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Cat. No. | Product Name | Target | Signaling Pathways |
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T16832 |
S18-000003
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ROR | Metabolism |
S18-000003 是口服有活性的维甲酸相关孤儿受体 (RORγt) 选择性抑制剂,在竞争性结合试验中,对 hRORγt 的 IC50值小于 30 nM。它对 RORγt 的选择性比其他 ROR 家族成员 (IC50>10 μM)更高。它可用于银屑病的研究,胸腺畸变风险较低。 | |||
T26637 |
Antipain dihydrochloride
Antipain 2HCl,BDBM-32804,BDBM 32804, Antipain,BDBM32804 |
Protease | Proteases/Proteasome |
Antipain dihydrochloride (Antipain 2HCl) 是一种从 Actinomycetes 提取到的蛋白酶抑制剂,具有镇痛活性,抑制 X 射线诱导的人淋巴细胞染色体畸变。 | |||
T5983 |
o-Phenanthroline
1,10-菲罗啉,1,10-Phenanthroline |
MMP; Others | Others; Proteases/Proteasome |
o-Phenanthroline (1,10-Phenanthroline) 是一种金属螯合剂,能够与 Fe2+形成红色螯合物,在 510 nm 处最大吸收,可防止链脲佐菌素诱导染色体畸变。它也是一种MMP 的抑制剂。 | |||
T14295 | Antipain | Others | Others |
Antipain is a protease inhibitor isolated from Actinomycetes. Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations[1][2]. | |||
T70229 |
Laromustine
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Laromustine is a sulfonyl hydrazine prodrug with antineoplastic activity. Laromustine releases the DNA chloroethylating agent 90CE after entering the blood stream; 90CE chloroethylates alkylates the 06 position of guanine, resulting in DNA crosslinking, strand breaks, chromosomal aberrations, and disruption of DNA synthesis. Intracellular metabolism of this agent also releases methyl isocyanate which inhibits 06-alkyl-guanine transferase, an enzyme involved with DNA repair. | |||
T35993 |
Epitalon (acetate)
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Epitalon is a synthetic tetrapeptide with anti-aging properties.1,2,3,4 Dietary administration of epitalon (0.00001% w/w) reduces levels of lipid peroxidation products in aged D. melanogaster tissue homogenates.1 Epitalon (1 μg/animal) delays age-related estrous shutdown and decreases the frequency of bone marrow cell chromosomal aberrations in female mice.2 It decreases spontaneous mammary gland and ovarian tumor development and metastasis in aged female mice.3 Epitalon also stimulates melatoni... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T4730 |
Thymidine-5'-monophosphate disodium salt
胸苷酸二钠,Thymidine 5'-monophosphate disodium salt,TMP DISODIUM SALT |
Others; Endogenous Metabolite | Metabolism; Others |
Thymidine-5'-monophosphate disodium salt (TMP DISODIUM SALT) 是内源性代谢产物的一种。 | |||
T40834 |
5-Hydroxymethyl-2'-deoxycytidine
5hmdC,2'-脱氧-5-(羟甲基)胞啶 |
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
5-Hydroxymethyl-2'-deoxycytidine 是 DNA 中 5-methyl-2'-deoxycytidine (5-mdC) 的氧化衍生物,引起DNA损伤反应,染色体畸变,复制叉损伤和细胞活力丧失。5-Hydroxymethyl-2’-deoxycytidine 复制叉不稳定性与染色质上聚(ADP-核糖)聚合酶1(PARP1)的存在有关。 | |||
TN1929 |
Methyl sinapate
芥子酸甲酯 |
Others | Others |
Methyl sinapate can increase the frequency of cells with chromosome aberrations in the CHO K-1 cells treated with MMC, 4NQO or UV. | |||
TN4249 | Ilicol | Others | Others |
Pinocembrin and Ilicol inhibit root growth and show IC50 (root growth) values of 0.199, 14.68, 8.05, 7.69 mM, and 1.22, 2.90, 7.35, 8.07 mM, against P. miliaceum, A. sativa, L. sativa, and R. sativus, respectively. They reduce Allium cepa cell |