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Cat. No. Product Name Target Signaling Pathways
T1788 Tazemetostat

E-7438,EPZ6438

Histone Methyltransferase Chromatin/Epigenetic
Tazemetostat (EPZ6438) 是一种组蛋白甲基转移酶 EZH2 抑制剂 (IC50=11 nM),具有口服活性、选择性和 SAM 竞争性。Tazemetostat 具有抗肿瘤活性,可以用于治疗上皮样肉瘤/滤泡性淋巴瘤。
T17002 Tazemetostat hydrobromide

E-7438 hydrobromide,氢溴酸泰泽司他,EPZ-6438 hydrobromide

Histone Methyltransferase Chromatin/Epigenetic
Tazemetostat hydrobromide (E-7438 hydrobromide) 是口服的EZH2选择性抑制剂。它抑制含有 PRC2 复合体的野生型 EZH2 的活性,Ki 为 2.5 nM。它还抑制 EZH1,IC50为 392 nM。
T70588 Tazemetostat HCl

Tazemetostat HCl is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. EPZ-6438 induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells. Treatment of xenograft-bearing mice with EPZ-6438 leads to dose-dependent regression of MRTs with correlative diminution of intratumoral trimethylation levels of lysine 27 on histone H3, and prevention of tumor regrowth after dosing cessation. These data demonstrate the dependency of SMARCB1...
T15240 Tazemetostat trihydrochloride

EPZ-6438 trihydrochloride,E-7438 trihydrochloride

Histone Methyltransferase Chromatin/Epigenetic
Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2). It inhibits the activity of human PRC2-containing wild-type EZH2 (Ki: 2.5 nM). It inhibits EZH2 (IC50s: 11 and 16 nM in peptide assay and nucleo
T77940 Tazemetostat de(methyl morpholine)-COOH

Ligands for Target Protein for PROTAC PROTAC
Tazemetostat de(methyl morpholine)-COOH(化合物7)是针对EZH2的PROTAC靶向配体,适用于合成EZH2降解剂(PROTACs)。这些降解剂在治疗弥漫性大B细胞淋巴瘤(DLBCL)及其他淋巴瘤亚型中显示出显著的细胞毒性作用。
T74554 Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH

Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH(Compound 21b)为EZH2降解剂,适用于淋巴瘤研究。
T70586 S 2720

S 2720 is a human immunodeficiency virus type 1 (HIV-1)-specific reverse transcriptase (RT) inhibitor quinoxaline.

化合物

Tazemetostat
Cat.No: T1788
Synonym: E-7438,EPZ6438
Target: Histone Methyltransferase
Tazemetostat hydrobromide
Cat.No: T17002
Synonym: E-7438 hydrobromide,氢溴酸泰泽司他,EPZ-6438 hydrobromide
Target: Histone Methyltransferase
Tazemetostat HCl
Cat.No: T70588
Synonym:
Target:
Tazemetostat trihydrochloride
Cat.No: T15240
Synonym: EPZ-6438 trihydrochloride,E-7438 trihydrochloride
Target: Histone Methyltransferase
Tazemetostat de(methyl morpholine)-COOH
Cat.No: T77940
Synonym:
Target: Ligands for Target Protein for PROTAC
Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH
Cat.No: T74554
Synonym:
Target:
S 2720
Cat.No: T70586
Synonym:
Target:
TargetMol Loading
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