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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T80968	Topoisomerase I inhibitor 10	Topoisomerase	DNA Damage/DNA Repair
	TopoisomeraseI inhibitor 10 (compound 13)为一种抗利什曼原虫活性药物，特别针对L. donovani promastigotes的leishmanial topoisomerase IB表现出抑制作用，IC50值为27.91 μM。
T60123	Chimmitecan (S)-9-Allyl-10-hydroxycamptothecin,吉米替康	Topoisomerase	DNA Damage/DNA Repair
	Chimmitecan ((S)-9-Allyl-10-hydroxycamptothecin) 是一种topoisomerase I 抑制剂，在体内、外表现有效的活性。
T79883	9-Chloromethyl-10-hydroxy-11-F-Camptothecin	Topoisomerase	DNA Damage/DNA Repair
	9-Chloromethyl-10-Hydroxy-11-F-Camptothecin是一款喜树碱类衍生化合物，具有DNA拓扑异构酶I (Topo I)抑制活性，应用于癌症治疗的研究领域。
T79263	Antitumor agent-102	Topoisomerase	DNA Damage/DNA Repair
	Antitumor agent-102（compound 10）是拓扑异构酶 I（topoisomerase I）抑制剂SN38与葡萄糖转运蛋白（glucose transporter）抑制剂缀合物，专门针对结直肠癌。相较于伊立替康，该化合物在肿瘤组织中可诱导游离SN38的更高浓度。
T38731	Intoplicine dimesylate RP 60475 dimesylate
	Intoplicine (RP 60475) dimesylate is a DNA topoisomerase I and II inhibitor belonging to the 7H-benzo[e]pyrido[4,3-b]indole series. It exhibits a strong affinity for DNA (K A = 2 x 10^5 /M), resulting in increased linear DNA length.
T36695	TAS-103
	TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research. TAS-103 is a dual inhibitor of DNA topoisomerase I/II. TAS-103 (0.1-10 μM) is active on CCRF-CEM cells, with an IC50 value of 5 nM. TAS-103 (0.1 μM) significantly increases levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells[1]. TAS-103 (0.01-1 μM) is highly cytotoxic to Lewis lung carcinoma (LLC) cells, and Liposomal TAS-103 is almost as active as free TAS-103[2]. TAS-103 inhibits the viability ...

化合物

Topoisomerase I inhibitor 10

Cat.No: T80968

Synonym:

Target: Topoisomerase

Chimmitecan

Cat.No: T60123

Synonym: (S)-9-Allyl-10-hydroxycamptothecin,吉米替康

Target: Topoisomerase

9-Chloromethyl-10-hydroxy-11-F-Camptothecin

Cat.No: T79883

Synonym:

Target: Topoisomerase

Antitumor agent-102

Cat.No: T79263

Synonym:

Target: Topoisomerase

Intoplicine dimesylate

Cat.No: T38731

Synonym: RP 60475 dimesylate

Cat. No.	Product Name	Target	Signaling Pathways
T2764	(S)-10-Hydroxycamptothecin 10-羟喜树碱,10-羟基喜树碱,10-Hydroxycamptothecin,10-HCPT	Apoptosis; Topoisomerase	Apoptosis; DNA Damage/DNA Repair
	(S)-10-Hydroxycamptothecin (10-HCPT) 是一种从喜树中分离的 DNA 拓扑异构酶 I 抑制剂。它显著诱导细胞凋亡，可研究肝癌、胃癌、结肠癌和白血病。