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抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T63647	DCN1-UBC12-IN-1
	DCN1-UBC12-IN-1 是有效的、特异性的 DCN1-UBC12 抑制剂，其 IC50 值为 2.86 nM，具有抗心脏成纤维化活性。
T63820	DCN1-UBC12-IN-2
	DCN1-UBC12-IN-2 是有效的、特异性的 DCN1-UBC12 抑制剂，其 IC50 值为 9.55 nM。DCN1-UBC12-IN-2 能够特异性靶向 DCN1-UBC12 相互作用，减缓 Ang II 诱导的心脏成纤维细胞活化。
T13349	WS-383	E1/E2/E3 Enzyme	Ubiquitination
	WS-383 是高效、选择性、可逆的DCN1-UBC12相互作用抑制剂，IC50为11 nM。它抑制 Cul3/1 的类泛素化修饰，引起 NRF2，p21和p27 的积累。
T9140	NAcM-OPT HCl(2089293-61-6 free base)	NEDD8	Metabolism
	NAcM-OPT HCl(2089293-61-6 free base) 是一种可口服的 cullin neddylation 1 (DCN1) 抑制剂，靶向 N-Acetyl-UBE2M（E2 结合酶，UBC12）与 DCN1 的相互作用，IC50 为 79 nM。
T13348	WS-383 free base	Others	Others
	WS-383 free base is a selective and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).
T23989	DI-404
	DI-404 is a high-Affinity Peptidomimetic the DCN1-UBC12 Protein-Protein Interaction inhibitor (Kd= 6.9 nM). DI-404 effectively and selectively inhibits the neddylation of cullin 3 over other cullin members.
T11033	DI-591	Others	Others
	DI-591 is an effective, high-affinity and cell-permeability inhibitor for DCN1-UBC12 interaction. DI-591 binds to DCN1 and DCN2 with Ki values of 12 and nM and 10.4 nM, respectively, and has no obvious binding to DCN3, DCN4 and DCN5 proteins.

化合物

Target: E1/E2/E3 Enzyme

NAcM-OPT HCl(2089293-61-6 free base)

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02609	UBE2M Protein, Human, Recombinant UBC12,UBC-RS2,ubiquitin-conjugati...	Human	E. coli
	UBE2M is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction, and thereby the fate of the substrate, is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To d...
TMPY-03869	DCUN1D1 Protein, Human, Recombinant (His) DCNL1,SCCRO,Tes3,RP42,SCRO,DCUN1L1,DCN1, defective in cullin...	Human	E. coli
	DCUN1D1, also known as SCCRO, is part of an E3 ubiquitin ligase complex for neddylation. DCUN1D1 functions to recruit charged E2 and is involved in the release of inhibitory effects of CAND1 on cullin-RING ligase E3 complex assembly and activity. DCUN1D1 binds to the components of the neddylation pathway (Cullin-ROC1, Ubc12, and CAND1) and augments but is not required for cullin neddylation in reactions using purified recombinant proteins. DCUN1D1 also recruits Ubc12 approximately NEDD8 to the C...