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14

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T23173	Ponceau S 丽春红 S,Acid Red 112,Ponceau S Staining Solution	Others	Others
	Ponceau S (Ponceau S Staining Solution) 是一种常见的、用于 Western blot 的染色剂。它以酸性水溶液形式使用，能够与抗体-抗原结合兼容，将膜上的蛋白质染成红色。
T21343	PTZ-343 PTZ-343 sodium,PTZ 343,吩噻嗪-10-基-丙基磺酸钠盐	Others	Others
	PTZ-343 是一种鲁米诺的强效发光增强剂 (enhancer)。它极大的增强了过氧化物酶催化的鲁米诺化学发光氧化反应 (>80%) 的光输出。
T19032	Nitro blue tetrazolium chloride NBT,氯化硝基四氮唑兰	NO Synthase	Immunology/Inflammation
	Nitro blue tetrazolium chloride (NBT) 是一种脱氢酶底物，能够与碱性磷酸酶底物 BCIP 一起用于 western blotting 和免疫组化染色。
T18896	5(6)-FITC Fluorescein 5(6)-isothiocyanate,异硫氰酸荧光素,Fluorescein isothiocyanate	Others	Others
	5(6)-FITC (Fluorescein isothiocyanate), or Fluorescein 5(6)-isothiocyanate, is a versatile amine-reactive derivative of fluorescein dye. It serves as an effective label for antibodies and other probes, finding utility in fluorescence microscopy, flow cytometry, and immunofluorescence-based assays such as ELISA and Western blotting.
T23355	Signal Enhancer Hikari	Others	Others
	Signal enhancer for use in western blotting, dot blotting and ELISA
T75587	Dendroaspis Viridis Venom
	Dendroaspis Viridis Venom (Western Green Mamba Venom) 是从 Dendroaspis Viridis (绿曼巴蛇) 提取的蛇毒，其中含有多种毒蕈碱毒素亚型，这些亚型靶向不同的毒蕈碱受体 (mAChR)。该毒液是一种由小分子和多肽/蛋白质组成的复杂混合物，显示出神经毒性、细胞毒性、心脏毒性、肌肉毒性以及多种酶活性。进一步研究表明，这些毒素具有抗肿瘤、抗菌、抗凝和镇痛的潜在活性。
TP1357	Human IgG1 Control
	Human IgG1 Control was purified from Human serum by chromatography.Human IgG1 Control can be used as a Control, standard, blocking agent, or coating protein in a variety of experiments, including ELISA, Western and blotting, immunoprecipitation, and immun
T1405L	Cefditoren sodium Cefditoren pivoxil,Cefditoren,ME-1206,ME1206,ME 1206
	Cefditoren sodium is a cephalosporin antibiotic potentially for the treatment of bacterial infection. The expression levels of Mrp2, Bcrp, Oat2 mRNA were markedly increased, while P-gp and Oct1 mRNA were decreased. In concordance with RT-PCR results, Mrp2
T35419	τ-Fluvalinate
	τ-Fluvalinate is a pyrethroid acaricide.1It induces tail currents in Western honeybee (A. mellifera) voltage-gated sodium channels (AmNav1) expressed inXenopusoocytes (EC50= 60 nM). It also induces tail currents in honeybee parasitic Varroa mite (V. destructor) Nav1 channels (VdNav1) expressed inXenopusoocytes (EC50= 160 nM) with a faster tail current decay than that of AmNav1 channels. Topical application of τ-fluvalinate (2 μl) in combination with coumaphos , atrazine , 2,4-DMPF, chlorpyrifos ...
T36406	Pyrrolidine Linoleamide
	Linoleic acid is an essential fatty acid and one of the most abundant polyunsaturated fatty acids in the western diet. Pyrrolidine Linoleamide is a derivative of the amide of linoleic acid that shows potent antiproliferative activity against an array of cancer cell lines, including human glioma U251 cells. It is greater than 4-fold more effective against cancer cells than non-cancer cells.
T79764	PF-07202954	Acyltransferase	Metabolism
	PF-07202954为一种弱碱性DGAT2抑制剂，其对人类DGAT2的IC50值为10 nM。在西方饮食喂养的大鼠模型中，PF-07202954能有效降低肝脏内的甘油三酯含量。
T37224	(±)5(6)-EpETE methyl ester
	(±)5(6)-EpETE methyl ester is a derivative of 5(6)-EpETE which is stable enough to ship and handle routinely.(±) 5(6)-EpETE methyl ester is a chemically less reactive derivative of 5(6)-EpETE. The active free acid can be generated from the methyl ester by careful base hydrolysis. Epoxy eicosatetraenoic acids (EpETEs) are the epoxygenase metabolites of EPA. A number of vicinal diol metabolites of EpETEs have been detected in the plasma of patients on marine oil dietary supplementation, while in s...
T70962	MHY219
	MHY219 is a novel HDAC inhibitor. MHY219 induces apoptosis via up-regulation of androgen receptor expression in human prostate cancer cells. MHY219 was shown to enhance the cytotoxicity on DU145 cells (IC50, 0.36 μM) when compared with LNCaP (IC50, 0.97 μM) and PC3 cells (IC50, 5.12 μM). MHY219 showed a potent inhibition of total HDAC activity when compared with SAHA. MHY219 increased histone H3 hyperacetylation and reduced the expression of class I HDACs (1, 2 and 3) in prostate cancer cells. M...
T36717	RWJ-56110 dihydrochloride
	RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride inhibits the aggregation of human platelets induced by both SFLLRN-NH2 (IC50=0.16 μM) and thrombin (IC50=0.34 μM), quite selective relative to U46619 . RWJ-56110 dihydrochloride blocks angiogenesis and blocks the formation of new vessels in vivo. RWJ-56110 dihydrochloride induces cell ap...

化合物

Cat.No: T23173

Synonym: 丽春红 S,Acid Red 112,Ponceau S Staining Solution

Target: Others

Cat.No: T21343

Synonym: PTZ-343 sodium,PTZ 343,吩噻嗪-10-基-丙基磺酸钠盐

Target: Others

Nitro blue tetrazolium chloride

Cat.No: T19032

Synonym: NBT,氯化硝基四氮唑兰

Target: NO Synthase

Cat.No: T18896

Synonym: Fluorescein 5(6)-isothiocyanate,异硫氰酸荧光素,Fluorescein isothiocyanate

Target: Others

Signal Enhancer Hikari

Cat.No: T23355

Target: Others

Dendroaspis Viridis Venom

Cat.No: T75587

Human IgG1 Control

Cat.No: TP1357

Cefditoren sodium

Cat.No: T1405L

Synonym: Cefditoren pivoxil,Cefditoren,ME-1206,ME1206,ME 1206

Cat.No: T35419

Pyrrolidine Linoleamide

Cat.No: T36406

Cat.No: T79764

Target: Acyltransferase

(±)5(6)-EpETE methyl ester

Cat.No: T37224

Cat.No: T70962

RWJ-56110 dihydrochloride

Cat.No: T36717

Cat. No.	Product Name	Target	Signaling Pathways
T10109	3-Carene Delta-3-Carene	COX; Antifungal	Immunology/Inflammation; Microbiology/Virology; Neuroscience
	3-Carene（Delta-3-Carene）是西部落叶松和花旗松中提取的双环单萜烯，可做为植物杀菌剂。3-Carene 对痛觉刺激引起的炎症浸润和 COX-2 过表达有抑制作用。3-Carene 具有抗伤害作用，能促进成骨细胞分化的早期标志物碱性磷酸酶的活性和表达。

天然产物

Cat.No: T10109

Synonym: Delta-3-Carene

Target: COX, Antifungal

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