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抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T3578L	Pyridoxal calcium phosphate
	Pyridoxal phosphate (PLP, pyridoxal 5'-phosphate, P5P), known as an active form of vitamin B6, is a coenzyme involved in many enzymatic reactions.
T20735	Pyrithioxin dihydrochloride Pyrithioxine HCl,Life,NSC 526973,盐酸吡硫醇,NSC526973,NSC-526973,Pyrithioxine hydrochloride
	Pyrithioxine HCl, a neurotropic agent, reduces the permeability of the blood-brain barrier to phosphate. It has no activity of vitamin B6.
T38294	4-Deoxypyridoxine hydrochloride	S1P Receptor	GPCR/G Protein
	4-Deoxypyridoxine hydrochloride 通过抑制 S1P 裂解酶 (SPL) 活性来抑制细胞内 S1P 的降解，与 S1P 一样，减少化学诱导的胰岛素瘤细胞系的细胞凋亡。
T75316	Pyridoxamine 5′-phosphate
	Pyridoxamine 5′-phosphate 是维生素 B6 与磷酸结合的活性形式。Pyridoxamine 5′-phosphate 是 Pyridoxal 5'-phosphate hydrate 的胺化形式，是多种酶的中心代谢物、强力抗氧化剂、维生素 B6 和酶底物的辅助因子。Pyridoxamine 5′-phosphate 能与 Pyridoxal 5'-phosphate hydrate 相互转化。
T36833	A6770
	A6770 is an inhibitor of sphingosine-1-phosphate (S1P) lyase.1It induces accumulation of [3H]sphinganine-1-phosphate ([3H]dhS1P), an S1P lyase substrate, in IT-79MTNC3 cells that endogenously express high levels of S1P lyase (EC50= <0.01 μM), an effect that is reduced in the presence of vitamin B6(EC50= <100 μM). 1.Ohtoyo, M., Tamura, M., Machinaga, N., et al.Scintillation proximity assay to detect the changes in cellular dihydrosphingosine 1-phosphate levelsLipids51(10)1207-1216(2016)

化合物

Pyridoxal calcium phosphate

Cat.No: T3578L

Synonym:

Target:

Pyrithioxin dihydrochloride

Cat.No: T20735

Synonym: Pyrithioxine HCl,Life,NSC 526973,盐酸吡硫醇,NSC526973,NSC-526973,Pyrithioxine hydrochloride

Target:

4-Deoxypyridoxine hydrochloride

Cat.No: T38294

Synonym:

Target: S1P Receptor

Pyridoxamine 5′-phosphate

Cat. No.	Product Name	Target	Signaling Pathways
T3578	Pyridoxal phosphate PLP,PAL-P,磷酸吡哆醛,pyridoxal 5'-phosphate,Pyridoxyl phosphate,Pyridoxal 5′-phosphate,Vitamin B6 phosphate	Reverse Transcriptase; Endogenous Metabolite	Metabolism; Microbiology/Virology
	Pyridoxal phosphate (Vitamin B6 phosphate) 是维生素 B6 的活性形式，可抑制逆转录酶活性，用于研究迟发性运动障碍症。
T8083	Pyridoxal 5'-phosphate monohydrate Pyridoxal phosphate monohydrate,Pyridoxal 5-phosphate monohydrate,5-磷酸吡哆醛	Others	Others
	Pyridoxal 5'-phosphate monohydrate 是维生素 B6的活性形式，也是多种酶的重要辅因子。它是维生素 B6 在细胞内磷酸化过程中重要的辅酶变异体，能够与其他变异体（如 PNP 、 PMP）发生互换。
T0973	Pyridoxine 吡哆醇,Pyridoxol,Vitamin B6,Gravidox,吡多素（维生素B6）	PLK; Nrf2; Endogenous Metabolite	Cell Cycle/Checkpoint; Immunology/Inflammation; Metabolism
	Pyridoxine (Vitamin B6) 是一种吡啶衍生物，通过 Nrf-2/HO-1 途径发挥抗氧化作用，作用于阿尔茨海默病细胞模型。
T0973L	Pyridoxine hydrochloride Pyridoxine HCl,吡哆醇盐酸盐,Pyridoxol (hydrochloride),吡哆醇盐酸盐(维生素B6),Vitamin B6 (hydrochloride),Vitamin B6	Nrf2; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	Pyridoxine hydrochloride (Vitamin B6) 是一种吡啶衍生物。在于阿尔茨海默病细胞模型中，通过 Nrf-2/HO-1 途径发挥抗氧化作用。
T4761	Pyridoxal hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	Pyridoxal hydrochloride 是内源性代谢产物的一种。
T5085	Pyridoxal 5'-phosphate hydrate Codecarboxylase,Pyridoxal 5'-phosphate hydrate(1:x),5-磷酸吡多醛水合物,PLP,Pyridoxal 5'-phosphate hydrate	Others; Endogenous Metabolite	Metabolism; Others
	Pyridoxal 5'-phosphate hydrate (PLP) 是内源性代谢产物的一种。