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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T19123	3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 25-Hydroxy Vitamin D3 3,3’-Aminopropyl Ether	Others	Others
	3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 is a Vitamin D3 derivative.
T74208	Pyrocholecalciferol
	Pyrocholecalciferol 一种维生素 D 类似物，由 7-脱氢胆固醇 (7-DHC) 的光化学转化产生。
T78944	VDR agonist 2
	VDR agonist 2（化合物16i）作为VDR（vitamin D receptor）激动剂，能有效抑制TGF-β1诱导的肝星状细胞（HSC）活化，并在体外和体内展现出显著的抗肝纤维化效果。
T36593	TEI-9648
	TEI-9648, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9648 has the potential for bone metabolism research[1][2]. TEI-9648 (10-1000 nM) dose-dependently blocks the reciprocal changes of CD11b and CD71 expression associated with HL-60 cell differentiation induced by 1α,25(OH)2D3[1]. TEI-9648 has cons...
T74736	2MD
	2MD是一种口服活性维生素D类似物，能刺激骨膜骨形成并减少小梁骨吸收，从而恢复小梁和皮质骨的质量与强度。在非人灵长类动物研究中，2MD还可以调节(IOP)相关基因，降低眼压。
T36137	Biotin (S)-sulfoxide
	Biotin (S)-sulfoxide is an inactive metabolite of the coenzyme biotin .1,2It has also been found inE. coliand is reduced by the biotin sulfoxide reduction system as a source of biotin.3 1.Denkel, L.A., Rhen, M., and Bange, F.-C.Biotin sulfoxide reductase contributes to oxidative stress tolerance and virulence in Salmonella enterica serovar TyphimuriumMicrobiology (Reading)159(Pt 7)1447-1458(2013) 2.Carling, R.S., and Turner, C.Methods for assessment of biotin (Vitamin B7)Laboratory assessment of...
T13292	VDR agonist 1	Others	Others
	VDR agonist 1 (compound 28) 是一种非甾体类维生素 D 受体 (VDR)的激动剂，在MCF-7 细胞中测得其IC50值为 690 nM。VDR agonist 1 通过上调 p21 和 p27 的表达来抑制细胞周期，通过增加 BAX 的表达来促进细胞凋亡，降低 Bcl-2 的表达，具有治疗乳腺癌的潜力。
T35604	Osteocalcin (1-49) (human) (trifluoroacetate salt)
	Osteocalcin (1-49) is a non-collagenous peptide that is secreted by osteoblasts and odontoblasts and comprises 1-2% of the total protein in bone. Secretion of osteocalcin (1-49) is stimulated by 1,25-dihydroxy vitamin D and plasma levels increase in diseases that induce dysregulated bone turnover such as osteoporosis, Paget's disease, and primary hyperparathyroidism. Osteocalcin (1-49) is positively correlated with insulin sensitivity and negatively correlated with high blood glucose levels in w...

化合物

3-O-(2-Aminoethyl)-25-hydroxyvitamin D3

Cat.No: T19123

Synonym: 25-Hydroxy Vitamin D3 3,3’-Aminopropyl Ether

Osteocalcin (1-49) (human) (trifluoroacetate salt)

Cat.No: T35604

Synonym:

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T1086	Vitamin D2 Calciferol,Ergocalciferol,Ercalciol,维生素D2	DNA/RNA Synthesis; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Vitamin D2 (Calciferol) 来源于植物或膳食补充剂，能够用作维生素 D 的补充剂。
T19676	Tributyrin NSC661583,NSC 661583,NSC-661583,甘油三丁酸酯	Apoptosis	Apoptosis
	Tributyrin (Glyceryl tributyrate) 是一种中性短链脂肪酸甘油三酯，是一种稳定且吸收迅速的丁酸前药。它通过生物膜扩散并被细胞内脂肪酶代谢，在体内将有效的丁酸直接释放到细胞中，有抗增殖、促凋亡和诱导分化作用。
T10077	2-O-β-D-Glucopyranosyl-L-ascorbic acid AA-2βG,抗坏血酸葡糖苷	Others	Others
	2-O-β-D-Glucopyranosyl-L-ascorbic acid (AA-2βG) is isolated from Lycium Fruit. It is a stable vitamin C analog with anti-tumor activity.
T80862	Vitamin B15 hemicalcium Pangamic Acid hemicalcium
	Vitamin B15 (Pangamic Acid) hemicalcium 是一种自然存在于植物种子中的化合物，具有促进细胞呼吸的作用。它包含了D-葡萄糖基二甲基氨基乙酸，并可作为免疫校正剂。Vitamin B15 hemicalcium 在多种疾病研究中有应用。