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5

抑制剂 & 化合物

15

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T9901A-015	ABTIM3-hum03
	ABTIM3-hum03 是一种人源化的抗 TIM3 血脑屏障穿梭的单克隆抗体。
T9901A-014	ABTIM3-hum11
	ABTIM3-hum11 是一种人源化的抗 TIM3 血脑屏障穿梭的单克隆抗体。
T79365	TIM-3-IN-2	Immunology/Inflammation related	Immunology/Inflammation
	TIM-3-IN-2 是 Tim3 抑制剂，可以抑制TIM-3与PtdSer、CEACAM1和Gal-9的结合，抑制TIM-3发挥作用。TIM-3-IN-2能够逆转TIM-3介导的促炎细胞因子的作用。
T77149	Cobolimab TSR-022,GSK4069889	Others	Others
	Cobolimab (TSR-022) 是一种有效的 TIM-3 单克隆抗体。Cobolimab 诱导 TIM-3 的内化，IC50 值为 0.4464 nM。Cobolimab 具有抗肿瘤活性，可用于研究晚期/转移性黑色素瘤和晚期肝细胞癌。
T40211	eIF4E-IN-1 eIF4E-IN-1
	eIF4E-IN-1 (WO2021003194A1, compound Y), is a highly effective inhibitor of eIF4E, a key protein involved in immunosuppression. By targeting immune checkpoint proteins such as PD-1, PD-L1, LAG3, TIM3, and IDO, eIF4E-IN-1 functions to disrupt immune suppression and promote immune release in specific diseases such as cancer and infectious diseases.

化合物

Cat.No: T9901A-015

Cat.No: T9901A-014

Cat.No: T79365

Target: Immunology/Inflammation related

Cat.No: T77149

Synonym: TSR-022,GSK4069889

Target: Others

Cat.No: T40211

Synonym: eIF4E-IN-1

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05227	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His), Biotinylated TIMD3,hepatitis A virus cellular receptor ...	Human	HEK293 Cells
	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.3 kDa and the accession number is AAL65157.1.
TMPY-01621	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His) TIMD-3,hepatitis A virus cellular receptor...	Human	HEK293 Cells
	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.3 kDa and the accession number is AAL65157.1.
TMPY-03424	TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (His) hepatitis A virus cellular receptor 2,TIM-3	Mouse	HEK293 Cells
	TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.3 kDa and the accession number is AAL65156.1.
TMPJ-00189	TIM-3/KIM-3/HAVCR2 Protein, Cynomolgus, Recombinant (His) HAVCR2,Tim-3,TIM3,T cell...	Cynomolgus	HEK293 Cells
	T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid (aa)extracellular domain (ECD), a 21 aa transmembrane segment, and a 78 aa cytoplasmic tail. TIM3 is up-regulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). Its binding to Galectin9 induces a range of immunosuppressive functions which enhance...
TMPY-03677	TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (hFc) Tim3,TIM-3,hepatitis A v...	Mouse	HEK293 Cells
	TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.9 kDa and the accession number is AAL65156.1.
TMPK-00190	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (aa 22-200, His) KIM3,TIM3,TIM 3...	Human	HEK293 Cells
	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (aa 22-200, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 20.7 kDa and the accession number is Q8TDQ0-1.
TMPK-00189	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His & Avi), Biotinylated TIM 3,HAVCR2,TIMD-3,...	Human	HEK293 Cells
	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 22.8 kDa and the accession number is Q8TDQ0-1.
TMPY-06296	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc & Avi), Biotinylated HAVcr-2,KIM-3,TIM3,CD366...	Human	HEK293 Cells
	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 48.41 kDa and the accession number is Q8TDQ0-1.
TMPY-05428	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc) HAVcr-2,KIM-3,Tim-3,TIMD...	Human	HEK293 Cells
	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.6 kDa and the accession number is Q8TDQ0-1.
TMPY-05463	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (mFc) HAVCR2,TIM3,CD366,TIMD	Human	HEK293 Cells
	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 46.2 kDa and the accession number is Q8TDQ0-1.
TMPJ-00599	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc & His) TIM3,Hepatitis A virus cellular receptor 2...	Human	HEK293 Cells
	Hepatitis A virus cellular receptor 2（HAVCR2）is a single-pass type I membrane protein and it contains 1 Ig-like V-type (immunoglobulin-like) domain. The protein belongs to the immunoglobulin superfamily, and TIM family of proteins. The protein regulates macrophage activation. It inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. It may be also involved in T-cell homing and it is receptor for LGALS9. CD4 (MIM 186940)-positive T ...
TMPJ-00174	TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-193, His) T-cell immunoglobulin mucin receptor 3,Hepatitis A ...	Mouse	HEK293 Cells
	TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-193, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 38-55 KDa and the accession number is Q8VIM0.
TMPJ-00624	TIM-3/KIM-3/HAVCR2 Protein, Marmoset, Recombinant (His) Tim3,HAVcr-2,Timd3,Hepat...	Marmoset	HEK293 Cells
	TIM-3/KIM-3/HAVCR2 Protein, Marmoset, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 30-45 KDa and the accession number is F7I881.
TMPJ-00173	TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-191, His) T-cell membrane protein 3,T-cell immunoglobulin and...	Mouse	HEK293 Cells
	TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-191, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 30-50 KDa and the accession number is Q8VIM0.
TMPJ-00203	Galectin-9 Protein, Human, Recombinant (GST) Gal-9delta5,Ecalectin,LGALS9,Galectin-9,Gal-9δ5,Gal-9,Tumor ...	Human	E. coli
	Galectin-9 is a cytoplasmic protein that contains two galectin domains. Galectin-9 is an S-type lectin that is over-expressed in Hodgkin's disease tissue. Galectin-9 binds galactosides and has high affinity for the Forssman pentasaccharide. Galectin-9 plays a role in thymocyte-epithelial interactions relevant to the biology of the thymus and Inhibits cell proliferation. Galectin-9 is a ligand for HAVCR2/TIM3 and induces T-helper type 1 lymphocyte (Th1) death. In addition, Galectin-9 suppresses t...

重组蛋白

TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-05227

Species: Human

Expression System: HEK293 Cells

TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01621

Species: Human

Expression System: HEK293 Cells

TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-03424

Species: Mouse

Expression System: HEK293 Cells

TIM-3/KIM-3/HAVCR2 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPJ-00189

Species: Cynomolgus

Expression System: HEK293 Cells

TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-03677

Species: Mouse

Expression System: HEK293 Cells

TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (aa 22-200, His)

Cat.No: TMPK-00190

Species: Human

Expression System: HEK293 Cells

TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00189

Species: Human

Expression System: HEK293 Cells

TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc & Avi), Biotinylated

Cat.No: TMPY-06296

Species: Human

Expression System: HEK293 Cells

TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05428

Species: Human

Expression System: HEK293 Cells

TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-05463

Species: Human

Expression System: HEK293 Cells

TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc & His)

Cat.No: TMPJ-00599

Species: Human

Expression System: HEK293 Cells

TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-193, His)

Cat.No: TMPJ-00174

Species: Mouse

Expression System: HEK293 Cells

TIM-3/KIM-3/HAVCR2 Protein, Marmoset, Recombinant (His)

Cat.No: TMPJ-00624

Species: Marmoset

Expression System: HEK293 Cells

TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-191, His)

Cat.No: TMPJ-00173

Species: Mouse

Expression System: HEK293 Cells

Galectin-9 Protein, Human, Recombinant (GST)

Cat.No: TMPJ-00203

Species: Human

Expression System: E. coli

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