Cat. No. | Product Name | Target | Signaling Pathways |
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T38861 |
Tat-beclin 1
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Tat-beclin 1, a peptide derived from the autophagy protein beclin 1, is a powerful inducer of autophagy. It interacts with GAPR-1 (GLIPR2), a negative regulator of autophagy. Tat-beclin 1 effectively reduces the buildup of polyglutamine expansion protein aggregates and inhibits the replication of various pathogens, such as HIV-1, in laboratory experiments. In addition, it has demonstrated the ability to decrease mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV). | |||
T38861L |
Tat-beclin 1 acetate
Tat-beclin 1 acetate(1423821-88-8 free base) |
HIV Protease; Autophagy | Autophagy; Microbiology/Virology; Proteases/Proteasome |
Tat-beclin 1 acetate 是一种有效的自噬诱导剂,并与自噬的负调节因子 GAPR-1 相互作用。 Tat-beclin 1 acetate 减少聚谷氨酰胺扩增蛋白聚集体的积累和几种病原体(包括 HIV-1)的复制。 | |||
T76058 |
Tat-beclin 1 TFA
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Tat-beclin 1 TFA是一种来源于自噬蛋白区域(beclin 1)的肽,有效诱导自噬(autophagy)并与GAPR-1 (GLIPR2)发生相互作用,具有显著的自噬负调控作用。该化合物能有效减少体外聚谷氨酰胺扩增蛋白聚集体的积累,并抑制HIV-1等多种病原体的复制。同时,Tat-beclin 1 TFA能显著降低感染基孔肯雅病(CHIKV)或西尼罗河病毒(WNV)小鼠的死亡率。 |