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Search Results for " vp3 "

Targets Recommended: GSK-3 PDE

2

抑制剂 & 化合物

12

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T5956	VP3.15 dihydrobromide	GSK-3; PDE	Metabolism; PI3K/Akt/mTOR signaling; Stem Cells
	VP3.15 dihydrobromide 是一种口服具有活力的、高效的、CNS 可渗透的PDE7-GSK3双重抑制剂，对 PDE7 和 GSK3 作用的IC50值分别为 1.59 μM 和 0.88 μM。它具有神经保护和神经修复作用，可用于研究多发性硬化症 (MS) 潜在的抗炎和促髓鞘再生联合。
T13310	VP3.15	Others	Others
	VP3.15 is an orally bioavailable and CNS-penetrant dual inhibitor of phosphodiesterase (PDE)7- GSK3 (IC50s: 1.59 μM and 0.88 μM for PDE7 and GSK-3).

化合物

VP3.15 dihydrobromide

Cat.No: T5956

Target: GSK-3, PDE

Cat.No: T13310

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00366	Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (GST) VP3,Apoptin	CAV	E. coli
	May act as transcriptional regulator. Induces apoptosis in infected cells. Element of infectious replication cycle. Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 40.3 kDa and the accession number is Q99152.
TMPH-00365	Chicken anemia virus (isolate USA 26p4) Apoptin Protein (His) VP3,Apoptin	CAV	E. coli
	May act as transcriptional regulator. Induces apoptosis in infected cells. Element of infectious replication cycle. Chicken anemia virus (isolate USA 26p4) Apoptin Protein (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 17.1 kDa and the accession number is P54095.
TMPH-00367	Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (His & SUMO) Apoptin,VP3	CAV	E. coli
	May act as transcriptional regulator. Induces apoptosis in infected cells. Element of infectious replication cycle. Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 29.3 kDa and the accession number is Q99152.
TMPH-02385	Lake Victoria marburgvirus (MARV) (strain Musoke-80) VP30 Protein (His & Myc)	MARV	E. coli
	Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA secondary structure at the transcription start site of the first gene.
TMPH-03733	Zaire ebolavirus (strain Kikwit-95) VP35 Protein (His & Myc)	ZEBOV	HEK293 Cells
	Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/NP monomer chaperone prior to the formation of the large oligomeric RNA-bound complexes. Regulates RNA synthesis by modulating NP-RNA interactions and interacting with DYNLL1. VP35-NP interaction controls the switch between RNA-bound NP and free NP and thus the switch between gen...
TMPH-02383	Lake Victoria marburgvirus (MARV) (strain Musoke-80) VP35 Protein (His)	MARV	E. coli
	Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling.
TMPH-03732	Zaire ebolavirus (strain Kikwit-95) VP35 Protein (E. col, His & Myc)	ZEBOV	E. coli
	Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/NP monomer chaperone prior to the formation of the large oligomeric RNA-bound complexes. Regulates RNA synthesis by modulating NP-RNA interactions and interacting with DYNLL1. VP35-NP interaction controls the switch between RNA-bound NP and free NP and thus the switch between gen...
TMPH-03729	Zaire ebolavirus (strain Kikwit-95) VP30 Protein (His)	ZEBOV	E. coli
	Multifunctional protein that acts as a viral transcriptional activator. Promotes read-through of an RNA hairpin in the NP open reading frame to enhance viral transcription. Mechanistically, nonphosphorylated VP30 hexamers form a ternary complex with the viral leader RNA. Clamps the RNA template and the complex VP35-polymerase L together, thereby increasing the polymerase affinity for the RNA template to increase transcription initiation despite the presence of RNA secondary structures. Assists a...
TMPH-00201	BK polyomavirus (BKPyV) VP2 Protein (His) Minor capsid protein VP2,Minor structural protein <...	BKPyV	E. coli
	Isoform VP2 is a structural protein that resides within the core of the capsid surrounded by 72 VP1 pentamers. Participates in host cell receptor binding together with VP1. Following virus endocytosis and trafficking to the endoplasmic reticulum, VP2 and VP3 form oligomers and integrate into the endoplasmic reticulum membrane. Heterooligomer VP2-VP3 may create a viroporin for transporting the viral genome across the endoplasmic reticulum membrane to the cytoplasm. Nuclear entry of the viral DNA ...
TMPY-02060	Human Enterovirus 71 VP0 Protein (His & GST) VP Protein,VP4-VP2 Protein	EV71	Baculovirus Insect Cells
	Human enterovirus 71 genome polyprotein is a member of the picornaviruses polyprotein family. It contains two peptidase C3 domains, one RdRp catalytic domain, one SF3 helicase domain. Genome polyprotein is cleaved into the following 12 chains: Protein VP (VP4-VP2), Protein VP4 (P1A), Protein VP2 (P1B), Protein VP3 (P1C), Protein VP1 (P1D), Picornain 2A (P2A), Protein 2B (P2B), Protein 2C (P2C), Protein 3A (P3A), Protein 3B (P3B), Picornain 3C (Protease 3C) and RNA-directed RNA polymerase 3D-POL ...
TMPH-02365	JC polyomavirus (JCV) Minor capsid protein VP2 (His)	JCPyV	E. coli
	Isoform VP2 is a structural protein that resides within the core of the capsid surrounded by 72 VP1 pentamers. Participates in host cell receptor binding together with VP1. Following virus endocytosis and trafficking to the endoplasmic reticulum, VP2 and VP3 form oligomers and integrate into the endoplasmic reticulum membrane. Heterooligomer VP2-VP3 may create a viroporin for transporting the viral genome across the endoplasmic reticulum membrane to the cytoplasm. Nuclear entry of the viral DNA ...
TMPH-00789	Hamster polyomavirus (HaPyV) VP1 Protein (His & Myc)	HaPyV	E. coli
	Forms an icosahedral capsid with a T=7 symmetry and a 40 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins. Interacts with sialic acids on the cell surface to provide virion attachment to target cell. Once attached, the virion is internalized by endocytosis and traffics to the endoplasmic reticulum. Inside the endoplasmic reticulum, the protein folding machinery isomerizes VP1 interpentamer disulfide bonds, thereby...

重组蛋白

Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (GST)

Cat.No: TMPH-00366

Species: CAV

Expression System: E. coli

Chicken anemia virus (isolate USA 26p4) Apoptin Protein (His)

Cat.No: TMPH-00365

Species: CAV

Expression System: E. coli

Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (His & SUMO)

Cat.No: TMPH-00367

Species: CAV

Expression System: E. coli

Lake Victoria marburgvirus (MARV) (strain Musoke-80) VP30 Protein (His & Myc)

Cat.No: TMPH-02385

Species: MARV

Expression System: E. coli

Zaire ebolavirus (strain Kikwit-95) VP35 Protein (His & Myc)

Cat.No: TMPH-03733

Species: ZEBOV

Expression System: HEK293 Cells

Lake Victoria marburgvirus (MARV) (strain Musoke-80) VP35 Protein (His)

Cat.No: TMPH-02383

Species: MARV

Expression System: E. coli

Zaire ebolavirus (strain Kikwit-95) VP35 Protein (E. col, His & Myc)

Cat.No: TMPH-03732

Species: ZEBOV

Expression System: E. coli

Zaire ebolavirus (strain Kikwit-95) VP30 Protein (His)

Cat.No: TMPH-03729

Species: ZEBOV

Expression System: E. coli

BK polyomavirus (BKPyV) VP2 Protein (His)

Cat.No: TMPH-00201

Species: BKPyV

Expression System: E. coli

Human Enterovirus 71 VP0 Protein (His & GST)

Cat.No: TMPY-02060

Species: EV71

Expression System: Baculovirus Insect Cells

JC polyomavirus (JCV) Minor capsid protein VP2 (His)

Cat.No: TMPH-02365

Species: JCPyV

Expression System: E. coli

Hamster polyomavirus (HaPyV) VP1 Protein (His & Myc)

Cat.No: TMPH-00789

Species: HaPyV

Expression System: E. coli

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