Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13237L |
Ropsacitinib
Tyk2-IN-8,PF-06826647 |
Tyrosine Kinases | Tyrosine Kinase/Adaptors |
Ropsacitinib (PF-06826647) 是一种选择性TYK2抑制剂。Ropsacitinib 与Tyk2催化活性JH1结构域结合(IC50:17nM)。 | |||
T13232 |
TyK2-IN-2
|
PDE | Metabolism |
TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα). | |||
T13234 |
Tyk2-IN-5
|
Others | Others |
Tyk2-IN-5 is a selective and orally active inhibitor of Tyk2 JH2 (Ki: 0.086 nM for Tyk2 JH2; IC50: 25 nM for IFNα). | |||
T13235 |
Tyk2-IN-7
|
Others | Others |
Tyk2-IN-7 is an inhibitor of TYK2 JH2, binds to the TYK2 JH2 domain (IC50: 0.00053 μM; Ki.app: 0.00007 μM). | |||
T13237 |
Tyk2-IN-9
|
Others | Others |
Tyk2-IN-9 (化合物26),作为一种高选择性Tyk-2抑制剂,展现出对TYK2-JH2的IC50为0.076 nM,及对JAK1-JH2的IC50为1.8 nM,显示其在炎症或自身免疫性疾病研究中的应用前景。 | |||
T13233 |
Tyk2-IN-3
|
Tyrosine Kinases | Tyrosine Kinase/Adaptors |
Tyk2-IN-3 is an inhibitor of Tyk2 pseudokinase (IC50: 485 nM). | |||
T61658 |
TYK2-IN-11
|
||
TYK2-IN-11 (Compound 5B) is a potent and selective inhibitor of Tyk-2, providing inhibition to TYK2-JH2 and JAK1-JH2 with IC50 values of 0.016 nM and 0.31 nM, respectively. This compound demonstrates potential for advancing research in the area of inflammatory and autoimmune diseases [1]. |