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Cat. No.	Product Name	Target	Signaling Pathways
T39229	YNT-185	OX Receptor	GPCR/G Protein; Neuroscience
	YNT-185 是一种非肽类、选择性的俄睾丸激素2型受体(OX2R)激动剂，对 OX2 R和 OX1R 的 EC50 值分别为 0.028 μM 和 2.75 μM。此外，YNT-185 在小鼠模型中有效缓解了嗜睡症-猝倒症的症状。
T37112	YNT-185 dihydrochloride
	Potent and selective orexin OX2 receptor agonist (EC50 = 28 nM at human OX2 expressed in CHO cells). Displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells). Depolarizes OX2-expressing histaminergic neurons in mouse brain slices. Increases wake time in wild type mice. Suppresses cataplexy-like symptoms in OX knockout mice. Nagahara et al (2015) Design and synthesis of non-peptide, selective orexin receptor 2 agonists. J.Med.Chem. 58 7931 ...