Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7336 |
ICA-121431
2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl |
Sodium Channel | Membrane transporter/Ion channel |
ICA-121431 (2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl) 是强效的、广谱的电压门控钠通道阻滞剂,对人 Nav1.1 和 Nav1.3 亚型具有等效选择性,IC50分别为 13 nM 和 23 nM。它对Nav1.2 的抑制作用较弱,IC50为240 nM,对 Nav1.4、Nav1.6、抗TTX 的人 Nav1.5、Nav1.8 通道表现出大于 1000 倍的选择性,IC50>10 μM。 | |||
T27205 |
DPI 201-106
DPI-201-106 |
Sodium Channel | Membrane transporter/Ion channel |
DPI 201-106对电压门控钠通道的有心脏选择性调节活性,从而产生正性肌力作用。DPI 201-106 具有协同肌膜和细胞内作用机制。 | |||
T80428 |
Jingzhaotoxin-34
|
Sodium Channel | Membrane transporter/Ion channel |
Jingzhaotoxin-34是一种含35个氨基酸残基的多肽神经毒素,能特异性抑制TTX-S钠电流(IC50约85 nM),对大鼠背根神经节TTX-R钠电流无显著作用。 | |||
T28227 |
Oe-9000
Oe 9000 |
||
Oe-9000 is a blocker of voltage-gated Na(+) currents in neurons. It reversibly reduces rapidly activating and inactivating TTX-sensitive (TTX-S) Na(+) currents as well as slowly activating and inactivating tetrodotoxin-resistant (TTX-R) Na(+) currents at | |||
T80427 |
Jingzhaotoxin-II
|
Sodium Channel | Membrane transporter/Ion channel |
Jingzhaotoxin-II是由32个氨基酸组成的神经毒素,包括两个酸性残基和两个碱性残基。该毒素能够抑制电压门控钠通道(VGSC),并在心肌细胞上明显减缓TTX抗性(TTX-R) VGSC的快速失活,其IC50值为0.26μM。 | |||
T80488 |
µ-Conotoxin SIIIA
|
Sodium Channel | Membrane transporter/Ion channel |
μ-Conotoxin SIIIA为TTX抗性sodium channel拮抗剂,属于毒性肽类,源自Conus snails毒液。该化合物主要应用于神经系统疾病,尤指神经性疼痛的研究。 |