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7

抑制剂 & 化合物

13

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T38294	4-Deoxypyridoxine hydrochloride	S1P Receptor	GPCR/G Protein
	4-Deoxypyridoxine hydrochloride 通过抑制 S1P 裂解酶 (SPL) 活性来抑制细胞内 S1P 的降解，与 S1P 一样，减少化学诱导的胰岛素瘤细胞系的细胞凋亡。
T20735	Pyrithioxin dihydrochloride Pyrithioxine HCl,Life,NSC 526973,盐酸吡硫醇,NSC526973,NSC-526973,Pyrithioxine hydrochloride
	Pyrithioxine HCl, a neurotropic agent, reduces the permeability of the blood-brain barrier to phosphate. It has no activity of vitamin B6.
T78509	Pyridoxal Pyridoxaldehyde	Endogenous Metabolite	Metabolism
	Pyridoxal为维生素B6的一种活性形态。
T3578L	Pyridoxal calcium phosphate
	Pyridoxal phosphate (PLP, pyridoxal 5'-phosphate, P5P), known as an active form of vitamin B6, is a coenzyme involved in many enzymatic reactions.
T75316	Pyridoxamine 5′-phosphate
	Pyridoxamine 5′-phosphate 是维生素 B6 与磷酸结合的活性形式。Pyridoxamine 5′-phosphate 是 Pyridoxal 5'-phosphate hydrate 的胺化形式，是多种酶的中心代谢物、强力抗氧化剂、维生素 B6 和酶底物的辅助因子。Pyridoxamine 5′-phosphate 能与 Pyridoxal 5'-phosphate hydrate 相互转化。
T36833	A6770
	A6770 is an inhibitor of sphingosine-1-phosphate (S1P) lyase.1It induces accumulation of [3H]sphinganine-1-phosphate ([3H]dhS1P), an S1P lyase substrate, in IT-79MTNC3 cells that endogenously express high levels of S1P lyase (EC50= <0.01 μM), an effect that is reduced in the presence of vitamin B6(EC50= <100 μM). 1.Ohtoyo, M., Tamura, M., Machinaga, N., et al.Scintillation proximity assay to detect the changes in cellular dihydrosphingosine 1-phosphate levelsLipids51(10)1207-1216(2016)
T37249	Methylmalonyl-Coenzyme A (sodium salt)
	Methylmalonyl coenzyme A (methylmalonyl-CoA) is an intermediate in multiple metabolic pathways in bacteria and eukaryotes.1,2,3It is an intermediate in carbon assimilation in certain bacteria and carbon fixation in plants.1,2Methylmalonyl-CoA is converted to succinyl-CoA by methylmalonyl-CoA mutase with vitamin B12as a coenzyme.3A deficiency in vitamin B12leads to a build-up of methylmalonyl-CoA.4 1.Anthony, C.How half a century of research was required to understand bacterial growth on C1 and C...

化合物

4-Deoxypyridoxine hydrochloride

Cat.No: T38294

Target: S1P Receptor

Pyrithioxin dihydrochloride

Cat.No: T20735

Synonym: Pyrithioxine HCl,Life,NSC 526973,盐酸吡硫醇,NSC526973,NSC-526973,Pyrithioxine hydrochloride

Cat.No: T78509

Synonym: Pyridoxaldehyde

Target: Endogenous Metabolite

Pyridoxal calcium phosphate

Cat.No: T3578L

Pyridoxamine 5′-phosphate

Cat.No: T75316

Cat.No: T36833

Methylmalonyl-Coenzyme A (sodium salt)

Cat.No: T37249

Cat. No.	Product Name	Target	Signaling Pathways
T3O2784	Vitamin B6 维生素B6	Others	Others
	Vitamin B6 是人体某些辅酶的成分，参与多种代谢反应，特别是与氨基酸代谢有关。维生素B6在防治妊娠和放射病呕吐中的临床应用。
T0973L	Pyridoxine hydrochloride Pyridoxine HCl,吡哆醇盐酸盐,Pyridoxol (hydrochloride),吡哆醇盐酸盐(维生素B6),Vitamin B6 (hydrochloride),Vitamin B6	Nrf2; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	Pyridoxine hydrochloride (Vitamin B6) 是一种吡啶衍生物。在于阿尔茨海默病细胞模型中，通过 Nrf-2/HO-1 途径发挥抗氧化作用。
T0973	Pyridoxine 吡哆醇,Pyridoxol,Vitamin B6,Gravidox,吡多素（维生素B6）	PLK; Nrf2; Endogenous Metabolite	Cell Cycle/Checkpoint; Immunology/Inflammation; Metabolism
	Pyridoxine (Vitamin B6) 是一种吡啶衍生物，通过 Nrf-2/HO-1 途径发挥抗氧化作用，作用于阿尔茨海默病细胞模型。
T0905	Pyrithioxin 吡硫醇,Pyridoxine disulfide,Encefabol,Vitamin B6 disulfide,Pyritinol,Bonifen,吡硫醇(维生素B6衍生品)	Others; Endogenous Metabolite	Metabolism; Others
	Pyrithioxin (Encefabol) 是神经动力化合物，能够促进脑内葡萄糖及氨基酸的代谢，改善全身同化作用，增加颈动脉血流量，改善脑血流。
T3578	Pyridoxal phosphate PLP,PAL-P,磷酸吡哆醛,pyridoxal 5'-phosphate,Pyridoxyl phosphate,Pyridoxal 5′-phosphate,Vitamin B6 phosphate	Reverse Transcriptase; Endogenous Metabolite	Metabolism; Microbiology/Virology
	Pyridoxal phosphate (Vitamin B6 phosphate) 是维生素 B6 的活性形式，可抑制逆转录酶活性，用于研究迟发性运动障碍症。
T8083	Pyridoxal 5'-phosphate monohydrate Pyridoxal phosphate monohydrate,Pyridoxal 5-phosphate monohydrate,5-磷酸吡哆醛	Others	Others
	Pyridoxal 5'-phosphate monohydrate 是维生素 B6的活性形式，也是多种酶的重要辅因子。它是维生素 B6 在细胞内磷酸化过程中重要的辅酶变异体，能够与其他变异体（如 PNP 、 PMP）发生互换。
T4107	4-Pyridoxic Acid 4-吡哆酸,Pyridoxic Acid,4-Pyridoxinsaeure	Endogenous Metabolite	Metabolism
	4-Pyridoxic Acid (4-Pyridoxinsaeure) 是一种维生素B6的分解代谢产物，从尿液中分泌得到。
T4754	Pyridoxylamine dihydrochloride 盐酸吡多胺,Pyridorin,Pyridoxamine dihydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	Pyridoxylamine dihydrochloride (Pyridorin) 是一种糖基化终产物和脂质化终产物抑制剂，能够防止糖尿病引起的视网膜血管病变。
T4761	Pyridoxal hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	Pyridoxal hydrochloride 是内源性代谢产物的一种。
T5085	Pyridoxal 5'-phosphate hydrate Codecarboxylase,Pyridoxal 5'-phosphate hydrate(1:x),5-磷酸吡多醛水合物,PLP,Pyridoxal 5'-phosphate hydrate	Others; Endogenous Metabolite	Metabolism; Others
	Pyridoxal 5'-phosphate hydrate (PLP) 是内源性代谢产物的一种。
T4877	L-Homocystine	Endogenous Metabolite	Metabolism
	L-Homocystine 是一种 L-homocysteine 的氧化物。其中 L-homocysteine 是抗血栓因子、血管舒张损害剂、促炎因子，也是研究心血管疾病发生机制的内质网应激反应的诱导剂。
T38479	3-Hydroxypyridine
	3-Hydroxypyridine, extracted from Bamboo grass, is a structural analogue of vitamin B6. It exhibits diverse pharmacological properties, including antioxidant activity.
T5276	4,4'-Disulfanediylbis(2-aminobutanoic acid) DL-Homocystine,DL-高胱氨酸	Others; Endogenous Metabolite	Metabolism; Others
	4,4'-Disulfanediylbis(2-aminobutanoic acid) (DL-Homocystine) 是内源性代谢产物的一种。

天然产物

Cat.No: T3O2784

Synonym: 维生素B6

Target: Others

Pyridoxine hydrochloride

Cat.No: T0973L

Synonym: Pyridoxine HCl,吡哆醇盐酸盐,Pyridoxol (hydrochloride),吡哆醇盐酸盐(维生素B6),Vitamin B6 (hydrochloride),Vitamin B6

Target: Nrf2, Endogenous Metabolite

Cat.No: T0973

Synonym: 吡哆醇,Pyridoxol,Vitamin B6,Gravidox,吡多素（维生素B6）

Target: PLK, Nrf2, Endogenous Metabolite

Cat.No: T0905

Synonym: 吡硫醇,Pyridoxine disulfide,Encefabol,Vitamin B6 disulfide,Pyritinol,Bonifen,吡硫醇(维生素B6衍生品)

Target: Others, Endogenous Metabolite

Pyridoxal phosphate

Cat.No: T3578

Synonym: PLP,PAL-P,磷酸吡哆醛,pyridoxal 5'-phosphate,Pyridoxyl phosphate,Pyridoxal 5′-phosphate,Vitamin B6 phosphate

Target: Reverse Transcriptase, Endogenous Metabolite

Pyridoxal 5'-phosphate monohydrate

Cat.No: T8083

Synonym: Pyridoxal phosphate monohydrate,Pyridoxal 5-phosphate monohydrate,5-磷酸吡哆醛

Target: Others

4-Pyridoxic Acid

Cat.No: T4107

Synonym: 4-吡哆酸,Pyridoxic Acid,4-Pyridoxinsaeure

Target: Endogenous Metabolite

Pyridoxylamine dihydrochloride

Cat.No: T4754

Synonym: 盐酸吡多胺,Pyridorin,Pyridoxamine dihydrochloride

Target: Others, Endogenous Metabolite

Pyridoxal hydrochloride

Cat.No: T4761

Target: Others, Endogenous Metabolite

Pyridoxal 5'-phosphate hydrate

Cat.No: T5085

Synonym: Codecarboxylase,Pyridoxal 5'-phosphate hydrate(1:x),5-磷酸吡多醛水合物,PLP,Pyridoxal 5'-phosphate hydrate

Target: Others, Endogenous Metabolite

Cat.No: T4877

Target: Endogenous Metabolite

3-Hydroxypyridine

Cat.No: T38479

4,4'-Disulfanediylbis(2-aminobutanoic acid)

Cat.No: T5276

Synonym: DL-Homocystine,DL-高胱氨酸

Target: Others, Endogenous Metabolite

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