIII
	Arzoxifene (LY353381) is an orally active selective estrogen receptor modulator (SERM) exhibiting a fixed ring structure analogous to raloxifene. This compound demonstrates potent antiestrogenic effects on breast cancer and endometrium while displaying minimal side effects. Additionally, Arzoxifene elicits favorable estrogenic effects on bone health and lipid profile.
T12148L	N-Desmethyltamoxifen	Others	Others
	N-Desmethyltamoxifen, the principal metabolite of tamoxifen in humans, serves as an efficacious modulator of ceramide metabolism within human AML cells by inhibiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation. Although it demonstrates weak antiestrogenic properties, it acts as a protein kinase C (PKC) inhibitor with a potency ten times greater than that of tamoxifen.
T69696	TAS-108 citrate
	TAS-108, also known as SR16234, is a synthetic, antiestrogenic steroidal compound with potential antitumor activity. TAS-108 binds to and inhibits estrogenic receptor alpha (ERa), mainly expressed in the mammary gland and uterus and upregulated in estrogen-dependent tumors. Blockage of ERa by TAS-108 prevents the binding and effects of estrogen and may lead to an inhibition of estrogen-dependent cancer cell proliferation. TAS-108 also is a partial agonist of the estrogenic receptor beta (ERb), e...

化合物

Cat.No: T8984

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Chlorotrianisene

Cat.No: T2569

Synonym: tris(p-methoxyphenyl)chloroethylene,氯丁烯二烯,CTA,tri-p-anisylchloroethylene,氯烯雌醚,TACE

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, COX

Endoxifen (E-isomer)

Cat.No: T11200

Synonym: N-去甲-4-羟基-三苯氧胺,E-Endoxifen,Endoxifen E-isomer

Target: Estrogen Receptor/ERR

22393-62-0_peak 2

Cat.No: T9796

Cat.No: T27884

Synonym: LY-183648,LY183648

Cat.No: T26154

Synonym: RU45144,RU-45144

Cat.No: T12312

Target: Estrogen/progestogen Receptor

Zuclomiphene citrate

Cat.No: T13415

Target: Others

Cat.No: T61161

Cat.No: T39259

Synonym: LY353381,Arzoxifene,SERMIII

N-Desmethyltamoxifen

Cat.No: T12148L

Target: Others

TAS-108 citrate

Cat.No: T69696

Cat. No.	Product Name	Target	Signaling Pathways
T3855	Tracheloside	Estrogen Receptor/ERR; Phosphorylase	Endocrinology/Hormones; Metabolism
	Tracheloside 是抗雌激素木质素，利用 ERK1/2 刺激促进角质形成细胞增殖，是一种良好的促进伤口愈合的药物。
T7999	7-Hydroxyflavanone	Anti-infection	Microbiology/Virology
	7-Hydroxyflavanone 对肺炎链球菌临床分离株显示出抗菌活性。
TN4565	Millewanin G	Others	Others
	Millewanin G shows antiestrogenic activity.
TN4566	Millewanin H	Others	Others
	Millewanins H shows antiestrogenic activity.
TN4731	Pachyaximine A	Antifection	Microbiology/Virology
	Pachyaximine A possesses significant antibacterial activity against Escherichia coli, Staphylococcus aureus, Corynebacterium diphtheriae and Corynebacterium pyrogenes. (-)-Pachyaximine A demonstrates significant activity as antiestrogen binding site (AEBS

天然产物

Cat.No: T3855

Target: Estrogen Receptor/ERR, Phosphorylase

7-Hydroxyflavanone

Cat.No: T7999

Target: Anti-infection

Cat.No: TN4565

Target: Others

Cat.No: TN4566

Target: Others

Cat.No: TN4731

Target: Antifection

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